不是最快的解决方案，但简单易懂:

DateTime d = DateTime.Now;
d = d.Date.AddHours(d.Hour).AddMinutes(d.Minute).AddSeconds(d.Second)

2上述解决方案的扩展方法

    public static bool LiesAfterIgnoringMilliseconds(this DateTime theDate, DateTime compareDate, DateTimeKind kind)
    {
        DateTime thisDate = new DateTime(theDate.Year, theDate.Month, theDate.Day, theDate.Hour, theDate.Minute, theDate.Second, kind);
        compareDate = new DateTime(compareDate.Year, compareDate.Month, compareDate.Day, compareDate.Hour, compareDate.Minute, compareDate.Second, kind);

        return thisDate > compareDate;
    }


    public static bool LiesAfterOrEqualsIgnoringMilliseconds(this DateTime theDate, DateTime compareDate, DateTimeKind kind)
    {
        DateTime thisDate = new DateTime(theDate.Year, theDate.Month, theDate.Day, theDate.Hour, theDate.Minute, theDate.Second, kind);
        compareDate = new DateTime(compareDate.Year, compareDate.Month, compareDate.Day, compareDate.Hour, compareDate.Minute, compareDate.Second, kind);

        return thisDate >= compareDate;
    }

用法:

bool liesAfter = myObject.DateProperty.LiesAfterOrEqualsIgnoringMilliseconds(startDateTime, DateTimeKind.Utc);

不是最快的解决方案，但简单易懂:

DateTime d = DateTime.Now;
d = d.Date.AddHours(d.Hour).AddMinutes(d.Minute).AddSeconds(d.Second)

下面是一个基于之前答案的扩展方法，它可以让你截断到任何分辨率…

用法:

DateTime myDateSansMilliseconds = myDate.Truncate(TimeSpan.TicksPerSecond);
DateTime myDateSansSeconds = myDate.Truncate(TimeSpan.TicksPerMinute)

类:

public static class DateTimeUtils
{
    /// <summary>
    /// <para>Truncates a DateTime to a specified resolution.</para>
    /// <para>A convenient source for resolution is TimeSpan.TicksPerXXXX constants.</para>
    /// </summary>
    /// <param name="date">The DateTime object to truncate</param>
    /// <param name="resolution">e.g. to round to nearest second, TimeSpan.TicksPerSecond</param>
    /// <returns>Truncated DateTime</returns>
    public static DateTime Truncate(this DateTime date, long resolution)
    {
        return new DateTime(date.Ticks - (date.Ticks % resolution), date.Kind);
    }
}

一种简单的阅读方法是……

//Remove milliseconds
DateTime date = DateTime.Now;
date = DateTime.ParseExact(date.ToString("yyyy-MM-dd HH:mm:ss"), "yyyy-MM-dd HH:mm:ss", null);

和更多的……

//Remove seconds
DateTime date = DateTime.Now;
date = DateTime.ParseExact(date.ToString("yyyy-MM-dd HH:mm"), "yyyy-MM-dd HH:mm", null);

//Remove minutes
DateTime date = DateTime.Now;
date = DateTime.ParseExact(date.ToString("yyyy-MM-dd HH"), "yyyy-MM-dd HH", null);

//and go on...

我知道这很容易理解，但是它缺乏性能。

DateTime d = DateTime.Now;
d = d.AddMilliseconds(-d.Millisecond);