只要看看“C:\Program Files (x86)”是否存在。如果不是，那么你使用的是32位操作系统。如果是这样，那么操作系统是64位(Windows Vista或Windows 7)。

最快的方式:

if(IntPtr.Size == 8) {
    // 64 bit machine
} else if(IntPtr.Size == 4)  {
    // 32 bit machine
} 

注意:这是非常直接的，只有当程序不强制作为32位进程执行时(例如，在项目设置中通过<Prefer32Bit>true</Prefer32Bit>)，才能在64位上正确工作。

. net 4在环境类中有两个新属性，Is64BitProcess和Is64BitOperatingSystem。有趣的是，如果你使用Reflector，你会发现它们在32位和64位版本的mscorlib中实现的不同。32位版本为Is64BitProcess返回false，并通过P/Invoke为Is64BitOperatingSystem调用IsWow64Process。64位版本对两者都返回true。

这是一个基于微软http://1code.codeplex.com/SourceControl/changeset/view/39074#842775代码的解决方案。它使用扩展方法方便代码重用。

下面是一些可能的用法:

bool bIs64BitOS = System.Environment.OSVersion.IsWin64BitOS();

bool bIs64BitProc = System.Diagnostics.Process.GetCurrentProcess().Is64BitProc();

//Hosts the extension methods  
public static class OSHelperTools  
{  
    /// <summary>     
    /// The function determines whether the current operating system is a      
    /// 64-bit operating system.     
    /// </summary>     
    /// <returns>     
    /// The function returns true if the operating system is 64-bit;      
    /// otherwise, it returns false.     
    /// </returns>    
    public static bool IsWin64BitOS(this OperatingSystem os)  
    {  
        if (IntPtr.Size == 8)  
        // 64-bit programs run only on Win64           
            return true;   
        else// 32-bit programs run on both 32-bit and 64-bit Windows     
        {   // Detect whether the current process is a 32-bit process                
            // running on a 64-bit system.               
            return Process.GetCurrentProcess().Is64BitProc();  
        }  
    }  

    /// <summary>  
    /// Checks if the process is 64 bit  
    /// </summary>  
    /// <param name="os"></param>  
    /// <returns>  
    /// The function returns true if the process is 64-bit;        
    /// otherwise, it returns false.  
    /// </returns>    
    public static bool Is64BitProc(this System.Diagnostics.Process p)  
    {  
        // 32-bit programs run on both 32-bit and 64-bit Windows           
        // Detect whether the current process is a 32-bit process                
        // running on a 64-bit system.               
        bool result;  
        return ((DoesWin32MethodExist("kernel32.dll", "IsWow64Process") && IsWow64Process(p.Handle, out result)) && result);  
    }  

    /// <summary>     
    /// The function determins whether a method exists in the export      
    /// table of a certain module.     
    /// </summary>     
    /// <param name="moduleName">The name of the module</param>     
    /// <param name="methodName">The name of the method</param>     
    /// <returns>     
    /// The function returns true if the method specified by methodName      
    /// exists in the export table of the module specified by moduleName.     
    /// </returns>       
    static bool DoesWin32MethodExist(string moduleName, string methodName)  
    {  
        IntPtr moduleHandle = GetModuleHandle(moduleName);  
        if (moduleHandle == IntPtr.Zero)  
            return false;    
        return (GetProcAddress(moduleHandle, methodName) != IntPtr.Zero);   
    }  
    [DllImport("kernel32.dll")]  
    static extern IntPtr GetCurrentProcess();  

    [DllImport("kernel32.dll", CharSet = CharSet.Auto)]  
    static extern IntPtr GetModuleHandle(string moduleName);  

    [DllImport("kernel32", CharSet = CharSet.Auto, SetLastError = true)]  
    static extern IntPtr GetProcAddress(IntPtr hModule, [MarshalAs(UnmanagedType.LPStr)]string procName);  

    [DllImport("kernel32.dll", CharSet = CharSet.Auto, SetLastError = true)]  
    [return: MarshalAs(UnmanagedType.Bool)]  
    static extern bool IsWow64Process(IntPtr hProcess, out bool wow64Process);  
}

我需要这样做，但我也需要能够作为一个管理员远程做到这一点，无论是哪种情况下，这似乎很适合我:

    public static bool is64bit(String host)
    {
        using (var reg = RegistryKey.OpenRemoteBaseKey(RegistryHive.LocalMachine, host))
        using (var key = reg.OpenSubKey(@"Software\Microsoft\Windows\CurrentVersion\"))
        {
            return key.GetValue("ProgramFilesDir (x86)") !=null;
        }
    }

更新:正如Joel Coehoorn和其他人建议的那样，从。net Framework 4.0开始，你可以只检查Environment.Is64BitOperatingSystem。

IntPtr。如果在64位Windows上运行32位的. net Framework 2.0, Size将不会返回正确的值(它将返回32位)。

正如微软的Raymond Chen所描述的，你必须首先检查是否运行在64位进程中(我认为在。net中你可以通过检查IntPtr.Size来做到这一点)，如果你运行在32位进程中，你仍然必须调用Win API函数IsWow64Process。如果返回true，则在64位Windows上运行32位进程。

微软的Raymond Chen: 如何以编程方式检测您是否运行在64位Windows上

我的解决方案:

static bool is64BitProcess = (IntPtr.Size == 8);
static bool is64BitOperatingSystem = is64BitProcess || InternalCheckIsWow64();

[DllImport("kernel32.dll", SetLastError = true, CallingConvention = CallingConvention.Winapi)]
[return: MarshalAs(UnmanagedType.Bool)]
private static extern bool IsWow64Process(
    [In] IntPtr hProcess,
    [Out] out bool wow64Process
);

public static bool InternalCheckIsWow64()
{
    if ((Environment.OSVersion.Version.Major == 5 && Environment.OSVersion.Version.Minor >= 1) ||
        Environment.OSVersion.Version.Major >= 6)
    {
        using (Process p = Process.GetCurrentProcess())
        {
            bool retVal;
            if (!IsWow64Process(p.Handle, out retVal))
            {
                return false;
            }
            return retVal;
        }
    }
    else
    {
        return false;
    }
}