这就是你的问题所在。窗口框右上方的关闭按钮不是WPF窗口的一部分，但它属于由操作系统控制的窗口框的一部分。这意味着你必须使用Win32互操作来实现。

或者，您可以使用noframe并提供您自己的“框架”或根本没有框架。

我非常喜欢这个答案，它使用附加属性来调节行为。然而，我发现答案的实现过于复杂，它也没有解决防止窗口关闭的次要目标，即使使用Alt+F4。所以我提供了另一种选择:

enum CloseButtonVisibility
{
    Visible,
    Hidden,
    CloseDisabled,
}

static class WindowEx
{
    private static readonly CancelEventHandler _cancelCloseHandler = (sender, e) => e.Cancel = true;

    public static readonly DependencyProperty CloseButtonVisibilityProperty =
        DependencyProperty.RegisterAttached(
            "CloseButtonVisibility",
            typeof(CloseButtonVisibility),
            typeof(WindowEx),
            new FrameworkPropertyMetadata(CloseButtonVisibility.Visible, new PropertyChangedCallback(_OnCloseButtonChanged)));

    [AttachedPropertyBrowsableForType(typeof(Window))]
    public static CloseButtonVisibility GetCloseButtonVisibility(Window obj)
    {
        return (CloseButtonVisibility)obj.GetValue(CloseButtonVisibilityProperty);
    }

    [AttachedPropertyBrowsableForType(typeof(Window))]
    public static void SetCloseButtonVisibility(Window obj, CloseButtonVisibility value)
    {
        obj.SetValue(CloseButtonVisibilityProperty, value);
    }

    private static void _OnCloseButtonChanged(DependencyObject d, DependencyPropertyChangedEventArgs e)
    {
        if (!(d is Window window))
        {
            return;
        }

        if (e.OldValue is CloseButtonVisibility oldVisibility)
        {
            if (oldVisibility == CloseButtonVisibility.CloseDisabled)
            {
                window.Closing -= _cancelCloseHandler;
            }
        }

        if (e.NewValue is CloseButtonVisibility newVisibility)
        {
            if (newVisibility == CloseButtonVisibility.CloseDisabled)
            {
                window.Closing += _cancelCloseHandler;
            }

            if (!window.IsLoaded)
            {
                // NOTE: if the property is set multiple times before the window is loaded,
                // the window will wind up with multiple event handlers. But they will all
                // set the same value, so this is fine from a functionality point of view.
                //
                // The handler is never unsubscribed, so there is some nominal overhead there.
                // But it would be incredibly unusual for this to be set more than once
                // before the window is loaded, and even a handful of delegate instances
                // being around that are no longer needed is not really a big deal.
                window.Loaded += _ApplyCloseButtonVisibility;
            }
            else
            {
                _SetVisibility(window, newVisibility);
            }
        }
    }

    #region Win32 imports

    private const int GWL_STYLE = -16;
    private const int WS_SYSMENU = 0x80000;
    [DllImport("user32.dll", SetLastError = true)]
    private static extern int GetWindowLong(IntPtr hWnd, int nIndex);
    [DllImport("user32.dll")]
    private static extern int SetWindowLong(IntPtr hWnd, int nIndex, int dwNewLong);

    #endregion

    private static void _ApplyCloseButtonVisibility(object sender, RoutedEventArgs e)
    {
        Window window = (Window)sender;
        CloseButtonVisibility visibility = GetCloseButtonVisibility(window);

        _SetVisibility(window, visibility);
    }

    private static void _SetVisibility(Window window, CloseButtonVisibility visibility)
    {
        var hwnd = new WindowInteropHelper(window).Handle;

        if (visibility == CloseButtonVisibility.Visible)
        {
            SetWindowLong(hwnd, GWL_STYLE, GetWindowLong(hwnd, GWL_STYLE) | WS_SYSMENU);
        }
        else
        {
            SetWindowLong(hwnd, GWL_STYLE, GetWindowLong(hwnd, GWL_STYLE) & ~WS_SYSMENU);
        }
    }
}

这提供了三种状态可供选择:

可见 隐藏，但用户仍然可以使用Alt+F4关闭 隐藏，关闭是完全禁用的

请注意，默认情况下，永不关闭的窗口将防止WPF程序的进程终止。如果你选择使用CloseButtonVisibility。值CloseDisabled时，您将需要定制Application.Run()行为，或者在退出前重新启用关闭窗口。例如，在你的主窗口中，你可能会有这样的东西:

protected override void OnClosed(EventArgs e)
{
    WindowEx.SetCloseButtonVisibility(this.toolWindow.Value, CloseButtonVisibility.Hidden);
    this.toolWindow.Value.Close();

    base.OnClosed(e);
}

其中toolWindow是关闭按钮被禁用的窗口的窗口引用。

上面假设在正常的UI活动期间，窗口通常只是隐藏并根据需要显示。当然，您也可以选择在任何时候显式地关闭窗口，但是同样的技术—将选项设置为不禁用关闭，然后显式地关闭窗口—仍然适用。

如果需要的只是禁止用户关闭窗口，这是一个简单的解决方案。

XAML守则: IsCloseButtonEnabled =“虚假”

它挡住了按钮。

使用这个，从https://stephenhaunts.com/2014/09/25/remove-the-close-button-from-a-wpf-window修改:

using System;
using System.Runtime.InteropServices;
using System.Windows;
using System.Windows.Input;
using System.Windows.Interop;
using System.Windows.Media;

namespace Whatever
{
    public partial class MainMenu : Window
    {
        private const int GWL_STYLE = -16;
        private const int WS_SYSMENU = 0x00080000;

        [DllImport("user32.dll", SetLastError = true)]
        private static extern int GetWindowLongPtr(IntPtr hWnd, int nIndex);

        [DllImport("user32.dll")]
        private static extern int SetWindowLong(IntPtr hWnd, int nIndex, int dwNewLong);

        public MainMenu()
        {
             InitializeComponent();
             this.Loaded += new RoutedEventHandler(Window_Loaded);
        }

        private void Window_Loaded(object sender, RoutedEventArgs e)
        {
            var hwnd = new WindowInteropHelper(this).Handle;
            SetWindowLongPtr(hwnd, GWL_STYLE, GetWindowLongPtr(hwnd, GWL_STYLE) & ~WS_SYSMENU);
        }  

    }
}

让用户“关闭”窗口，但实际上只是隐藏它。

在窗口的OnClosing事件中，隐藏已经可见的窗口:

    If Me.Visibility = Windows.Visibility.Visible Then
        Me.Visibility = Windows.Visibility.Hidden
        e.Cancel = True
    End If

每次后台线程执行时，重新显示后台UI窗口:

    w.Visibility = Windows.Visibility.Visible
    w.Show()

当终止程序执行时，确保所有窗口都是/可以关闭的:

Private Sub CloseAll()
    If w IsNot Nothing Then
        w.Visibility = Windows.Visibility.Collapsed ' Tell OnClosing to really close
        w.Close()
    End If
End Sub

这不会消除关闭按钮，但它将阻止某人关闭窗口。

把这个放在文件后面的代码中:

protected override void OnClosing(CancelEventArgs e)
{
   base.OnClosing(e);
   e.Cancel = true;
}