发送到自定义页面:

app.get('*', function(req, res){
  if (req.accepts('html')) {
     res.send('404', '<script>location.href = "/the-404-page.html";</script>');
     return;
  }
});

// Add this middleware
// error handler
app.use(function(err, req, res, next) {
 // set locals, only providing error in development
   res.locals.message = err.message;
   res.locals.error = req.app.get('env') === 'development' ? err : {};

 // render the error page
   res.status(err.status || 500);
   res.render('error');
  });

我认为你应该首先定义你所有的路线，然后作为最后的路线添加

//The 404 Route (ALWAYS Keep this as the last route)
app.get('*', function(req, res){
  res.status(404).send('what???');
});

一个示例应用程序的工作:

app.js:

var express = require('express'),
    app = express.createServer();

app.use(express.static(__dirname + '/public'));

app.get('/', function(req, res){
  res.send('hello world');
});

//The 404 Route (ALWAYS Keep this as the last route)
app.get('*', function(req, res){
  res.send('what???', 404);
});

app.listen(3000, '127.0.0.1');

alfred@alfred-laptop:~/node/stackoverflow/6528876$ mkdir public
alfred@alfred-laptop:~/node/stackoverflow/6528876$ find .
alfred@alfred-laptop:~/node/stackoverflow/6528876$ echo "I don't find a function for that... Anyone knows?" > public/README.txt
alfred@alfred-laptop:~/node/stackoverflow/6528876$ cat public/README.txt 

.
./app.js
./public
./public/README.txt

alfred@alfred-laptop:~/node/stackoverflow/6528876$ curl http://localhost:3000/
hello world
alfred@alfred-laptop:~/node/stackoverflow/6528876$ curl http://localhost:3000/README.txt
I don't find a function for that... Anyone knows?

在某些情况下，404页面不能被写入并作为最后一个路由执行，特别是如果您有一个异步路由功能，从而引入了一个迟到的/路由。在这些情况下可以采用下面的模式。

var express = require("express.io"),
    app = express(),
    router = express.Router();

router.get("/hello", function (req, res) {
    res.send("Hello World");
});

// Router is up here.
app.use(router);

app.use(function(req, res) {
    res.send("Crime Scene 404. Do not repeat");
});

router.get("/late", function (req, res) {
    res.send("Its OK to come late");
});

app.listen(8080, function (){
    console.log("Ready");
});

这种方法更简单，但它必须是所有路线之后的最后一件事。

app.use( (req, res) => {
    //render page not found 
    res.render('404')
})

发送到自定义页面:

app.get('*', function(req, res){
  if (req.accepts('html')) {
     res.send('404', '<script>location.href = "/the-404-page.html";</script>');
     return;
  }
});