nice @liangli的解决方案略有变化，不需要改变现有数据框架的索引:

newdf = df1.drop(df1.join(df2.set_index('Name').index))

通过索引查找差异。假设df1是df2的一个子集，并且在进行子集设置时将索引前移

df1.loc[set(df1.index).symmetric_difference(set(df2.index))].dropna()

# Example

df1 = pd.DataFrame({"gender":np.random.choice(['m','f'],size=5), "subject":np.random.choice(["bio","phy","chem"],size=5)}, index = [1,2,3,4,5])

df2 =  df1.loc[[1,3,5]]

df1

 gender subject
1      f     bio
2      m    chem
3      f     phy
4      m     bio
5      f     bio

df2

  gender subject
1      f     bio
3      f     phy
5      f     bio

df3 = df1.loc[set(df1.index).symmetric_difference(set(df2.index))].dropna()

df3

  gender subject
2      m    chem
4      m     bio

import pandas as pd
# given
df1 = pd.DataFrame({'Name':['John','Mike','Smith','Wale','Marry','Tom','Menda','Bolt','Yuswa',],
    'Age':[23,45,12,34,27,44,28,39,40]})
df2 = pd.DataFrame({'Name':['John','Smith','Wale','Tom','Menda','Yuswa',],
    'Age':[23,12,34,44,28,40]})

# find elements in df1 that are not in df2
df_1notin2 = df1[~(df1['Name'].isin(df2['Name']) & df1['Age'].isin(df2['Age']))].reset_index(drop=True)

# output:
print('df1\n', df1)
print('df2\n', df2)
print('df_1notin2\n', df_1notin2)

# df1
#     Age   Name
# 0   23   John
# 1   45   Mike
# 2   12  Smith
# 3   34   Wale
# 4   27  Marry
# 5   44    Tom
# 6   28  Menda
# 7   39   Bolt
# 8   40  Yuswa
# df2
#     Age   Name
# 0   23   John
# 1   12  Smith
# 2   34   Wale
# 3   44    Tom
# 4   28  Menda
# 5   40  Yuswa
# df_1notin2
#     Age   Name
# 0   45   Mike
# 1   27  Marry
# 2   39   Bolt

另一个可能的解决方案是使用numpy广播:

df1[np.all(~np.all(df1.values == df2.values[:, None], axis=2), axis=0)]

输出:

    Name  Age
1   Mike   45
4  Marry   27
7   Bolt   39

我发现deepdiff库是一个很棒的工具，如果需要不同的细节或排序问题，它也可以很好地扩展到数据框架。你可以尝试不同的to_dict('records')， to_numpy()和其他导出:

import pandas as pd
from deepdiff import DeepDiff

df1 = pd.DataFrame({
    'Name':
        ['John','Mike','Smith','Wale','Marry','Tom','Menda','Bolt','Yuswa'],
    'Age':
        [23,45,12,34,27,44,28,39,40]
})

df2 = df1[df1.Name.isin(['John','Smith','Wale','Tom','Menda','Yuswa'])]

DeepDiff(df1.to_dict(), df2.to_dict())
# {'dictionary_item_removed': [root['Name'][1], root['Name'][4], root['Name'][7], root['Age'][1], root['Age'][4], root['Age'][7]]}

使用lambda函数，您可以过滤_merge值为“left_only”的行，以获得df1中df2中缺失的所有行

df3 = df1.merge(df2, how = 'outer' ,indicator=True).loc[lambda x :x['_merge']=='left_only']
df