您可以尝试这样做，但必须确定每个Column的值类型

List<MyClass> result = myDataTable.AsEnumerable().Select(x=> new MyClass(){
     Property1 = (string)x.Field<string>("ColumnName1"),
     Property2 = (int)x.Field<int>("ColumnName2"),
     Property3 = (bool)x.Field<bool>("ColumnName3"),    
});

IEnumerable<string> result = from myRow in dataTableResult.AsEnumerable()
                             select myRow["server"].ToString() ;

var results = from DataRow myRow in myDataTable.Rows
    where (int)myRow["RowNo"] == 1
    select myRow

在我的应用程序中，我发现使用LINQ到数据集的AsEnumerable()扩展数据表，如答案中所建议的是非常慢的。如果你对优化速度感兴趣，可以使用James Newtonking的Json。网上图书馆(http://james.newtonking.com/json/help/index.html)

// Serialize the DataTable to a json string
string serializedTable = JsonConvert.SerializeObject(myDataTable);    
Jarray dataRows = Jarray.Parse(serializedTable);

// Run the LINQ query
List<JToken> results = (from row in dataRows
                    where (int) row["ans_key"] == 42
                    select row).ToList();

// If you need the results to be in a DataTable
string jsonResults = JsonConvert.SerializeObject(results);
DataTable resultsTable = JsonConvert.DeserializeObject<DataTable>(jsonResults);

试试这个…

SqlCommand cmd = new SqlCommand( "Select * from Employee",con);
SqlDataReader dr = cmd.ExecuteReader( );
DataTable dt = new DataTable( "Employee" );
dt.Load( dr );
var Data = dt.AsEnumerable( );
var names = from emp in Data select emp.Field<String>( dt.Columns[1] );
foreach( var name in names )
{
    Console.WriteLine( name );
}

试试这个简单的问题:

var result=myDataTable.AsEnumerable().Where(myRow => myRow.Field<int>("RowNo") == 1);