使用正则表达式。替换，像这样:

  string input = "This is   text with   far  too   much   " + 
                 "whitespace.";
  string pattern = "[;,]";
  string replacement = "\n";
  Regex rgx = new Regex(pattern);
  string result = rgx.Replace(input, replacement);

这里是关于RegEx的MSDN文档的更多信息。取代

这是最短的方法:

myString = Regex.Replace(myString, @"[;,\t\r ]|[\n]{2}", "\n");

就性能而言，这可能不是最好的解决方案，但它确实有效。

var str = "filename:with&bad$separators.txt";
char[] charArray = new char[] { '#', '%', '&', '{', '}', '\\', '<', '>', '*', '?', '/', ' ', '$', '!', '\'', '"', ':', '@' };
foreach (var singleChar in charArray)
{
   str = str.Replace(singleChar, '_');
}

使用正则表达式。替换，像这样:

  string input = "This is   text with   far  too   much   " + 
                 "whitespace.";
  string pattern = "[;,]";
  string replacement = "\n";
  Regex rgx = new Regex(pattern);
  string result = rgx.Replace(input, replacement);

这里是关于RegEx的MSDN文档的更多信息。取代

哦，表演太恐怖了! 答案有点过时了，但仍然……

public static class StringUtils
{
    #region Private members

    [ThreadStatic]
    private static StringBuilder m_ReplaceSB;

    private static StringBuilder GetReplaceSB(int capacity)
    {
        var result = m_ReplaceSB;

        if (null == result)
        {
            result = new StringBuilder(capacity);
            m_ReplaceSB = result;
        }
        else
        {
            result.Clear();
            result.EnsureCapacity(capacity);
        }

        return result;
    }


    public static string ReplaceAny(this string s, char replaceWith, params char[] chars)
    {
        if (null == chars)
            return s;

        if (null == s)
            return null;

        StringBuilder sb = null;

        for (int i = 0, count = s.Length; i < count; i++)
        {
            var temp = s[i];
            var replace = false;

            for (int j = 0, cc = chars.Length; j < cc; j++)
                if (temp == chars[j])
                {
                    if (null == sb)
                    {
                        sb = GetReplaceSB(count);
                        if (i > 0)
                            sb.Append(s, 0, i);
                    }

                    replace = true;
                    break;
                }

            if (replace)
                sb.Append(replaceWith);
            else
                if (null != sb)
                    sb.Append(temp);
        }

        return null == sb ? s : sb.ToString();
    }
}

string ToBeReplaceCharacters = @"~()@#$%&+,'"<>|;\/*?";
string fileName = "filename;with<bad:separators?";

foreach (var RepChar in ToBeReplaceCharacters)
{
    fileName = fileName.Replace(RepChar.ToString(), "");
}