很多答案在python2中不起作用，或者没有从datetime中保存毫秒。这对我很有用

def datetime_to_ms_epoch(dt):
    microseconds = time.mktime(dt.timetuple()) * 1000000 + dt.microsecond
    return int(round(microseconds / float(1000)))

这是另一种形式的解决方案与规范化的时间对象:

def to_unix_time(timestamp):
    epoch = datetime.datetime.utcfromtimestamp(0) # start of epoch time
    my_time = datetime.datetime.strptime(timestamp, "%Y/%m/%d %H:%M:%S.%f") # plugin your time object
    delta = my_time - epoch
    return delta.total_seconds() * 1000.0

from datetime import datetime
from calendar import timegm

# Note: if you pass in a naive dttm object it's assumed to already be in UTC
def unix_time(dttm=None):
    if dttm is None:
       dttm = datetime.utcnow()

    return timegm(dttm.utctimetuple())

print "Unix time now: %d" % unix_time()
print "Unix timestamp from an existing dttm: %d" % unix_time(datetime(2014, 12, 30, 12, 0))

一段熊猫代码:

import pandas

def to_millis(dt):
    return int(pandas.to_datetime(dt).value / 1000000)

在我看来，最简单的方法是

import datetime

epoch = datetime.datetime.utcfromtimestamp(0)

def unix_time_millis(dt):
    return (dt - epoch).total_seconds() * 1000.0

import time
seconds_since_epoch = time.mktime(your_datetime.timetuple()) * 1000