<TextBox AcceptsReturn="True" 
           TextWrapping="Wrap"  
           VerticalContentAlignment="Top" >
  </TextBox>

虽然Orion Edwards Answer适用于任何情况，但每次想要这样做时，添加边界和设置边界的属性可能是一件痛苦的事情。另一个快速的方法是设置文本块的填充:

<TextBlock Height="22" Padding="3" />

TextBlock不支持垂直文本对齐。

我通过用网格包装文本块并设置horizontalalign ="Stretch"和verticalalign ="Center"来解决这个问题。

是这样的:

<Grid>
    <TextBlock 
        HorizontalAlignment="Stretch"
        VerticalAlignment="Center"
        Text="Your text" />
</Grid>

一个文本块本身不能做垂直对齐

最好的方法，这样做，我发现是把文本块内的边界，所以边界为您对齐。

<Border BorderBrush="{x:Null}" Height="50">
    <TextBlock TextWrapping="Wrap" Text="Some Text" VerticalAlignment="Center"/>
</Border>

注意:这在功能上等同于使用网格，它只是取决于你想让控件如何与你的布局的其余部分相适应，以确定哪个更适合

我认为最好是使用一个标签(或TextBlock)变成一个标签，你不能直接在边界控件中附加鼠标事件，最后它附加在TextBlock中，这是我的建议:

<Label 
    Height="32"
    VerticalContentAlignment="Center"
    HorizontalContentAlignment="Stretch"
    MouseLeftButtonUp="MenuItem_MouseLeftButtonUp">
    <TextBlock Padding="32 0 10 0">
        Label with click event
    </TextBlock>
</Label>

To expand on the answer provided by @Orion Edwards, this is how you would do fully from code-behind (no styles set). Basically create a custom class that inherits from Border which has its Child set to a TextBox. The example below assumes that you only want a single line and that the border is a child of a Canvas. Also assumes you would need to adjust the MaxLength property of the TextBox based on the width of the Border. The example below also sets the cursor of the Border to mimic a Textbox by setting it to the type 'IBeam'. A margin of '3' is set so that the TextBox isn't absolutely aligned to the left of the border.

double __dX = 20;
double __dY = 180;
double __dW = 500;
double __dH = 40;
int __iMaxLen = 100;

this.m_Z3r0_TextBox_Description = new CZ3r0_TextBox(__dX, __dY, __dW, __dH, __iMaxLen, TextAlignment.Left);
this.Children.Add(this.m_Z3r0_TextBox_Description);

类:

using System;
using System.Collections.Generic;
using System.Text;
using System.Windows;
using System.Windows.Controls;
using System.Windows.Input;
using System.Windows.Media;
using System.Windows.Shapes;
using System.Windows.Controls.Primitives;


namespace ifn0tz3r0Exp
{
    class CZ3r0_TextBox : Border
    {
        private TextBox m_TextBox;

        private SolidColorBrush m_Brush_Green = new SolidColorBrush(Colors.MediumSpringGreen);
        private SolidColorBrush m_Brush_Black = new SolidColorBrush(Colors.Black);
        private SolidColorBrush m_Brush_Transparent = new SolidColorBrush(Colors.Transparent);

        public CZ3r0_TextBox(double _dX, double _dY, double _dW, double _dH, int _iMaxLen, TextAlignment _Align)
        {

            /////////////////////////////////////////////////////////////
            //TEXTBOX
            this.m_TextBox = new TextBox();
            this.m_TextBox.Text = "This is a vertically centered one-line textbox embedded in a border...";
            Canvas.SetLeft(this, _dX);
            Canvas.SetTop(this, _dY);
            this.m_TextBox.FontFamily = new FontFamily("Consolas");
            this.m_TextBox.FontSize = 11;
            this.m_TextBox.Background = this.m_Brush_Black;
            this.m_TextBox.Foreground = this.m_Brush_Green;
            this.m_TextBox.BorderBrush = this.m_Brush_Transparent;
            this.m_TextBox.BorderThickness = new Thickness(0.0);
            this.m_TextBox.Width = _dW;
            this.m_TextBox.MaxLength = _iMaxLen;
            this.m_TextBox.TextAlignment = _Align;
            this.m_TextBox.VerticalAlignment = System.Windows.VerticalAlignment.Center;
            this.m_TextBox.FocusVisualStyle = null;
            this.m_TextBox.Margin = new Thickness(3.0);
            this.m_TextBox.CaretBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionBrush = this.m_Brush_Green;
            this.m_TextBox.SelectionOpacity = 0.3;

            this.m_TextBox.GotFocus += this.CZ3r0_TextBox_GotFocus;
            this.m_TextBox.LostFocus += this.CZ3r0_TextBox_LostFocus;
            /////////////////////////////////////////////////////////////
            //BORDER

            this.BorderBrush = this.m_Brush_Transparent;
            this.BorderThickness = new Thickness(1.0);
            this.Background = this.m_Brush_Black;            
            this.Height = _dH;
            this.Child = this.m_TextBox;
            this.FocusVisualStyle = null;
            this.MouseDown += this.CZ3r0_TextBox_MouseDown;
            this.Cursor = Cursors.IBeam;
            /////////////////////////////////////////////////////////////
        }
        private void CZ3r0_TextBox_MouseDown(object _Sender, MouseEventArgs e)
        {
            this.m_TextBox.Focus();
        }
        private void CZ3r0_TextBox_GotFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Green;
        }
        private void CZ3r0_TextBox_LostFocus(object _Sender, RoutedEventArgs e)
        {
            this.BorderBrush = this.m_Brush_Transparent;
        }
    }
}