您可以循环遍历第一个列表，对于不在第二个列表中但在第一个列表中的每一项，将其添加到第三个列表中。例句:

temp3 = []
for i in temp1:
    if i not in temp2:
        temp3.append(i)
print(temp3)

如果您想要更类似于变更集的东西……可以使用Counter

from collections import Counter

def diff(a, b):
  """ more verbose than needs to be, for clarity """
  ca, cb = Counter(a), Counter(b)
  to_add = cb - ca
  to_remove = ca - cb
  changes = Counter(to_add)
  changes.subtract(to_remove)
  return changes

lista = ['one', 'three', 'four', 'four', 'one']
listb = ['one', 'two', 'three']

In [127]: diff(lista, listb)
Out[127]: Counter({'two': 1, 'one': -1, 'four': -2})
# in order to go from lista to list b, you need to add a "two", remove a "one", and remove two "four"s

In [128]: diff(listb, lista)
Out[128]: Counter({'four': 2, 'one': 1, 'two': -1})
# in order to go from listb to lista, you must add two "four"s, add a "one", and remove a "two"

如果列表是对象而不是基本类型，这是一种方法。

代码更加明确，并给出了一个副本。 这可能不是一个有效的实现，但对于较小的对象列表来说是干净的。

a = [
    {'id1': 1, 'id2': 'A'},
    {'id1': 1, 'id2': 'B'},
    {'id1': 1, 'id2': 'C'},  # out
    {'id1': 2, 'id2': 'A'},
    {'id1': 2, 'id2': 'B'},  # out
]
b = [
    {'id1': 1, 'id2': 'A'},
    {'id1': 1, 'id2': 'B'},
    {'id1': 2, 'id2': 'A'},
]


def difference(a, b):
  for x in a:
    for y in b:
      if x['id1'] == y['id1'] and x['id2'] == y['id2']:
        x['is_removed'] = True

  c = [x for x in a if not x.get('is_removed', False)]
  return c


print(difference(a, b))

下面是@arkolec的回答，下面是一个用于比较列表、元组和集的实用程序类:

from difflib import SequenceMatcher

class ListDiffer:

    def __init__(self, left, right, strict:bool=False):
        assert isinstance(left, (list, tuple, set)), "left must be list, tuple or set"
        assert isinstance(right, (list, tuple, set)), "right must be list, tuple or set"
        self.l = list(left) if isinstance(left, (tuple, set)) else left
        self.r = list(right) if isinstance(left, (tuple, set)) else right

        if strict:
            assert isinstance(left, right.__class__), \
                f'left type ({left.__class__.__name__}) must equal right type ({right.__class__.__name__})'

        self.diffs = []
        self.equal = []

        for tag, i, j, k, l in SequenceMatcher(None, self.l, self.r).get_opcodes():
            if tag in ['delete', 'replace', 'insert']:
                self.diffs.append((tag, i, j, k, l))
            elif tag == 'equal':
                [self.equal.append(v) for v in left[i:j]]
                


    def has_diffs(self):
        return len(self.diffs) > 0


    def only_left(self):
        a = self.l[:]
        [a.remove(v) for v in self.equal]
        return a

    def only_right(self):
        a = self.r[:]
        [a.remove(v) for v in self.equal]
        return a


    def __str__(self, verbose:bool=False):
        iD = 0
        sb = []
        if verbose:
            sb.append(f"left: {self.l}\n")
            sb.append(f"right: {self.r}\n")
            sb.append(f"diffs: ")
        for tag, i, j, k, l in self.diffs:
            s = f"({iD})"
            if iD > 0: sb.append(' | ')
            if tag in ('delete', 'replace'): s = f'{s} l:{self.l[i:j]}'
            if tag in ('insert', 'replace'): s = f'{s} r:{self.r[k:l]}'
            sb.append(s)
            iD = iD + 1

        if verbose:
            sb.append(f"\nequal: {self.equal}")
        return ''.join(sb)

    def __repr__(self) -> str:
        return "<ListDiffer> {}".format(self.__str__())

用法:

left = ['a','b','c']
right = ['aa','b','c','d']
# right = ('aa','b','c','d')
ld = ListDiffer(left, right, strict=True)
print(f'ld.has_diffs(): {ld.has_diffs()}')
print(f'ld: {ld}')
print(f'ld.only_left(): {ld.only_left()}')
print(f'ld.only_right(): {ld.only_right()}')

输出:

ld.has_diffs(): True
ld: (0) l:['a'] r:['aa'] | (1) r:['d']
ld.only_left(): ['a']
ld.only_right(): ['aa', 'd']

我不能说性能，但你可以使用ld.only_left()来获得你正在寻找的结果。

这可能比马克的清单理解还要快:

list(itertools.filterfalse(set(temp2).__contains__, temp1))

最简单的方法，

使用设置().difference(设置())

list_a = [1,2,3]
list_b = [2,3]
print set(list_a).difference(set(list_b))

答案设置([1])

可以打印为列表，

print list(set(list_a).difference(set(list_b)))