我是这样做的:

from datetime import datetime
from time import mktime

dt = datetime.now()
sec_since_epoch = mktime(dt.timetuple()) + dt.microsecond/1000000.0

millis_since_epoch = sec_since_epoch * 1000

import time
seconds_since_epoch = time.mktime(your_datetime.timetuple()) * 1000

很多答案在python2中不起作用，或者没有从datetime中保存毫秒。这对我很有用

def datetime_to_ms_epoch(dt):
    microseconds = time.mktime(dt.timetuple()) * 1000000 + dt.microsecond
    return int(round(microseconds / float(1000)))

我是这样做的:

from datetime import datetime
from time import mktime

dt = datetime.now()
sec_since_epoch = mktime(dt.timetuple()) + dt.microsecond/1000000.0

millis_since_epoch = sec_since_epoch * 1000

这是另一种形式的解决方案与规范化的时间对象:

def to_unix_time(timestamp):
    epoch = datetime.datetime.utcfromtimestamp(0) # start of epoch time
    my_time = datetime.datetime.strptime(timestamp, "%Y/%m/%d %H:%M:%S.%f") # plugin your time object
    delta = my_time - epoch
    return delta.total_seconds() * 1000.0

Python 2.7文档对time模块的建议