如果用户正在与另一个应用程序交互，则可能无法将您的应用程序放在前面。作为一般规则，只有当进程已经是前台进程时，该进程才能期望设置前台窗口。(微软在SetForegroundWindow() MSDN条目中记录了限制。)这是因为:

The user "owns" the foreground. For example, it would be extremely annoying if another program stole the foreground while the user is typing, at the very least interrupting her workflow, and possibly causing unintended consequences as her keystrokes meant for one application are misinterpreted by the offender until she notices the change. Imagine that each of two programs checks to see if its window is the foreground and attempts to set it to the foreground if it is not. As soon as the second program is running, the computer is rendered useless as the foreground bounces between the two at every task switch.

我知道这是一个很晚的答案，也许对研究人员有帮助

 if (!WindowName.IsVisible)
 {
     WindowName.Show();
     WindowName.Activate();
 }

如果你试图隐藏窗口，例如你最小化窗口，我发现使用

    this.Hide();

将隐藏它正确，然后简单地使用

    this.Show();

然后将窗口再次显示为最上面的项目。

既然这是个热门话题…以下是对我有效的方法。如果我不这样做，我就会得到错误，因为如果你看不到窗口，Activate()就会出错。

Xaml:

<Window .... 
        Topmost="True" 
        .... 
        ContentRendered="mainWindow_ContentRendered"> .... </Window>

后台代码:

private void mainWindow_ContentRendered(object sender, EventArgs e)
{
    this.Topmost = false;
    this.Activate();
    _UsernameTextBox.Focus();
}

这是唯一能让窗口在顶部显示的方法。然后激活它，这样你就可以在框中输入，而不必用鼠标设置焦点。control.Focus()不会工作，除非窗口是Active();

这是上面几个简单有效的建议的结合。它只在那些事件触发时才出现在前面，因此事件之后弹出的任何窗口当然都会保持在顶部。

public partial class MainWindow : Window
{
    protected override void OnContentRendered(EventArgs e)
    {
        base.OnContentRendered(e);

        Topmost = true;
        Topmost = false;
    }
    protected override void OnInitialized(EventArgs e)
    {
        base.OnInitialized(e);

        Topmost = true;
        Topmost = false;
    }

    ....
}

如果你需要窗口在第一次加载时在前面，那么你应该使用以下方法:

private void Window_ContentRendered(object sender, EventArgs e)
{
    this.Topmost = false;
}

private void Window_Initialized(object sender, EventArgs e)
{
    this.Topmost = true;
}

或者重写方法:

protected override void OnContentRendered(EventArgs e)
{
    base.OnContentRendered(e);
    Topmost = false;
}

protected override void OnInitialized(EventArgs e)
{
    base.OnInitialized(e);
    Topmost = true;
}