这里有一个很容易概括或转化为函数的答案，它合理紧凑，易于遵循。

ts_start=datetime(2020, 12, 1, 3, 9, 45)
ts_end=datetime.now()
ts_diff=ts_end-ts_start
secs=ts_diff.total_seconds()
days,secs=divmod(secs,secs_per_day:=60*60*24)
hrs,secs=divmod(secs,secs_per_hr:=60*60)
mins,secs=divmod(secs,secs_per_min:=60)
secs=round(secs, 2)
answer='Duration={} days, {} hrs, {} mins and {} secs'.format(int(days),int(hrs),int(mins),secs)
print(answer)

它给出的答案是“持续时间=270天10小时32分42.13秒”

这是我使用mktime的方法。

from datetime import datetime, timedelta
from time import mktime

yesterday = datetime.now() - timedelta(days=1)
today = datetime.now()

difference_in_seconds = abs(mktime(yesterday.timetuple()) - mktime(today.timetuple()))
difference_in_minutes = difference_in_seconds / 60

这可能会帮助一些人，用这个方法找到过期与否其计算天数。这是dt。秒和dt。微秒也可用

from datetime import datetime
# updated_at = "2022-10-20T07:18:56.950563"
def is_expired(updated_at):
    expires_in = 7 #days
    datetime_format = '%Y-%m-%dT%H:%M:%S.%f'
    time_difference = datetime.now() - datetime.strptime(updated_at, datetime_format)

    return True if time_difference.days > expires_in else False

要得到小时、分和秒，你可以这样做

>>> import datetime
>>> first_time = datetime.datetime.now()
>>> later_time = datetime.datetime.now()
>>> difference = later_time - first_time
>>> m, s = divmod(difference.total_seconds(), 60)
>>> print("H:M:S is {}:{}:{}".format(m//60, m%60, s))

如果a, b是datetime对象，那么在Python 3中查找它们之间的时间差:

from datetime import timedelta

time_difference = a - b
time_difference_in_minutes = time_difference / timedelta(minutes=1)

在早期的Python版本中:

time_difference_in_minutes = time_difference.total_seconds() / 60

如果a, b是天真的datetime对象，例如datetime.now()返回的，那么如果对象表示具有不同UTC偏移量的本地时间，例如DST转换前后或过去/未来日期，则结果可能是错误的。更多细节:查找datetimes之间是否已经过了24小时- Python。

要获得可靠的结果，请使用UTC时间或时区感知的datetime对象。

只要用一个减去另一个。你会得到一个timedelta对象。

>>> import datetime
>>> d1 = datetime.datetime.now()
>>> d2 = datetime.datetime.now() # after a 5-second or so pause
>>> d2 - d1
datetime.timedelta(0, 5, 203000)
>>> dd = d2 - d1
>>> print (dd.days) # get days
>>> print (dd.seconds) # get seconds
>>> print (dd.microseconds) # get microseconds
>>> print (int(round(dd.total_seconds()/60, 0))) # get minutes