在Python 3.3中，添加了新的方法timestamp:

import datetime
seconds_since_epoch = datetime.datetime.now().timestamp()

你的问题说你需要毫秒，你可以得到这样的毫秒:

milliseconds_since_epoch = datetime.datetime.now().timestamp() * 1000

如果在naive datetime对象上使用时间戳，则假定该对象位于本地时区。如果您不希望发生这种情况，请使用时区感知的datetime对象。

这是另一种形式的解决方案与规范化的时间对象:

def to_unix_time(timestamp):
    epoch = datetime.datetime.utcfromtimestamp(0) # start of epoch time
    my_time = datetime.datetime.strptime(timestamp, "%Y/%m/%d %H:%M:%S.%f") # plugin your time object
    delta = my_time - epoch
    return delta.total_seconds() * 1000.0

你可以用德罗宁去时空旅行!

import datetime
import delorean
dt = datetime.datetime.utcnow()
delorean.Delorean(dt, timezone="UTC").epoch

http://delorean.readthedocs.org/en/latest/quickstart.html  

这是将datetime转换为unixtimestampmillis的另一个解决方案。

private static readonly DateTime UnixEpoch = new DateTime(1970, 1, 1, 0, 0, 0, DateTimeKind.Utc);

    public static long GetCurrentUnixTimestampMillis()
    {
        DateTime localDateTime, univDateTime;
        localDateTime = DateTime.Now;          
        univDateTime = localDateTime.ToUniversalTime();
        return (long)(univDateTime - UnixEpoch).TotalMilliseconds;
    } 

在我看来，最简单的方法是

import datetime

epoch = datetime.datetime.utcfromtimestamp(0)

def unix_time_millis(dt):
    return (dt - epoch).total_seconds() * 1000.0

>>> import datetime
>>> # replace datetime.datetime.now() with your datetime object
>>> int(datetime.datetime.now().strftime("%s")) * 1000 
1312908481000

或者时间模块的帮助(没有日期格式):

>>> import datetime, time
>>> # replace datetime.datetime.now() with your datetime object
>>> time.mktime(datetime.datetime.now().timetuple()) * 1000
1312908681000.0

得到了来自:http://pleac.sourceforge.net/pleac_python/datesandtimes.html的帮助

文档:

time.mktime datetime.timetuple