我认为第一种方法(多个变量)是最好的，否则你就会得到这样的结果(来自使用KnockoutJS的应用程序)，这在我看来很难理解:

    var categories = ko.observableArray(),
        keywordFilter = ko.observableArray(),
        omniFilter = ko.observable('').extend({ throttle: 300 }),
        filteredCategories = ko.computed(function () {
            var underlyingArray = categories();
            return ko.utils.arrayFilter(underlyingArray, function (n) {
                return n.FilteredSportCount() > 0;
            });
        }),
        favoriteSports = ko.computed(function () {
            var sports = ko.observableArray();
            ko.utils.arrayForEach(categories(), function (c) {
                ko.utils.arrayForEach(c.Sports(), function (a) {
                    if (a.IsFavorite()) {
                        sports.push(a);
                    }
                });
            });
            return sports;
        }),
        toggleFavorite = function (sport, userId) {
            var isFavorite = sport.IsFavorite();

            var url = setfavouritesurl;

            var data = {
                userId: userId,
                sportId: sport.Id(),
                isFavourite: !isFavorite
            };

            var callback = function () {
                sport.IsFavorite(!isFavorite);
            };

            jQuery.support.cors = true;
            jQuery.ajax({
                url: url,
                type: "GET",
                data: data,
                success: callback
            });
        },
        hasfavoriteSports = ko.computed(function () {
            var result = false;
            ko.utils.arrayForEach(categories(), function (c) {
                ko.utils.arrayForEach(c.Sports(), function (a) {
                    if (a.IsFavorite()) {
                        result = true;
                    }
                });
            });
            return result;
        });

这样做的时候可读性更强:

var hey = 23;
var hi = 3;
var howdy 4;

但是这种方法占用的空间和代码行数更少:

var hey=23,hi=3,howdy=4;

它是节省空间的理想选择，但是让JavaScript压缩器为您处理它。

除了可维护性，第一种方法消除了意外创建全局变量的可能性:

(function () {
var variable1 = "Hello, World!" // Semicolon is missed out accidentally
var variable2 = "Testing..."; // Still a local variable
var variable3 = 42;
}());

而第二种方式就不那么宽容了:

(function () {
var variable1 = "Hello, World!" // Comma is missed out accidentally
    variable2 = "Testing...", // Becomes a global variable
    variable3 = 42; // A global variable as well
}());

ECMAScript 2015引入了解构赋值，效果非常好:

[a, b] = [1, 2]

A等于1 b等于2。

我唯一的，也是最重要的，逗号的用法是在for循环中:

for (var i = 0, n = a.length; i < n; i++) {
  var e = a[i];
  console.log(e);
}

我在JavaScript中查看了一下这个是否可以。

即使它是可行的，一个问题仍然是n是否对函数是局部的。

这验证了n是本地的:

a = [3, 5, 7, 11];
(function l () { for (var i = 0, n = a.length; i < n; i++) {
  var e = a[i];
  console.log(e);
}}) ();
console.log(typeof n == "undefined" ?
  "as expected, n was local" : "oops, n was global");

在语言之间切换，我一时拿不准。

我相信在我们开始使用ES6之前，使用单一的var声明的方法既不好也不好(如果你有lints和'use strict'的话)。这真的是一种口味偏好。但现在我的情况变了。以下是我对多行声明的一些看法:

Now we have two new kinds of variables, and var became obsolete. It is good practice to use const everywhere until you really need let. So quite often your code will contain variable declarations with assignment in the middle of the code, and because of block scoping you quite often will move variables between blocks in case of small changes. I think that it is more convenient to do that with multiline declarations. ES6 syntax became more diverse, we got destructors, template strings, arrow functions and optional assignments. When you heavily use all those features with single variable declarations, it hurts readability.