Pieter Hintjens (ØMQ-project的创始人之一)表示，使用ØMQ并避免使用锁、互斥对象、事件等同步原语，是编写多线程程序最明智、最安全的方法:

http://zguide.zeromq.org/py:all#Multithreading-with-ZeroMQ

这包括告诉子线程，它应该取消它的工作。这可以通过为线程配备ØMQ-socket并轮询该套接字以获得一条表示它应该取消的消息来实现。

该链接还提供了一个使用ØMQ的多线程python代码示例。

虽然它相当古老，但对一些人来说这可能是一个方便的解决方案:

一个扩展线程模块功能的小模块—— 允许一个线程在另一个线程的上下文中引发异常 线程。通过触发SystemExit，你最终可以杀死python线程。

import threading
import ctypes     

def _async_raise(tid, excobj):
    res = ctypes.pythonapi.PyThreadState_SetAsyncExc(tid, ctypes.py_object(excobj))
    if res == 0:
        raise ValueError("nonexistent thread id")
    elif res > 1:
        # """if it returns a number greater than one, you're in trouble, 
        # and you should call it again with exc=NULL to revert the effect"""
        ctypes.pythonapi.PyThreadState_SetAsyncExc(tid, 0)
        raise SystemError("PyThreadState_SetAsyncExc failed")

class Thread(threading.Thread):
    def raise_exc(self, excobj):
        assert self.isAlive(), "thread must be started"
        for tid, tobj in threading._active.items():
            if tobj is self:
                _async_raise(tid, excobj)
                return

        # the thread was alive when we entered the loop, but was not found 
        # in the dict, hence it must have been already terminated. should we raise
        # an exception here? silently ignore?

    def terminate(self):
        # must raise the SystemExit type, instead of a SystemExit() instance
        # due to a bug in PyThreadState_SetAsyncExc
        self.raise_exc(SystemExit)

因此，它允许“线程在另一个线程的上下文中引发异常”，通过这种方式，被终止的线程可以处理终止，而无需定期检查中止标志。

然而，根据其原始来源，这段代码有一些问题。

The exception will be raised only when executing python bytecode. If your thread calls a native/built-in blocking function, the exception will be raised only when execution returns to the python code. There is also an issue if the built-in function internally calls PyErr_Clear(), which would effectively cancel your pending exception. You can try to raise it again. Only exception types can be raised safely. Exception instances are likely to cause unexpected behavior, and are thus restricted. For example: t1.raise_exc(TypeError) and not t1.raise_exc(TypeError("blah")). IMHO it's a bug, and I reported it as one. For more info, http://mail.python.org/pipermail/python-dev/2006-August/068158.html I asked to expose this function in the built-in thread module, but since ctypes has become a standard library (as of 2.5), and this feature is not likely to be implementation-agnostic, it may be kept unexposed.

实现一个线程是绝对可能的。方法，如下例代码所示:

import sys
import threading
import time


class StopThread(StopIteration):
    pass

threading.SystemExit = SystemExit, StopThread


class Thread2(threading.Thread):

    def stop(self):
        self.__stop = True

    def _bootstrap(self):
        if threading._trace_hook is not None:
            raise ValueError('Cannot run thread with tracing!')
        self.__stop = False
        sys.settrace(self.__trace)
        super()._bootstrap()

    def __trace(self, frame, event, arg):
        if self.__stop:
            raise StopThread()
        return self.__trace


class Thread3(threading.Thread):

    def _bootstrap(self, stop_thread=False):
        def stop():
            nonlocal stop_thread
            stop_thread = True
        self.stop = stop

        def tracer(*_):
            if stop_thread:
                raise StopThread()
            return tracer
        sys.settrace(tracer)
        super()._bootstrap()

###############################################################################


def main():
    test1 = Thread2(target=printer)
    test1.start()
    time.sleep(1)
    test1.stop()
    test1.join()
    test2 = Thread2(target=speed_test)
    test2.start()
    time.sleep(1)
    test2.stop()
    test2.join()
    test3 = Thread3(target=speed_test)
    test3.start()
    time.sleep(1)
    test3.stop()
    test3.join()


def printer():
    while True:
        print(time.time() % 1)
        time.sleep(0.1)


def speed_test(count=0):
    try:
        while True:
            count += 1
    except StopThread:
        print('Count =', count)

if __name__ == '__main__':
    main()

Thread3类运行代码的速度似乎比Thread2类快大约33%。

在Python中，你不能直接杀死一个线程。

如果你不是真的需要Thread(!)，你可以做的，而不是使用threading包，是使用 多处理包。在这里，要终止一个进程，你可以简单地调用方法:

yourProcess.terminate()  # kill the process!

Python将终止您的进程(在Unix上通过SIGTERM信号，而在Windows上通过TerminateProcess()调用)。注意在使用队列或管道时使用它!(可能会破坏队列/管道中的数据)

注意，多处理。事件和多处理。信号量的工作方式与线程完全相同。事件和线程。信号量分别。事实上，前者是后者的克隆。

如果你真的需要使用一个线程，没有办法直接杀死它。但是，您可以使用“守护线程”。事实上，在Python中，线程可以被标记为守护进程:

yourThread.daemon = True  # set the Thread as a "daemon thread"

当没有活动的非守护进程线程时，主程序将退出。换句话说，当主线程(当然是非守护线程)完成其操作时，即使仍有一些守护线程在工作，程序也将退出。

注意，在调用start()方法之前，有必要将线程设置为守护进程!

