如果另一个实例已经在运行，则此示例将在5秒后退出。

// unique id for global mutex - Global prefix means it is global to the machine
const string mutex_id = "Global\\{B1E7934A-F688-417f-8FCB-65C3985E9E27}";

static void Main(string[] args)
{

    using (var mutex = new Mutex(false, mutex_id))
    {
        try
        {
            try
            {
                if (!mutex.WaitOne(TimeSpan.FromSeconds(5), false))
                {
                    Console.WriteLine("Another instance of this program is running");
                    Environment.Exit(0);
                }
            }
            catch (AbandonedMutexException)
            {
                // Log the fact the mutex was abandoned in another process, it will still get aquired
            }

            // Perform your work here.
        }
        finally
        {
            mutex.ReleaseMutex();
        }
    }
}

我想要确保这是存在的，因为它很难做到正确:

using System.Runtime.InteropServices;   //GuidAttribute
using System.Reflection;                //Assembly
using System.Threading;                 //Mutex
using System.Security.AccessControl;    //MutexAccessRule
using System.Security.Principal;        //SecurityIdentifier

static void Main(string[] args)
{
    // get application GUID as defined in AssemblyInfo.cs
    string appGuid =
        ((GuidAttribute)Assembly.GetExecutingAssembly().
            GetCustomAttributes(typeof(GuidAttribute), false).
                GetValue(0)).Value.ToString();

    // unique id for global mutex - Global prefix means it is global to the machine
    string mutexId = string.Format( "Global\\{{{0}}}", appGuid );

    // Need a place to store a return value in Mutex() constructor call
    bool createdNew;

    // edited by Jeremy Wiebe to add example of setting up security for multi-user usage
    // edited by 'Marc' to work also on localized systems (don't use just "Everyone") 
    var allowEveryoneRule =
        new MutexAccessRule( new SecurityIdentifier( WellKnownSidType.WorldSid
                                                   , null)
                           , MutexRights.FullControl
                           , AccessControlType.Allow
                           );
    var securitySettings = new MutexSecurity();
    securitySettings.AddAccessRule(allowEveryoneRule);

   // edited by MasonGZhwiti to prevent race condition on security settings via VanNguyen
    using (var mutex = new Mutex(false, mutexId, out createdNew, securitySettings))
    {
        // edited by acidzombie24
        var hasHandle = false;
        try
        {
            try
            {
                // note, you may want to time out here instead of waiting forever
                // edited by acidzombie24
                // mutex.WaitOne(Timeout.Infinite, false);
                hasHandle = mutex.WaitOne(5000, false);
                if (hasHandle == false)
                    throw new TimeoutException("Timeout waiting for exclusive access");
            }
            catch (AbandonedMutexException)
            {
                // Log the fact that the mutex was abandoned in another process,
                // it will still get acquired
                hasHandle = true;
            }

            // Perform your work here.
        }
        finally
        {
            // edited by acidzombie24, added if statement
            if(hasHandle)
                mutex.ReleaseMutex();
        }
    }
}

如果另一个实例已经在运行，则此示例将在5秒后退出。

// unique id for global mutex - Global prefix means it is global to the machine
const string mutex_id = "Global\\{B1E7934A-F688-417f-8FCB-65C3985E9E27}";

static void Main(string[] args)
{

    using (var mutex = new Mutex(false, mutex_id))
    {
        try
        {
            try
            {
                if (!mutex.WaitOne(TimeSpan.FromSeconds(5), false))
                {
                    Console.WriteLine("Another instance of this program is running");
                    Environment.Exit(0);
                }
            }
            catch (AbandonedMutexException)
            {
                // Log the fact the mutex was abandoned in another process, it will still get aquired
            }

            // Perform your work here.
        }
        finally
        {
            mutex.ReleaseMutex();
        }
    }
}

一个没有WaitOne的解决方案，因为它会导致一个AbandonedMutexException。 这个解决方案使用互斥量构造函数返回createdNew布尔值来检查互斥量是否已经创建。它还使用GetType()。GUID，因此重命名一个可执行文件不允许多个实例。

全局互斥与局部互斥参见: https://learn.microsoft.com/en-us/dotnet/api/system.threading.mutex?view=netframework-4.8

private Mutex mutex;
private bool mutexCreated;

public App()
{
    string mutexId = $"Global\\{GetType().GUID}";
    mutex = new Mutex(true, mutexId, out mutexCreated);
}

protected override void OnStartup(StartupEventArgs e)
{
    base.OnStartup(e);
    if (!mutexCreated)
    {
        MessageBox.Show("Already started!");
        Shutdown();
    }
}

因为互斥锁实现了IDisposable，所以它被自动释放，但是为了完整性，调用dispose:

protected override void OnExit(ExitEventArgs e)
{
    base.OnExit(e);
    mutex.Dispose();
}

