我对Mark Byers给出的代码做了一些修改。如果您有空目录，下面的函数也会添加它们。示例应该更清楚添加到zip的路径是什么。

#!/usr/bin/env python
import os
import zipfile

def addDirToZip(zipHandle, path, basePath=""):
    """
    Adding directory given by \a path to opened zip file \a zipHandle

    @param basePath path that will be removed from \a path when adding to archive

    Examples:
        # add whole "dir" to "test.zip" (when you open "test.zip" you will see only "dir")
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir')
        zipHandle.close()

        # add contents of "dir" to "test.zip" (when you open "test.zip" you will see only it's contents)
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir', 'dir')
        zipHandle.close()

        # add contents of "dir/subdir" to "test.zip" (when you open "test.zip" you will see only contents of "subdir")
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir/subdir', 'dir/subdir')
        zipHandle.close()

        # add whole "dir/subdir" to "test.zip" (when you open "test.zip" you will see only "subdir")
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir/subdir', 'dir')
        zipHandle.close()

        # add whole "dir/subdir" with full path to "test.zip" (when you open "test.zip" you will see only "dir" and inside it only "subdir")
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir/subdir')
        zipHandle.close()

        # add whole "dir" and "otherDir" (with full path) to "test.zip" (when you open "test.zip" you will see only "dir" and "otherDir")
        zipHandle = zipfile.ZipFile('test.zip', 'w')
        addDirToZip(zipHandle, 'dir')
        addDirToZip(zipHandle, 'otherDir')
        zipHandle.close()
    """
    basePath = basePath.rstrip("\\/") + ""
    basePath = basePath.rstrip("\\/")
    for root, dirs, files in os.walk(path):
        # add dir itself (needed for empty dirs
        zipHandle.write(os.path.join(root, "."))
        # add files
        for file in files:
            filePath = os.path.join(root, file)
            inZipPath = filePath.replace(basePath, "", 1).lstrip("\\/")
            #print filePath + " , " + inZipPath
            zipHandle.write(filePath, inZipPath)

以上是一个简单的函数，适用于简单的情况。你可以在我的Gist中找到更优雅的课程：https://gist.github.com/Eccenux/17526123107ca0ac28e6

现代Python（3.6+）使用pathlib模块对路径进行类似OOP的简洁处理，使用pathlib.Path.rglob（）进行递归globing。据我所知，这相当于乔治·V·莱利的回答：压缩压缩，最顶层的元素是目录，保持空目录，使用相对路径。

from pathlib import Path
from zipfile import ZIP_DEFLATED, ZipFile

from os import PathLike
from typing import Union


def zip_dir(zip_name: str, source_dir: Union[str, PathLike]):
    src_path = Path(source_dir).expanduser().resolve(strict=True)
    with ZipFile(zip_name, 'w', ZIP_DEFLATED) as zf:
        for file in src_path.rglob('*'):
            zf.write(file, file.relative_to(src_path.parent))

注意：如可选类型提示所示，zip_name不能是Path对象（将在3.6.2+中修复）。

前面的答案完全忽略了一点，即当您在Windows上运行代码时，使用os.path.join（）可以很容易地返回POSIX不兼容的路径。当使用Linux上的任何常用归档软件处理文件时，生成的归档文件将包含名称中带有反斜杠的文件，这不是您想要的。请改用path.as_posix（）作为arcname参数！

import zipfile
from pathlib import Path
with zipfile.ZipFile("archive.zip", "w", zipfile.ZIP_DEFLATED) as zf:
    for path in Path("include_all_of_this_folder").rglob("*"):
        zf.write(path, path.as_posix())

使用shutil，它是python标准库集的一部分。使用shutil非常简单（参见下面的代码）：

第一个参数：结果zip/tar文件的文件名，第二个参数：zip/tar，第三个参数：目录名

代码：

import shutil
shutil.make_archive('/home/user/Desktop/Filename','zip','/home/username/Desktop/Directory')

显而易见的方法是使用shutil，就像第二个顶级答案所说的那样，但如果出于某种原因，您仍然希望使用ZipFile，并且如果您在执行此操作时遇到一些问题（如Windows等中的ERR 13），您可以使用此修复程序：

import os
import zipfile

def retrieve_file_paths(dirName):
  filePaths = []
  for root, directories, files in os.walk(dirName):
    for filename in files:
        filePath = os.path.join(root, filename)
        filePaths.append(filePath)
  return filePaths
 
def main(dir_name, output_filename):
  filePaths = retrieve_file_paths(dir_name)
   
  zip_file = zipfile.ZipFile(output_filename+'.zip', 'w')
  with zip_file:
    for file in filePaths:
      zip_file.write(file)

main("my_dir", "my_dir_archived")

该方法递归地遍历给定文件夹中的每个子文件夹/文件，并将它们写入zip文件，而不是尝试直接压缩文件夹。

您可能想看看zipfile模块；文档位于http://docs.python.org/library/zipfile.html.

您可能还需要os.walk（）来索引目录结构。