为了让Shimmy的回答更清楚:

var mimeType = MimeMapping.GetMimeMapping(fileName);

System.Web.dll v4.5开发

// Summary:
//     Returns the MIME mapping for the specified file name.
//
// Parameters:
//   fileName:
//     The file name that is used to determine the MIME type.
public static string GetMimeMapping(string fileName);

Bryan Denny上面的帖子不适合我，因为不是所有的扩展在注册表中都有一个“内容类型”子键。我不得不调整代码如下:

private string GetMimeType(string sFileName)
{
  // Get file extension and if it is empty, return unknown
  string sExt = Path.GetExtension(sFileName);
  if (string.IsNullOrEmpty(sExt)) return "Unknown file type";

  // Default type is "EXT File"
  string mimeType = string.Format("{0} File", sExt.ToUpper().Replace(".", ""));

  // Open the registry key for the extension under HKEY_CLASSES_ROOT and return default if it doesn't exist
  Microsoft.Win32.RegistryKey regKey = Microsoft.Win32.Registry.ClassesRoot.OpenSubKey(sExt);
  if (regKey == null) return mimeType;

  // Get the "(Default)" value and re-open the key for that value
  string sSubType = regKey.GetValue("").ToString();
  regKey = Microsoft.Win32.Registry.ClassesRoot.OpenSubKey(sSubType);

  // If it exists, get the "(Default)" value of the new key
  if (regKey?.GetValue("") != null) mimeType = regKey.GetValue("").ToString();

  // Return the value
  return mimeType;
}

现在它可以为我所有注册的文件类型和未注册的或通用的文件类型(如JPG等)。

大多数解决方案都在工作，但为什么要这么努力，而我们也可以很容易地获得mime类型。 在系统。Web程序集，有从文件名获取mime类型的方法。 例如:

string mimeType = MimeMapping.GetMimeMapping(filename);

为了使这篇文章更全面，对于。net核心开发人员有FileExtensionContentTypeProvider类，它涵盖了官方的MIME内容类型。

它在幕后工作——根据文件扩展名在Http响应头中设置ContentType。

如果您需要特殊的MIME类型，请参阅自定义MIME类型的示例:

public void Configure(IApplicationBuilder app)
{
    // Set up custom content types -associating file extension to MIME type
    var provider = new FileExtensionContentTypeProvider();
    // Add new mappings
    provider.Mappings[".myapp"] = "application/x-msdownload";
    provider.Mappings[".htm3"] = "text/html";
    provider.Mappings[".image"] = "image/png";
    // Replace an existing mapping
    provider.Mappings[".rtf"] = "application/x-msdownload";
    // Remove MP4 videos.
    provider.Mappings.Remove(".mp4");

    app.UseStaticFiles(new StaticFileOptions()
    {
        FileProvider = new PhysicalFileProvider(
            Path.Combine(Directory.GetCurrentDirectory(), @"wwwroot", "images")),
        RequestPath = new PathString("/MyImages"),
        ContentTypeProvider = provider
    });

    app.UseDirectoryBrowser(new DirectoryBrowserOptions()
    {
        FileProvider = new PhysicalFileProvider(
            Path.Combine(Directory.GetCurrentDirectory(), @"wwwroot", "images")),
        RequestPath = new PathString("/MyImages")
    });
}

.NET Core获取MimeType的方法:

添加依赖关系

Microsoft.AspNetCore.StaticFiles

private string GetMimeType(string fileName)
{
    var provider = new FileExtensionContentTypeProvider();
    if (!provider.TryGetContentType(fileName, out var contentType))
    {
        contentType = "application/octet-stream";
    }
    return contentType;            
}

您可以在注册表中找到这些信息。例如，.pdf文件的MIME类型可以在键HKEY_CLASSES_ROOT\.pdf中找到，在值"Content type "中:

string mimeType = Registry.GetValue(@"HKEY_CLASSES_ROOT\.pdf", "Content Type", null) as string;