我发现的最简单的方法(可能也是最有效的)是:

import boto3
from botocore.errorfactory import ClientError

s3 = boto3.client('s3')
try:
    s3.head_object(Bucket='bucket_name', Key='file_path')
except ClientError:
    # Not found
    pass

我不太喜欢在控制流中使用异常。这是在boto3中工作的另一种方法:

import boto3

s3 = boto3.resource('s3')
bucket = s3.Bucket('my-bucket')
key = 'dootdoot.jpg'
objs = list(bucket.objects.filter(Prefix=key))
if any([w.key == path_s3 for w in objs]):
    print("Exists!")
else:
    print("Doesn't exist")

S3_REGION="eu-central-1"
bucket="mybucket1"
name="objectname"

import boto3
from botocore.client import Config
client = boto3.client('s3',region_name=S3_REGION,config=Config(signature_version='s3v4'))
list = client.list_objects_v2(Bucket=bucket,Prefix=name)
for obj in list.get('Contents', []):
    if obj['Key'] == name: return True
return False

有一种简单的方法可以检查文件是否存在于S3桶中。我们不需要为此使用异常

sesssion = boto3.Session(aws_access_key_id, aws_secret_access_key)
s3 = session.client('s3')

object_name = 'filename'
bucket = 'bucketname'
obj_status = s3.list_objects(Bucket = bucket, Prefix = object_name)
if obj_status.get('Contents'):
    print("File exists")
else:
    print("File does not exists")

不仅是客户端，还有桶:

import boto3
import botocore
bucket = boto3.resource('s3', region_name='eu-west-1').Bucket('my-bucket')

try:
  bucket.Object('my-file').get()
except botocore.exceptions.ClientError as ex:
  if ex.response['Error']['Code'] == 'NoSuchKey':
    print('NoSuchKey')

import boto3
client = boto3.client('s3')
s3_key = 'Your file without bucket name e.g. abc/bcd.txt'
bucket = 'your bucket name'
content = client.head_object(Bucket=bucket,Key=s3_key)
    if content.get('ResponseMetadata',None) is not None:
        print "File exists - s3://%s/%s " %(bucket,s3_key) 
    else:
        print "File does not exist - s3://%s/%s " %(bucket,s3_key)