static async Task<AccessToken> GetToken()
{
        string clientId = "XXX";
        string clientSecret = "YYY";
        string credentials = String.Format("{0}:{1}", clientId, clientSecret);

        using (var client = new HttpClient())
        {
            client.DefaultRequestHeaders.Authorization = new AuthenticationHeaderValue("Basic", Convert.ToBase64String(Encoding.UTF8.GetBytes(credentials)));
            List<KeyValuePair<string, string>> requestData = new List<KeyValuePair<string, string>>();
            requestData.Add(new KeyValuePair<string, string>("grant_type", "client_credentials"));
            FormUrlEncodedContent requestBody = new FormUrlEncodedContent(requestData);
            var request = await client.PostAsync("https://accounts.spotify.com/api/token", requestBody);
            var response = await request.Content.ReadAsStringAsync();
            return JsonConvert.DeserializeObject<AccessToken>(response);
        }
    }

request.DefaultRequestHeaders.Authorization = 
    new AuthenticationHeaderValue(
        "Basic", Convert.ToBase64String(
            System.Text.ASCIIEncoding.ASCII.GetBytes(
               $"{yourusername}:{yourpwd}")));

这可能有助于设置标题:

WebClient client = new WebClient();

string authInfo = this.credentials.UserName + ":" + this.credentials.Password;
authInfo = Convert.ToBase64String(Encoding.Default.GetBytes(authInfo));
client.Headers["Authorization"] = "Basic " + authInfo;

6年过去了，但为了帮助别人，我加了这个。

https://www.codeproject.com/Tips/996401/Authenticate-WebAPIs-with-Basic-and-Windows-Authen

var authenticationBytes = Encoding.ASCII.GetBytes("<username>:<password>");
using (HttpClient confClient = new HttpClient())
{
  confClient.DefaultRequestHeaders.Authorization = new AuthenticationHeaderValue("Basic", 
         Convert.ToBase64String(authenticationBytes));
  confClient.DefaultRequestHeaders.Accept.Add(new MediaTypeWithQualityHeaderValue(Constants.MediaType));  
  HttpResponseMessage message = confClient.GetAsync("<service URI>").Result;
  if (message.IsSuccessStatusCode)
  {
    var inter = message.Content.ReadAsStringAsync();
    List<string> result = JsonConvert.DeserializeObject<List<string>>(inter.Result);
  }
}

使用基本授权和Json参数。

using (HttpClient client = new HttpClient())
{
    var request_json = "your json string";

    var content = new StringContent(request_json, Encoding.UTF8, "application/json");

    var authenticationBytes = Encoding.ASCII.GetBytes("YourUsername:YourPassword");

    client.DefaultRequestHeaders.Authorization = new AuthenticationHeaderValue("Basic",
            Convert.ToBase64String(authenticationBytes));
    client.DefaultRequestHeaders.Accept.Add(new MediaTypeWithQualityHeaderValue("application/json"));

    var result = await client.PostAsync("YourURL", content);

    var result_string = await result.Content.ReadAsStringAsync();
}

如果你想重用HttpClient，建议不要使用DefaultRequestHeaders，因为它们是用来发送每个请求的。

你可以试试这个:

var requestMessage = new HttpRequestMessage
    {
        Method = HttpMethod.Post,
        Content = new StringContent("...", Encoding.UTF8, "application/json"),
        RequestUri = new Uri("...")
    };

requestMessage.Headers.Authorization = new AuthenticationHeaderValue("Basic", 
    Convert.ToBase64String(System.Text.ASCIIEncoding.ASCII.GetBytes($"{user}:{password}")));

var response = await _httpClient.SendAsync(requestMessage);