对于那些迁移到iOS 8的人，这里有一个Swift的类扩展:

extension UILabel {

    func autoresize() {
        if let textNSString: NSString = self.text {
            let rect = textNSString.boundingRectWithSize(CGSizeMake(self.frame.size.width, CGFloat.max),
                options: NSStringDrawingOptions.UsesLineFragmentOrigin,
                attributes: [NSFontAttributeName: self.font],
                context: nil)
            self.frame = CGRectMake(self.frame.origin.x, self.frame.origin.y, self.frame.size.width, rect.height)
        }
    }

}

myLabel.text = "your very long text"
myLabel.numberOfLines = 0
myLabel.lineBreakMode = NSLineBreakMode.ByWordWrapping

请在故事板中为可用性设置约束，包括左上右下

谢谢大家的帮助，这是我尝试的代码，这是为我工作

   UILabel *instructions = [[UILabel alloc]initWithFrame:CGRectMake(10, 225, 300, 180)];
   NSString *text = @"First take clear picture and then try to zoom in to fit the ";
   instructions.text = text;
   instructions.textAlignment = UITextAlignmentCenter;
   instructions.lineBreakMode = NSLineBreakByWordWrapping;
   [instructions setTextColor:[UIColor grayColor]];

   CGSize expectedLabelSize = [text sizeWithFont:instructions.font 
                                constrainedToSize:instructions.frame.size
                                    lineBreakMode:UILineBreakModeWordWrap];

    CGRect newFrame = instructions.frame;
    newFrame.size.height = expectedLabelSize.height;
    instructions.frame = newFrame;
    instructions.numberOfLines = 0;
    [instructions sizeToFit];
    [self addSubview:instructions];

当自动布局被启用时，调整大小不工作:)

基于Swift 4及以上答案的UILabel扩展

extension UILabel {

    func retrieveTextHeight () -> CGFloat {
        let attributedText = NSAttributedString(string: self.text!, attributes: [NSFontAttributeName:self.font])

        let rect = attributedText.boundingRect(with: CGSize(width: self.frame.size.width, height: CGFloat.greatestFiniteMagnitude), options: .usesLineFragmentOrigin, context: nil)

        return ceil(rect.size.height)
    }

}

可以这样使用:

self.labelHeightConstraint.constant = self.label.retrieveTextHeight()

NSString *str = @"Please enter your text......";
CGSize lblSize = [str sizeWithFont:[UIFont systemFontOfSize:15] constrainedToSize: CGSizeMake(200.0f, 600.0f) lineBreakMode: NSLineBreakByWordWrapping];

UILabel *label = [[UILabel alloc]init];
label.frame = CGRectMake(60, 20, 200, lblSize.height);
label.numberOfLines = 0;
label.lineBreakMode = NSLineBreakByWordWrapping;
label.font = [UIFont systemFontOfSize:15];
label.text = str;
label.backgroundColor = [UIColor clearColor];
[label sizeToFit];
[self.view addSubview:label];