如果你使用Node.js，你可以这样做:

let a = Buffer.from('JavaScript').toString('base64');
console.log(a);

let b = Buffer.from(a, 'base64').toString();
console.log(b);

为了使Base64编码的字符串URL友好，在JavaScript中你可以这样做:

// if this is your Base64 encoded string
var str = 'VGhpcyBpcyBhbiBhd2Vzb21lIHNjcmlwdA=='; 

// make URL friendly:
str = str.replace(/\+/g, '-').replace(/\//g, '_').replace(/\=+$/, '');

// reverse to original encoding
str = (str + '===').slice(0, str.length + (str.length % 4));
str = str.replace(/-/g, '+').replace(/_/g, '/');

参见这个小提琴:http://jsfiddle.net/magikMaker/7bjaT/

请注意，这不适用于原始的Unicode字符串!请参阅这里的Unicode部分。

编码语法

var encodedData = window.btoa（stringToEncode）;

解码语法

var decodedData = window.atob（encodedData）;

从这里开始:

/**
*
*  Base64 encode / decode
*  http://www.webtoolkit.info/
*
**/
var Base64 = {

    // private property
    _keyStr : "ABCDEFGHIJKLMNOPQRSTUVWXYZabcdefghijklmnopqrstuvwxyz0123456789+/=",

    // public method for encoding
    encode : function (input) {
        var output = "";
        var chr1, chr2, chr3, enc1, enc2, enc3, enc4;
        var i = 0;

        input = Base64._utf8_encode(input);

        while (i < input.length) {

            chr1 = input.charCodeAt(i++);
            chr2 = input.charCodeAt(i++);
            chr3 = input.charCodeAt(i++);

            enc1 = chr1 >> 2;
            enc2 = ((chr1 & 3) << 4) | (chr2 >> 4);
            enc3 = ((chr2 & 15) << 2) | (chr3 >> 6);
            enc4 = chr3 & 63;

            if (isNaN(chr2)) {
                enc3 = enc4 = 64;
            } else if (isNaN(chr3)) {
                enc4 = 64;
            }

            output = output +
            this._keyStr.charAt(enc1) + this._keyStr.charAt(enc2) +
            this._keyStr.charAt(enc3) + this._keyStr.charAt(enc4);
        }
        return output;
    },

    // public method for decoding
    decode : function (input) {
        var output = "";
        var chr1, chr2, chr3;
        var enc1, enc2, enc3, enc4;
        var i = 0;

        input = input.replace(/[^A-Za-z0-9\+\/\=]/g, "");

        while (i < input.length) {

            enc1 = this._keyStr.indexOf(input.charAt(i++));
            enc2 = this._keyStr.indexOf(input.charAt(i++));
            enc3 = this._keyStr.indexOf(input.charAt(i++));
            enc4 = this._keyStr.indexOf(input.charAt(i++));

            chr1 = (enc1 << 2) | (enc2 >> 4);
            chr2 = ((enc2 & 15) << 4) | (enc3 >> 2);
            chr3 = ((enc3 & 3) << 6) | enc4;

            output = output + String.fromCharCode(chr1);

            if (enc3 != 64) {
                output = output + String.fromCharCode(chr2);
            }
            if (enc4 != 64) {
                output = output + String.fromCharCode(chr3);
            }
        }

        output = Base64._utf8_decode(output);

        return output;
    },

    // private method for UTF-8 encoding
    _utf8_encode : function (string) {
        string = string.replace(/\r\n/g,"\n");
        var utftext = "";

        for (var n = 0; n < string.length; n++) {

            var c = string.charCodeAt(n);

            if (c < 128) {
                utftext += String.fromCharCode(c);
            }
            else if((c > 127) && (c < 2048)) {
                utftext += String.fromCharCode((c >> 6) | 192);
                utftext += String.fromCharCode((c & 63) | 128);
            }
            else {
                utftext += String.fromCharCode((c >> 12) | 224);
                utftext += String.fromCharCode(((c >> 6) & 63) | 128);
                utftext += String.fromCharCode((c & 63) | 128);
            }
        }
        return utftext;
    },

    // private method for UTF-8 decoding
    _utf8_decode : function (utftext) {
        var string = "";
        var i = 0;
        var c = c1 = c2 = 0;

        while ( i < utftext.length ) {

            c = utftext.charCodeAt(i);

            if (c < 128) {
                string += String.fromCharCode(c);
                i++;
            }
            else if((c > 191) && (c < 224)) {
                c2 = utftext.charCodeAt(i+1);
                string += String.fromCharCode(((c & 31) << 6) | (c2 & 63));
                i += 2;
            }
            else {
                c2 = utftext.charCodeAt(i+1);
                c3 = utftext.charCodeAt(i+2);
                string += String.fromCharCode(((c & 15) << 12) | ((c2 & 63) << 6) | (c3 & 63));
                i += 3;
            }
        }
        return string;
    }
}

此外，搜索“JavaScript base64 encoding”会出现许多其他选项，上面是第一个。

对于更新的浏览器编码Uint8Array到字符串，并解码字符串到Uint8Array。

const base64 = {
    decode: s => Uint8Array.from(atob(s), c => c.charCodeAt(0)),
    encode: b => btoa(String.fromCharCode(...new Uint8Array(b)))
};

对于Node.js，你可以使用以下代码将string、Buffer或Uint8Array编码为string，并从string、Buffer或Uint8Array解码为Buffer。

const base64 = {
    decode: s => Buffer.from(s, 'base64'),
    encode: b => Buffer.from(b).toString('base64')
};

这里的所有解决方案在某些情况下似乎都失败了，而且理解起来相当复杂。 特别是对于非拉丁语言，如阿拉伯语

这里有一个解码UTF-16的简短解决方案

//decodes utf-16 characters such as ARABIC, URDU,PASHTO text
function decodeBase64(s) {
    var percentEncodedStr = atob(s).split('').map(function (c) {
        return '%' + ('00' + c.charCodeAt(0).toString(16)).slice(-2);
    }).join('');
    return decodeURIComponent(percentEncodedStr);
}