这里似乎有一些相关信息:

在ASP中将msword文档转换为PDF。网

此外，由于Office 2007具有发布到PDF的功能，我猜你可以使用办公自动化在Word 2007中打开*. doc文件并另存为PDF。我不太喜欢办公室自动化，因为它很慢，而且容易挂起来，但我只是把它放在那里……

使用Microsoft.Office.Interop.Word将WORD转换为PDF格式的简单代码和解决方案

using Word = Microsoft.Office.Interop.Word;

private void convertDOCtoPDF()
{

  object misValue = System.Reflection.Missing.Value;
  String  PATH_APP_PDF = @"c:\..\MY_WORD_DOCUMENT.pdf"

  var WORD = new Word.Application();

  Word.Document doc   = WORD.Documents.Open(@"c:\..\MY_WORD_DOCUMENT.docx");
  doc.Activate();

  doc.SaveAs2(@PATH_APP_PDF, Word.WdSaveFormat.wdFormatPDF, misValue, misValue, misValue, 
  misValue, misValue, misValue, misValue, misValue, misValue, misValue);

  doc.Close();
  WORD.Quit();


  releaseObject(doc);
  releaseObject(WORD);

}

添加这个过程来释放内存:

private void releaseObject(object obj)
{
  try
  {
      System.Runtime.InteropServices.Marshal.ReleaseComObject(obj);
      obj = null;
  }
  catch (Exception ex)
  {
      //TODO
  }
  finally
  {
     GC.Collect();
  }
}

只是想补充一点，我用的是微软。互操作库，特别是ExportAsFixedFormat函数，我没有看到在这个线程中使用。

using Microsoft.Office.Interop.Word;
using System.Runtime.InteropServices;
using System.IO;
using Microsoft.Office.Core;

Application app;

public string CreatePDF(string path, string exportDir)
{
    Application app = new Application();
    app.DisplayAlerts = WdAlertLevel.wdAlertsNone;
    app.Visible = true;

    var objPresSet = app.Documents;
    var objPres = objPresSet.Open(path, MsoTriState.msoTrue, MsoTriState.msoTrue, MsoTriState.msoFalse);

    var pdfFileName = Path.ChangeExtension(path, ".pdf");
    var pdfPath = Path.Combine(exportDir, pdfFileName);

    try
    {
        objPres.ExportAsFixedFormat(
            pdfPath,
            WdExportFormat.wdExportFormatPDF,
            false,
            WdExportOptimizeFor.wdExportOptimizeForPrint,
            WdExportRange.wdExportAllDocument
        );
    }
    catch
    {
        pdfPath = null;
    }
    finally
    {
        objPres.Close();
    }
    return pdfPath;
}

我经历了Word转PDF的痛苦，有人把我的10000字文件转换成PDF。现在我在c#和使用Word互操作，但它很慢，如果我试图使用PC在所有崩溃。非常令人沮丧。

这让我发现我可以抛弃互操作和他们的缓慢.....我使用的Excel (EPPLUS)，然后我发现你可以得到一个叫做Spire的免费工具，允许转换为PDF…限制!

http://www.e-iceblue.com/Introduce/free-doc-component.html#.VtAg4PmLRhE

为vb.net用户总结一下，免费选项(必须安装office):

microsoftofficeassemblies下载:

2010年的Pia办公室 皮娅竞选2007年总统 添加对Microsoft.Office.Interop.Word.Application的引用 在Microsoft.Office.Interop.Word.Application中添加using或import (vb.net)语句

VB。净的例子:

        Dim word As Application = New Application()
        Dim doc As Document = word.Documents.Open("c:\document.docx")
        doc.Activate()
        doc.SaveAs2("c:\document.pdf", WdSaveFormat.wdFormatPDF)
        doc.Close()

Microsoft PDF add-in for word seems to be the best solution for now but you should take into consideration that it does not convert all word documents correctly to pdf and in some cases you will see huge difference between the word and the output pdf. Unfortunately I couldn't find any api that would convert all word documents correctly. The only solution I found to ensure the conversion was 100% correct was by converting the documents through a printer driver. The downside is that documents are queued and converted one by one, but you can be sure the resulted pdf is exactly the same as word document layout. I personally preferred using UDC (Universal document converter) and installed Foxit Reader(free version) on server too then printed the documents by starting a "Process" and setting its Verb property to "print". You can also use FileSystemWatcher to set a signal when the conversion has completed.