我是这样做的:

from datetime import datetime
from time import mktime

dt = datetime.now()
sec_since_epoch = mktime(dt.timetuple()) + dt.microsecond/1000000.0

millis_since_epoch = sec_since_epoch * 1000

>>> import datetime
>>> # replace datetime.datetime.now() with your datetime object
>>> int(datetime.datetime.now().strftime("%s")) * 1000 
1312908481000

或者时间模块的帮助(没有日期格式):

>>> import datetime, time
>>> # replace datetime.datetime.now() with your datetime object
>>> time.mktime(datetime.datetime.now().timetuple()) * 1000
1312908681000.0

得到了来自:http://pleac.sourceforge.net/pleac_python/datesandtimes.html的帮助

文档:

time.mktime datetime.timetuple

我是这样做的:

from datetime import datetime
from time import mktime

dt = datetime.now()
sec_since_epoch = mktime(dt.timetuple()) + dt.microsecond/1000000.0

millis_since_epoch = sec_since_epoch * 1000

from datetime import datetime
from calendar import timegm

# Note: if you pass in a naive dttm object it's assumed to already be in UTC
def unix_time(dttm=None):
    if dttm is None:
       dttm = datetime.utcnow()

    return timegm(dttm.utctimetuple())

print "Unix time now: %d" % unix_time()
print "Unix timestamp from an existing dttm: %d" % unix_time(datetime(2014, 12, 30, 12, 0))

很多答案在python2中不起作用，或者没有从datetime中保存毫秒。这对我很有用

def datetime_to_ms_epoch(dt):
    microseconds = time.mktime(dt.timetuple()) * 1000000 + dt.microsecond
    return int(round(microseconds / float(1000)))

你可以用德罗宁去时空旅行!

import datetime
import delorean
dt = datetime.datetime.utcnow()
delorean.Delorean(dt, timezone="UTC").epoch

http://delorean.readthedocs.org/en/latest/quickstart.html