从Swift 1.0开始，对我来说有用的是检查除了arm之外的架构:

#if arch(i386) || arch(x86_64)

     //simulator
#else 
     //device

#endif

斯威夫特4

现在可以使用targetEnvironment(模拟器)作为参数。

#if targetEnvironment(simulator)
    // Simulator
#else
    // Device
#endif

为Xcode 9.3更新

运行时，但比这里的大多数其他解决方案更简单:

if TARGET_OS_SIMULATOR != 0 {
    // target is current running in the simulator
}

或者，你可以调用一个Objective-C helper函数来返回一个使用预处理器宏的布尔值(特别是如果你已经在你的项目中混合了)。

编辑:不是最好的解决方案，特别是在Xcode 9.3中。请看HotJard的回答

Xcode 11, Swift 5

    #if !targetEnvironment(macCatalyst)
    #if targetEnvironment(simulator)
        true
    #else
        false        
    #endif
    #endif

来自Xcode 9.3

#if targetEnvironment(simulator)

Swift supports a new platform condition targetEnvironment with a single valid argument simulator. Conditional compilation of the form '#if targetEnvironment(simulator)' can now be used to detect when the build target is a simulator. The Swift compiler will attempt to detect, warn, and suggest the use of targetEnvironment(simulator) when evaluating platform conditions that appear to be testing for simulator environments indirectly, via the existing os() and arch() platform conditions. (SE-0190)

iOS 9+：

extension UIDevice {
    static var isSimulator: Bool {
        return NSProcessInfo.processInfo().environment["SIMULATOR_DEVICE_NAME"] != nil
    }
}

斯威夫特3:

extension UIDevice {
    static var isSimulator: Bool {
        return ProcessInfo.processInfo.environment["SIMULATOR_DEVICE_NAME"] != nil
    }
}

iOS 9之前:

extension UIDevice {
    static var isSimulator: Bool {
        return UIDevice.currentDevice().model == "iPhone Simulator"
    }
}

objective - c:

@interface UIDevice (Additions)
- (BOOL)isSimulator;
@end

@implementation UIDevice (Additions)

- (BOOL)isSimulator {
    if([[NSProcessInfo processInfo] isOperatingSystemAtLeastVersion:(NSOperatingSystemVersion){9, 0, 0}]) {
        return [NSProcessInfo processInfo].environment[@"SIMULATOR_DEVICE_NAME"] != nil;
    } else {
        return [[self model] isEqualToString:@"iPhone Simulator"];
    }
}

@end

除了其他答案。

在Objective-c中，确保你包含了TargetConditionals。

# include < TargetConditionals.h >

在使用TARGET_OS_SIMULATOR之前。