其他人已经提到了圆括号方法，但我想补充一点，使用圆括号时，允许内联注释。

对每个片段的注释：

nursery_rhyme = (
    'Mary had a little lamb,'          # Comments are great!
    'its fleece was white as snow.'
    'And everywhere that Mary went,'
    'her sheep would surely go.'       # What a pesky sheep.
)

继续后不允许注释：

使用反斜杠行延续符（\）时，不允许使用注释。您将收到一个SyntaxError：一行接一行的连续字符错误。

nursery_rhyme = 'Mary had a little lamb,' \  # These comments
    'its fleece was white as snow.'       \  # are invalid!
    'And everywhere that Mary went,'      \
    'her sheep would surely go.'
# => SyntaxError: unexpected character after line continuation character

Regex字符串的更好注释：

基于以下示例https://docs.python.org/3/library/re.html#re.VERBOSE,

a = re.compile(
    r'\d+'  # the integral part
    r'\.'   # the decimal point
    r'\d*'  # some fractional digits
)

# Using VERBOSE flag, IDE usually can't syntax highight the string comment.
a = re.compile(r"""\d +  # the integral part
                   \.    # the decimal point
                   \d *  # some fractional digits""", re.X)

结合以下观点：

Levon或Jesse、Faheel和ddrscott

根据我的格式建议，您可以将查询写成：

query = ('SELECT'
             ' action.descr as "action"'
             ',role.id as role_id'
             ',role.descr as role'
         ' FROM'
             ' public.role_action_def'
             ',public.role'
             ',public.record_def'
             ',public.action'
         ' WHERE'
             ' role.id = role_action_def.role_id'
             ' AND'
             ' record_def.id = role_action_def.def_id'
             ' AND'
             ' action.id = role_action_def.action_id'
             ' AND'
             ' role_action_def.account_id = ?' # account_id
             ' AND'
             ' record_def.account_id = ?'      # account_id
             ' AND'
             ' def_id = ?'                     # def_id
         )

 vars = (account_id, account_id, def_id)     # A tuple of the query variables
 cursor.execute(query, vars)                 # Using Python's sqlite3 module

或类似：

vars = []
query = ('SELECT'
             ' action.descr as "action"'
             ',role.id as role_id'
             ',role.descr as role'
         ' FROM'
             ' public.role_action_def'
             ',public.role'
             ',public.record_def'
             ',public.action'
         ' WHERE'
             ' role.id = role_action_def.role_id'
             ' AND'
             ' record_def.id = role_action_def.def_id'
             ' AND'
             ' action.id = role_action_def.action_id'
             ' AND'
             ' role_action_def.account_id = '
                 vars.append(account_id) or '?'
             ' AND'
             ' record_def.account_id = '
                 vars.append(account_id) or '?'
             ' AND'
             ' def_id = '
                 vars.append(def_id) or '?'
         )

 cursor.execute(query, tuple(vars))  # Using Python's sqlite3 module

与“IN”和“vars.extend（options）”或“n_options（len（option））”一起使用可能很有趣，其中：

def n_options(count):
    return '(' + ','.join(count*'?') + ')'

或者从darkcaline那里得到的提示是，您可能仍然会在使用前导空格和分隔符以及命名占位符时出错：

SPACE_SEP = ' '
COMMA_SEP = ', '
AND_SEP   = ' AND '

query = SPACE_SEP.join((
    'SELECT',
        COMMA_SEP.join((
        'action.descr as "action"',
        'role.id as role_id',
        'role.descr as role',
        )),
    'FROM',
        COMMA_SEP.join((
        'public.role_action_def',
        'public.role',
        'public.record_def',
        'public.action',
        )),
    'WHERE',
        AND_SEP.join((
        'role.id = role_action_def.role_id',
        'record_def.id = role_action_def.def_id',
        'action.id = role_action_def.action_id',
        'role_action_def.account_id = :account_id',
        'record_def.account_id = :account_id',
        'def_id = :def_id',
        )),
    ))

vars = {'account_id':account_id,'def_id':def_id}  # A dictionary of the query variables
cursor.execute(query, vars)                       # Using Python's sqlite3 module

请参阅Cursor.execute-function的文档。

“这是[最Python]的方式！”-。。。

我发现，当构建长字符串时，您通常会做一些类似于构建SQL查询的事情，在这种情况下，这是最好的：

query = ' '.join((  # Note double parentheses. join() takes an iterable
    "SELECT foo",
    "FROM bar",
    "WHERE baz",
))

Levon的建议很好，但可能容易出错：

query = (
    "SELECT foo"
    "FROM bar"
    "WHERE baz"
)

query == "SELECT fooFROM barWHERE baz"  # Probably not what you want

我发现自己对这个很满意：

string = """This is a
very long string,
containing commas,
that I split up
for readability""".replace('\n',' ')

我认为当代码（例如，变量）缩进并且输出字符串应该是单行（没有换行）时，另一个选项更可读：

def some_method():

    long_string = """
A presumptuous long string
which looks a bit nicer
in a text editor when
written over multiple lines
""".strip('\n').replace('\n', ' ')

    return long_string

您还可以将SQL语句放置在单独的文件action.SQL中，并使用以下命令将其加载到.py文件中：

with open('action.sql') as f:
   query = f.read()

因此，SQL语句将与Python代码分离。如果SQL语句中有需要从Python填充的参数，则可以使用字符串格式（如%s或｛field｝）。