尝试将文件移动/复制到临时目录。如果可以的话，它没有锁，您可以安全地在临时目录中工作而不需要锁。否则就在x秒内再移动一次。

尝试将文件移动/复制到临时目录。如果可以的话，它没有锁，您可以安全地在临时目录中工作而不需要锁。否则就在x秒内再移动一次。

static bool FileInUse(string path)
    {
        try
        {
            using (FileStream fs = new FileStream(path, FileMode.OpenOrCreate))
            {
                fs.CanWrite
            }
            return false;
        }
        catch (IOException ex)
        {
            return true;
        }
    }

string filePath = "C:\\Documents And Settings\\yourfilename";
bool isFileInUse;

isFileInUse = FileInUse(filePath);

// Then you can do some checking
if (isFileInUse)
   Console.WriteLine("File is in use");
else
   Console.WriteLine("File is not in use");

希望这能有所帮助!

I once needed to upload PDFs to an online backup archive. But the backup would fail if the user had the file open in another program (such as PDF reader). In my haste, I attempted a few of the top answers in this thread but could not get them to work. What did work for me was trying to move the PDF file to its own directory. I found that this would fail if the file was open in another program, and if the move were successful there would be no restore-operation required as there would be if it were moved to a separate directory. I want to post my basic solution in case it may be useful for others' specific use cases.

string str_path_and_name = str_path + '\\' + str_filename;
FileInfo fInfo = new FileInfo(str_path_and_name);
bool open_elsewhere = false;
try
{
    fInfo.MoveTo(str_path_and_name);
}
catch (Exception ex)
{
    open_elsewhere = true;
}

if (open_elsewhere)
{
    //handle case
}

上面接受的答案遇到了一个问题，如果文件已被打开以使用FileShare写入。读取模式或如果文件具有只读属性，代码将无法工作。这个修改后的解决方案最可靠，需要记住两件事(对于公认的解决方案也是如此):

它将不适用于已以写共享模式打开的文件 这没有考虑到线程问题，所以你需要锁定它或单独处理线程问题。

记住上面的内容，这将检查文件是被写入锁定还是被阻止读取锁定:

public static bool FileLocked(string FileName)
{
    FileStream fs = null;

    try
    {
        // NOTE: This doesn't handle situations where file is opened for writing by another process but put into write shared mode, it will not throw an exception and won't show it as write locked
        fs = File.Open(FileName, FileMode.Open, FileAccess.ReadWrite, FileShare.None); // If we can't open file for reading and writing then it's locked by another process for writing
    }
    catch (UnauthorizedAccessException) // https://msdn.microsoft.com/en-us/library/y973b725(v=vs.110).aspx
    {
        // This is because the file is Read-Only and we tried to open in ReadWrite mode, now try to open in Read only mode
        try
        {
            fs = File.Open(FileName, FileMode.Open, FileAccess.Read, FileShare.None);
        }
        catch (Exception)
        {
            return true; // This file has been locked, we can't even open it to read
        }
    }
    catch (Exception)
    {
        return true; // This file has been locked
    }
    finally
    {
        if (fs != null)
            fs.Close();
    }
    return false;
}

retry_possibility:
//somecode here

try
{
    using(FileStream stream = file.Open(FileMode.Open, FileAccess.Read, FileShare.None))
    {
        stream.Close();
    }
    //write or open your file here
}
catch (IOException)
{
    DialogResult dialogResult = MessageBox.Show("This file is opened by you or another user. Please close it and press retry.\n"+ expFilePath, "File Locked", MessageBoxButtons.RetryCancel);
    if (dialogResult == DialogResult.Retry)
    {
        goto retry_possibility;
    }
    else if (dialogResult == DialogResult.Cancel)
    {
        //do nothing
    }
}