这可能是一个很晚的回复，但使用setCancelable就可以了。

alertDial.setCancelable(false);

对于API 8之前的版本，如果editText的内容不正确，我使用一个布尔标志、一个关闭监听器并再次调用dialog.show来解决这个问题。这样地：

case ADD_CLIENT:
        LayoutInflater factoryClient = LayoutInflater.from(this);
        final View EntryViewClient = factoryClient.inflate(
                R.layout.alert_dialog_add_client, null);

        EditText ClientText = (EditText) EntryViewClient
                .findViewById(R.id.client_edit);

        AlertDialog.Builder builderClient = new AlertDialog.Builder(this);
        builderClient
                .setTitle(R.string.alert_dialog_client)
                .setCancelable(false)
                .setView(EntryViewClient)
                .setPositiveButton("Save",
                        new DialogInterface.OnClickListener() {
                            public void onClick(DialogInterface dialog,
                                    int whichButton) {
                                EditText newClient = (EditText) EntryViewClient
                                        .findViewById(R.id.client_edit);
                                String newClientString = newClient
                                        .getText().toString();
                                if (checkForEmptyFields(newClientString)) {
                                    //If field is empty show toast and set error flag to true;
                                    Toast.makeText(getApplicationContext(),
                                            "Fields cant be empty",
                                            Toast.LENGTH_SHORT).show();
                                    add_client_error = true;
                                } else {
                                    //Here save the info and set the error flag to false
                                    add_client_error = false;
                                }
                            }
                        })
                .setNegativeButton("Cancel",
                        new DialogInterface.OnClickListener() {
                            public void onClick(DialogInterface dialog,
                                    int id) {
                                add_client_error = false;
                                dialog.cancel();
                            }
                        });
        final AlertDialog alertClient = builderClient.create();
        alertClient.show();

        alertClient
                .setOnDismissListener(new DialogInterface.OnDismissListener() {

                    @Override
                    public void onDismiss(DialogInterface dialog) {
                        //If the error flag was set to true then show the dialog again
                        if (add_client_error == true) {
                            alertClient.show();
                        } else {
                            return;
                        }

                    }
                });
        return true;

对于ProgressDialogs

要防止对话框自动关闭，必须在显示ProgressDialog后设置OnClickListener，如下所示：

connectingDialog = new ProgressDialog(this);

connectingDialog.setCancelable(false);
connectingDialog.setCanceledOnTouchOutside(false);

// Create the button but set the listener to a null object.
connectingDialog.setButton(DialogInterface.BUTTON_NEGATIVE, "Cancel", 
        (DialogInterface.OnClickListener) null )

// Show the dialog so we can then get the button from the view.
connectingDialog.show();

// Get the button from the view.
Button dialogButton = connectingDialog.getButton( DialogInterface.BUTTON_NEGATIVE);

// Set the onClickListener here, in the view.
dialogButton.setOnClickListener( new View.OnClickListener() {

    @Override
    public void onClick ( View v ) {

        // Dialog will not get dismissed until you call dismiss() explicitly.

    }

});

编辑：这只适用于一些评论中提到的API 8+。

这是一个迟到的回答，但您可以在AlertDialog中添加一个onShowListener，然后可以覆盖按钮的onClickListener。

final AlertDialog dialog = new AlertDialog.Builder(context)
        .setView(v)
        .setTitle(R.string.my_title)
        .setPositiveButton(android.R.string.ok, null) //Set to null. We override the onclick
        .setNegativeButton(android.R.string.cancel, null)
        .create();

dialog.setOnShowListener(new DialogInterface.OnShowListener() {

    @Override
    public void onShow(DialogInterface dialogInterface) {

        Button button = ((AlertDialog) dialog).getButton(AlertDialog.BUTTON_POSITIVE);
        button.setOnClickListener(new View.OnClickListener() {

            @Override
            public void onClick(View view) {
                // TODO Do something

                //Dismiss once everything is OK.
                dialog.dismiss();
            }
        });
    }
});
dialog.show();

受汤姆的回答启发，我认为这里的想法是：

在创建对话框期间将onClickListener设置为null然后在显示对话框后设置onClickListener。

您可以像Tom一样重写onShowListener。或者，您可以

调用AlertDialog的show（）后获取按钮按如下方式设置按钮的onClickListener（我认为稍微可读一些）。

代码：

AlertDialog.Builder builder = new AlertDialog.Builder(context);
// ...
final AlertDialog dialog = builder.create();
dialog.show();
// now you can override the default onClickListener
Button b = dialog.getButton(AlertDialog.BUTTON_POSITIVE);
b.setOnClickListener(new View.OnClickListener() {
    @Override
    public void onClick(View view) {
        Log.i(TAG, "ok button is clicked");
        handleClick(dialog);
    }
});