将所有内容移动到基类中，并从接受的答案中添加allowEveryoneRule。还添加了ReleaseMutex，虽然它看起来不像真的需要，因为它是由操作系统自动释放的(如果应用程序崩溃了，你需要重新启动ReleaseMutex吗?)

public class SingleApplication : Application
{
    private Mutex mutex;
    private bool mutexCreated;

    public SingleApplication()
    {
        string mutexId = $"Global\\{GetType().GUID}";

        MutexAccessRule allowEveryoneRule = new MutexAccessRule(
            new SecurityIdentifier(WellKnownSidType.WorldSid, null),
            MutexRights.FullControl, 
            AccessControlType.Allow);
        MutexSecurity securitySettings = new MutexSecurity();
        securitySettings.AddAccessRule(allowEveryoneRule);

        // initiallyOwned: true == false + mutex.WaitOne()
        mutex = new Mutex(initiallyOwned: true, mutexId, out mutexCreated, securitySettings);        
    }

    protected override void OnExit(ExitEventArgs e)
    {
        base.OnExit(e);
        if (mutexCreated)
        {
            try
            {
                mutex.ReleaseMutex();
            }
            catch (ApplicationException ex)
            {
                MessageBox.Show(ex.Message, ex.GetType().FullName, MessageBoxButton.OK, MessageBoxImage.Error);
            }
        }
        mutex.Dispose();
    }

    protected override void OnStartup(StartupEventArgs e)
    {
        base.OnStartup(e);
        if (!mutexCreated)
        {
            MessageBox.Show("Already started!");
            Shutdown();
        }
    }
}

Mutex和WinApi CreateMutex()都不适合我。

另一种解决方案:

static class Program
{
    [STAThread]
    static void Main()
    {
        if (SingleApplicationDetector.IsRunning()) {
            return;
        }

        Application.Run(new MainForm());

        SingleApplicationDetector.Close();
    }
}

和SingleApplicationDetector:

using System;
using System.Reflection;
using System.Runtime.InteropServices;
using System.Security.AccessControl;
using System.Threading;

public static class SingleApplicationDetector
{
    public static bool IsRunning()
    {
        string guid = ((GuidAttribute)Assembly.GetExecutingAssembly().GetCustomAttributes(typeof(GuidAttribute), false).GetValue(0)).Value.ToString();
        var semaphoreName = @"Global\" + guid;
        try {
            __semaphore = Semaphore.OpenExisting(semaphoreName, SemaphoreRights.Synchronize);

            Close();
            return true;
        }
        catch (Exception ex) {
            __semaphore = new Semaphore(0, 1, semaphoreName);
            return false;
        }
    }

    public static void Close()
    {
        if (__semaphore != null) {
            __semaphore.Close();
            __semaphore = null;
        }
    }

    private static Semaphore __semaphore;
}

使用信号量而不是互斥锁的原因:

Mutex类强制线程标识，因此只有获得互斥锁的线程才能释放它。相反，Semaphore类并不强制执行线程标识。 < < System.Threading.Mutex

裁判:Semaphore.OpenExisting ()

使用已接受的答案，我创建了一个帮助类，以便您可以以类似于使用Lock语句的方式使用它。只是想分享一下。

使用:

using (new SingleGlobalInstance(1000)) //1000ms timeout on global lock
{
    //Only 1 of these runs at a time
    RunSomeStuff();
}

helper类:

class SingleGlobalInstance : IDisposable
{
    //edit by user "jitbit" - renamed private fields to "_"
    public bool _hasHandle = false;
    Mutex _mutex;

    private void InitMutex()
    {
        string appGuid = ((GuidAttribute)Assembly.GetExecutingAssembly().GetCustomAttributes(typeof(GuidAttribute), false).GetValue(0)).Value;
        string mutexId = string.Format("Global\\{{{0}}}", appGuid);
        _mutex = new Mutex(false, mutexId);

        var allowEveryoneRule = new MutexAccessRule(new SecurityIdentifier(WellKnownSidType.WorldSid, null), MutexRights.FullControl, AccessControlType.Allow);
        var securitySettings = new MutexSecurity();
        securitySettings.AddAccessRule(allowEveryoneRule);
        _mutex.SetAccessControl(securitySettings);
    }

    public SingleGlobalInstance(int timeOut)
    {
        InitMutex();
        try
        {
            if(timeOut < 0)
                _hasHandle = _mutex.WaitOne(Timeout.Infinite, false);
            else
                _hasHandle = _mutex.WaitOne(timeOut, false);

            if (_hasHandle == false)
                throw new TimeoutException("Timeout waiting for exclusive access on SingleInstance");
        }
        catch (AbandonedMutexException)
        {
            _hasHandle = true;
        }
    }


    public void Dispose()
    {
        if (_mutex != null)
        {
            if (_hasHandle)
                _mutex.ReleaseMutex();
            _mutex.Close();
        }
    }
}