我已经能够做到这一点的方式如下:

Mapper.CreateMap<SourceType, DestinationType>().ForAllMembers(opt => opt.Ignore());
Mapper.CreateMap<SourceType, DestinationType>().ForMember(/*Do explicit mapping 1 here*/);
Mapper.CreateMap<SourceType, DestinationType>().ForMember(/*Do explicit mapping 2 here*/);
...

注意:我使用的是AutoMapper v.2.0。

从AutoMapper 5.0开始，IMappingExpression上的. typemap属性消失了，这意味着4.2解决方案不再有效。我已经创建了一个解决方案，使用原始功能，但具有不同的语法:

var config = new MapperConfiguration(cfg =>
{
    cfg.CreateMap<Src, Dest>();
    cfg.IgnoreUnmapped();        // Ignores unmapped properties on all maps
    cfg.IgnoreUnmapped<Src, Dest>();  // Ignores unmapped properties on specific map
});

// or add  inside a profile
public class MyProfile : Profile
{
   this.IgnoreUnmapped();
   CreateMap<MyType1, MyType2>();
}

实现:

public static class MapperExtensions
{
    private static void IgnoreUnmappedProperties(TypeMap map, IMappingExpression expr)
    {
        foreach (string propName in map.GetUnmappedPropertyNames())
        {
            if (map.SourceType.GetProperty(propName) != null)
            {
                expr.ForSourceMember(propName, opt => opt.Ignore());
            }
            if (map.DestinationType.GetProperty(propName) != null)
            {
                expr.ForMember(propName, opt => opt.Ignore());
            }
        }
    }

    public static void IgnoreUnmapped(this IProfileExpression profile)
    {
        profile.ForAllMaps(IgnoreUnmappedProperties);
    }

    public static void IgnoreUnmapped(this IProfileExpression profile, Func<TypeMap, bool> filter)
    {
        profile.ForAllMaps((map, expr) =>
        {
            if (filter(map))
            {
                IgnoreUnmappedProperties(map, expr);
            }
        });
    }

    public static void IgnoreUnmapped(this IProfileExpression profile, Type src, Type dest)
    {
        profile.IgnoreUnmapped((TypeMap map) => map.SourceType == src && map.DestinationType == dest);
    }

    public static void IgnoreUnmapped<TSrc, TDest>(this IProfileExpression profile)
    {
        profile.IgnoreUnmapped(typeof(TSrc), typeof(TDest));
    }
}

这个问题已经问了几年了，但是这个扩展方法对我来说似乎更干净，使用当前版本的AutoMapper (3.2.1):

public static IMappingExpression<TSource, TDestination> IgnoreUnmappedProperties<TSource, TDestination>(this IMappingExpression<TSource, TDestination> expression)
{
    var typeMap = Mapper.FindTypeMapFor<TSource, TDestination>();
    if (typeMap != null)
    {
        foreach (var unmappedPropertyName in typeMap.GetUnmappedPropertyNames())
        {
            expression.ForMember(unmappedPropertyName, opt => opt.Ignore());
        }
    }

    return expression;
}

当前(版本9)忽略目标类型中不存在的属性的解决方案是创建一个翻转映射并反转它:

var config = new MapperConfiguration(cfg => {
  cfg.CreateMap<TheActualDestinationType, TheActualSourceType>().ReverseMap();
});

我已经更新了Can Gencer的扩展，不覆盖任何现有的地图。

public static IMappingExpression<TSource, TDestination> 
    IgnoreAllNonExisting<TSource, TDestination>(this IMappingExpression<TSource, TDestination> expression)
{
    var sourceType = typeof (TSource);
    var destinationType = typeof (TDestination);
    var existingMaps = Mapper.GetAllTypeMaps().First(x => x.SourceType.Equals(sourceType) && x.DestinationType.Equals(destinationType));
    foreach (var property in existingMaps.GetUnmappedPropertyNames())
    {
        expression.ForMember(property, opt => opt.Ignore());
    }
    return expression;
}

用法:

Mapper.CreateMap<SourceType, DestinationType>()
                .ForMember(prop => x.Property, opt => opt.MapFrom(src => src.OtherProperty))
                .IgnoreAllNonExisting();

更新:注意，在9.0版本Mapper静态API被删除

The only infromation about ignoring many of members is this thread - http://groups.google.com/group/automapper-users/browse_thread/thread/9928ce9f2ffa641f . I think you can use the trick used in ProvidingCommonBaseClassConfiguration to ignore common properties for similar classes. And there is no information about the "Ignore the rest" functionality. I've looked at the code before and it seems to me that will be very and very hard to add such functionality. Also you can try to use some attribute and mark with it ignored properties and add some generic/common code to ignore all marked properties.