当然，你可以，也应该在多进程中使用daemon。在这里，当主进程退出时，它将尝试终止其所有守护子进程。

最后，请注意sys.exit()和os.kill()不是选项。

Python版本:3.8

使用守护线程来执行我们想要的，如果我们想要终止守护线程，我们只需要让父线程退出，然后系统就会终止父线程创建的守护线程。

还支持协程和协程函数。

def main():
    start_time = time.perf_counter()
    t1 = ExitThread(time.sleep, (10,), debug=False)
    t1.start()
    time.sleep(0.5)
    t1.exit()
    try:
        print(t1.result_future.result())
    except concurrent.futures.CancelledError:
        pass
    end_time = time.perf_counter()
    print(f"time cost {end_time - start_time:0.2f}")

下面是ExitThread源代码

import concurrent.futures
import threading
import typing
import asyncio


class _WorkItem(object):
    """ concurrent\futures\thread.py

    """

    def __init__(self, future, fn, args, kwargs, *, debug=None):
        self._debug = debug
        self.future = future
        self.fn = fn
        self.args = args
        self.kwargs = kwargs

    def run(self):
        if self._debug:
            print("ExitThread._WorkItem run")
        if not self.future.set_running_or_notify_cancel():
            return

        try:
            coroutine = None
            if asyncio.iscoroutinefunction(self.fn):
                coroutine = self.fn(*self.args, **self.kwargs)
            elif asyncio.iscoroutine(self.fn):
                coroutine = self.fn
            if coroutine is None:
                result = self.fn(*self.args, **self.kwargs)
            else:
                result = asyncio.run(coroutine)
            if self._debug:
                print("_WorkItem done")
        except BaseException as exc:
            self.future.set_exception(exc)
            # Break a reference cycle with the exception 'exc'
            self = None
        else:
            self.future.set_result(result)


class ExitThread:
    """ Like a stoppable thread

    Using coroutine for target then exit before running may cause RuntimeWarning.

    """

    def __init__(self, target: typing.Union[typing.Coroutine, typing.Callable] = None
                 , args=(), kwargs={}, *, daemon=None, debug=None):
        #
        self._debug = debug
        self._parent_thread = threading.Thread(target=self._parent_thread_run, name="ExitThread_parent_thread"
                                               , daemon=daemon)
        self._child_daemon_thread = None
        self.result_future = concurrent.futures.Future()
        self._workItem = _WorkItem(self.result_future, target, args, kwargs, debug=debug)
        self._parent_thread_exit_lock = threading.Lock()
        self._parent_thread_exit_lock.acquire()
        self._parent_thread_exit_lock_released = False  # When done it will be True
        self._started = False
        self._exited = False
        self.result_future.add_done_callback(self._release_parent_thread_exit_lock)

    def _parent_thread_run(self):
        self._child_daemon_thread = threading.Thread(target=self._child_daemon_thread_run
                                                     , name="ExitThread_child_daemon_thread"
                                                     , daemon=True)
        self._child_daemon_thread.start()
        # Block manager thread
        self._parent_thread_exit_lock.acquire()
        self._parent_thread_exit_lock.release()
        if self._debug:
            print("ExitThread._parent_thread_run exit")

    def _release_parent_thread_exit_lock(self, _future):
        if self._debug:
            print(f"ExitThread._release_parent_thread_exit_lock {self._parent_thread_exit_lock_released} {_future}")
        if not self._parent_thread_exit_lock_released:
            self._parent_thread_exit_lock_released = True
            self._parent_thread_exit_lock.release()

    def _child_daemon_thread_run(self):
        self._workItem.run()

    def start(self):
        if self._debug:
            print(f"ExitThread.start {self._started}")
        if not self._started:
            self._started = True
            self._parent_thread.start()

    def exit(self):
        if self._debug:
            print(f"ExitThread.exit exited: {self._exited} lock_released: {self._parent_thread_exit_lock_released}")
        if self._parent_thread_exit_lock_released:
            return
        if not self._exited:
            self._exited = True
            if not self.result_future.cancel():
                if self.result_future.running():
                    self.result_future.set_exception(concurrent.futures.CancelledError())

这是一个糟糕的答案，请看评论

以下是如何做到这一点:

from threading import *

...

for thread in enumerate():
    if thread.isAlive():
        try:
            thread._Thread__stop()
        except:
            print(str(thread.getName()) + ' could not be terminated'))

给它几秒钟，然后你的线程应该停止。还要检查thread._Thread__delete()方法。

为了方便，我建议使用thread.quit()方法。例如，如果你的线程中有一个套接字，我建议在你的套接字句柄类中创建一个quit()方法，终止套接字，然后在你的quit()中运行一个thread. _thread__stop()。