为DialogFragment使用自定义布局，并在内容下添加LinearLayout，该布局可以设置为无边框，以匹配Google Material Design。然后找到新创建的按钮并覆盖其OnClickListener。

例子：

public class AddTopicFragment extends DialogFragment {

    @Override
    public Dialog onCreateDialog(Bundle savedInstanceState) {
        final AlertDialog.Builder builder = new AlertDialog.Builder(getActivity());
        // Get the layout inflater
        LayoutInflater inflater = getActivity().getLayoutInflater();
        final View dialogView = inflater.inflate(R.layout.dialog_add_topic, null);

        Button saveTopicDialogButton = (Button) dialogView.findViewById(R.id.saveTopicDialogButton);
        Button cancelSaveTopicDialogButton = (Button) dialogView.findViewById(R.id.cancelSaveTopicDialogButton);

        final AppCompatEditText addTopicNameET = (AppCompatEditText) dialogView.findViewById(R.id.addTopicNameET);
        final AppCompatEditText addTopicCreatedByET = (AppCompatEditText) dialogView.findViewById(R.id.addTopicCreatedByET);

        saveTopicDialogButton.setOnClickListener(new View.OnClickListener() {
            @Override
            public void onClick(View v) {
                // validate inputs
                if(addTopicNameET.getText().toString().trim().isEmpty()){
                    addTopicNameET.setError("Topic name can't be empty");
                    addTopicNameET.requestFocus();
                }else if(addTopicCreatedByET.getText().toString().trim().isEmpty()){
                    addTopicCreatedByET.setError("Topic created by can't be empty");
                    addTopicCreatedByET.requestFocus();
                }else {
                    // save topic to database
                    Topic topic = new Topic();
                    topic.name = addTopicNameET.getText().toString().trim();
                    topic.createdBy = addTopicCreatedByET.getText().toString().trim();
                    topic.createdDate = new Date().getTime();
                    topic.save();
                    AddTopicFragment.this.dismiss();
                }
            }
        });

        cancelSaveTopicDialogButton.setOnClickListener(new View.OnClickListener() {
            @Override
            public void onClick(View v) {
                AddTopicFragment.this.dismiss();
            }
        });

        // Inflate and set the layout for the dialog
        // Pass null as the parent view because its going in the dialog layout
        builder.setView(dialogView)
               .setMessage(getString(R.string.add_topic_message));

        return builder.create();
    }

}

dialog_add_topic.xml：

<?xml version="1.0" encoding="utf-8"?>
<LinearLayout xmlns:android="http://schemas.android.com/apk/res/android"
    xmlns:app="http://schemas.android.com/apk/res-auto"
    android:orientation="vertical"
    android:padding="@dimen/activity_horizontal_margin"
    android:layout_width="match_parent"
    android:layout_height="match_parent">

    <android.support.design.widget.TextInputLayout
        android:layout_width="match_parent"
        android:layout_height="wrap_content"
        app:errorEnabled="true">

        <android.support.v7.widget.AppCompatEditText
            android:id="@+id/addTopicNameET"
            android:layout_width="match_parent"
            android:layout_height="wrap_content"
            android:hint="Topic Name"
            android:inputType="textPersonName"
            android:maxLines="1" />

    </android.support.design.widget.TextInputLayout>

    <android.support.design.widget.TextInputLayout
        android:layout_width="match_parent"
        android:layout_height="wrap_content"
        app:errorEnabled="true">

        <android.support.v7.widget.AppCompatEditText
            android:id="@+id/addTopicCreatedByET"
            android:layout_width="match_parent"
            android:layout_height="wrap_content"
            android:hint="Created By"
            android:inputType="textPersonName"
            android:maxLines="1" />

    </android.support.design.widget.TextInputLayout>

    <LinearLayout
        android:layout_width="match_parent"
        android:layout_height="wrap_content"
        android:orientation="horizontal">
        <Button
            android:text="@string/cancel"
            android:layout_weight="1"
            android:layout_width="match_parent"
            android:layout_height="wrap_content"
            android:id="@+id/cancelSaveTopicDialogButton"
            style="@style/Widget.AppCompat.Button.ButtonBar.AlertDialog" />

        <Button
            android:text="@string/save"
            android:layout_weight="1"
            android:layout_width="match_parent"
            android:layout_height="wrap_content"
            android:id="@+id/saveTopicDialogButton"
            style="@style/Widget.AppCompat.Button.ButtonBar.AlertDialog" />

    </LinearLayout>


</LinearLayout>

这是最终结果。