这里是另一个不使用任何额外库的解决方案。

def delay_until(condition_fn, interval_in_sec, timeout_in_sec):
    """Delay using a boolean callable function.

    `condition_fn` is invoked every `interval_in_sec` until `timeout_in_sec`.
    It can break early if condition is met.

    Args:
        condition_fn     - a callable boolean function
        interval_in_sec  - wait time between calling `condition_fn`
        timeout_in_sec   - maximum time to run

    Returns: None
    """
    start = last_call = time.time()
    while time.time() - start < timeout_in_sec:
        if (time.time() - last_call) > interval_in_sec:
            if condition_fn() is True:
                break
            last_call = time.time()

我用这个方法使每小时产生60个事件，其中大多数事件在整分钟后的相同秒数内发生:

import math
import time
import random

TICK = 60 # one minute tick size
TICK_TIMING = 59 # execute on 59th second of the tick
TICK_MINIMUM = 30 # minimum catch up tick size when lagging

def set_timing():

    now = time.time()
    elapsed = now - info['begin']
    minutes = math.floor(elapsed/TICK)
    tick_elapsed = now - info['completion_time']
    if (info['tick']+1) > minutes:
        wait = max(0,(TICK_TIMING-(time.time() % TICK)))
        print ('standard wait: %.2f' % wait)
        time.sleep(wait)
    elif tick_elapsed < TICK_MINIMUM:
        wait = TICK_MINIMUM-tick_elapsed
        print ('minimum wait: %.2f' % wait)
        time.sleep(wait)
    else:
        print ('skip set_timing(); no wait')
    drift = ((time.time() - info['begin']) - info['tick']*TICK -
        TICK_TIMING + info['begin']%TICK)
    print ('drift: %.6f' % drift)

info['tick'] = 0
info['begin'] = time.time()
info['completion_time'] = info['begin'] - TICK

while 1:

    set_timing()

    print('hello world')

    #random real world event
    time.sleep(random.random()*TICK_MINIMUM)

    info['tick'] += 1
    info['completion_time'] = time.time()

根据实际情况，你可能会得到长度的刻度:

60,60,62,58,60,60,120,30,30,60,60,60,60,60...etc.

但在60分钟结束时，你会有60个滴答;而且它们中的大多数都将出现在您喜欢的正确偏移时间。

在我的系统中，我得到了< 1/20秒的典型漂移，直到需要纠正。

该方法的优点是具有较好的时钟漂移分辨率;这可能会导致问题，如果你做的事情，比如每tick追加一个项目，你希望每小时追加60个项目。未能考虑漂移可能导致次要指标，如移动平均线，将数据考虑得过于深入过去，从而导致错误的输出。

我以前也遇到过类似的问题。也许http://cronus.readthedocs.org会有帮助?

对于v0.2，下面的代码片段可以工作

import cronus.beat as beat

beat.set_rate(2) # run twice per second
while beat.true():
    # do some time consuming work here
    beat.sleep() # total loop duration would be 0.5 sec

你可能会考虑Twisted，它是一个实现了Reactor Pattern的Python网络库。

from twisted.internet import task, reactor

timeout = 60.0 # Sixty seconds

def doWork():
    #do work here
    pass

l = task.LoopingCall(doWork)
l.start(timeout) # call every sixty seconds

reactor.run()

虽然“While True: sleep(60)”可能会工作，Twisted可能已经实现了许多你最终需要的功能(如bobince指出的守护进程化、日志记录或异常处理)，并且可能是一个更健壮的解决方案

如果您的程序还没有事件循环，请使用sched模块，它实现了一个通用的事件调度器。

import sched, time

def do_something(scheduler): 
    # schedule the next call first
    scheduler.enter(60, 1, do_something, (scheduler,))
    print("Doing stuff...")
    # then do your stuff

my_scheduler = sched.scheduler(time.time, time.sleep)
my_scheduler.enter(60, 1, do_something, (my_scheduler,))
my_scheduler.run()

如果您已经在使用事件循环库，如asyncio、trio、tkinter、PyQt5、gobject、kivy等，则只需使用现有事件循环库的方法来调度任务。

另一种灵活性解决方案是Apscheduler。

pip install apscheduler

from apscheduler.schedulers.background import BlockingScheduler
def print_t():
  pass

sched = BlockingScheduler()
sched.add_job(print_t, 'interval', seconds =60) #will do the print_t work for every 60 seconds

sched.start()

另外，apscheduler提供了如下所示的许多调度程序。

BlockingScheduler: use when the scheduler is the only thing running in your process BackgroundScheduler: use when you’re not using any of the frameworks below, and want the scheduler to run in the background inside your application AsyncIOScheduler: use if your application uses the asyncio module GeventScheduler: use if your application uses gevent TornadoScheduler: use if you’re building a Tornado application TwistedScheduler: use if you’re building a Twisted application QtScheduler: use if you’re building a Qt application