上面的例子使计算差异的问题变得微不足道。假设排序或重复数据删除确实使计算差异变得更容易，但如果您的比较无法承担这些假设，那么您将需要一个diff算法的重要实现。请参阅python标准库中的difflib。

#! /usr/bin/python2
from difflib import SequenceMatcher

A = [1,2,3,4]
B = [2,5]

squeeze=SequenceMatcher( None, A, B )

print "A - B = [%s]"%( reduce( lambda p,q: p+q,
                               map( lambda t: squeeze.a[t[1]:t[2]],
                                    filter(lambda x:x[0]!='equal',
                                           squeeze.get_opcodes() ) ) ) )

或Python3…

#! /usr/bin/python3
from difflib import SequenceMatcher
from functools import reduce

A = [1,2,3,4]
B = [2,5]

squeeze=SequenceMatcher( None, A, B )

print( "A - B = [%s]"%( reduce( lambda p,q: p+q,
                               map( lambda t: squeeze.a[t[1]:t[2]],
                                    filter(lambda x:x[0]!='equal',
                                           squeeze.get_opcodes() ) ) ) ) )

输出:

A - B = [[1, 3, 4]]

您可能希望使用集合而不是列表。

Python 2.7.3(默认，2014年2月27日，19:58:35)- IPython 1.1.0 - timeit:(github gist)

def diff(a, b):
  b = set(b)
  return [aa for aa in a if aa not in b]

def set_diff(a, b):
  return list(set(a) - set(b))

diff_lamb_hension = lambda l1,l2: [x for x in l1 if x not in l2]

diff_lamb_filter = lambda l1,l2: filter(lambda x: x not in l2, l1)

from difflib import SequenceMatcher
def squeezer(a, b):
  squeeze = SequenceMatcher(None, a, b)
  return reduce(lambda p,q: p+q, map(
    lambda t: squeeze.a[t[1]:t[2]],
      filter(lambda x:x[0]!='equal',
        squeeze.get_opcodes())))

结果:

# Small
a = range(10)
b = range(10/2)

timeit[diff(a, b)]
100000 loops, best of 3: 1.97 µs per loop

timeit[set_diff(a, b)]
100000 loops, best of 3: 2.71 µs per loop

timeit[diff_lamb_hension(a, b)]
100000 loops, best of 3: 2.1 µs per loop

timeit[diff_lamb_filter(a, b)]
100000 loops, best of 3: 3.58 µs per loop

timeit[squeezer(a, b)]
10000 loops, best of 3: 36 µs per loop

# Medium
a = range(10**4)
b = range(10**4/2)

timeit[diff(a, b)]
1000 loops, best of 3: 1.17 ms per loop

timeit[set_diff(a, b)]
1000 loops, best of 3: 1.27 ms per loop

timeit[diff_lamb_hension(a, b)]
1 loops, best of 3: 736 ms per loop

timeit[diff_lamb_filter(a, b)]
1 loops, best of 3: 732 ms per loop

timeit[squeezer(a, b)]
100 loops, best of 3: 12.8 ms per loop

# Big
a = xrange(10**7)
b = xrange(10**7/2)

timeit[diff(a, b)]
1 loops, best of 3: 1.74 s per loop

timeit[set_diff(a, b)]
1 loops, best of 3: 2.57 s per loop

timeit[diff_lamb_filter(a, b)]
# too long to wait for

timeit[diff_lamb_filter(a, b)]
# too long to wait for

timeit[diff_lamb_filter(a, b)]
# TypeError: sequence index must be integer, not 'slice'

@roman-bodnarchuk列表推导函数def diff(a, b)似乎更快。

添加一个答案来处理我们想要严格区别重复的情况，也就是说，在第一个列表中有我们想要保留在结果中的重复。例如，得到，

[1, 1, 1, 2] - [1, 1] --> [1, 2]

我们可以用一个额外的计数器来得到一个优雅的差分函数。

from collections import Counter

def diff(first, second):
    secondCntr = Counter(second)
    second = set(second)
    res = []
    for i in first:
        if i not in second:
            res.append(i)
        elif i in secondCntr:
            if secondCntr[i] > 0:
                secondCntr[i] -= 1
            else:
                res.append(i)        
    return res

如果顺序无关紧要，你可以简单地计算集合差值:

>>> set([1,2,3,4]) - set([2,5])
set([1, 4, 3])
>>> set([2,5]) - set([1,2,3,4])
set([5])

你可以做一个

list(set(A)-set(B))

and

list(set(B)-set(A))