PatrickDesjardins的回答看起来不错，但我更喜欢简单的JavaScript代码。下面是我刚刚编写的一个函数，用于输入一个数字并以货币格式返回（减去美元符号）：

// Format numbers to two decimals with commas
function formatDollar(num) {
    var p = num.toFixed(2).split(".");
    var chars = p[0].split("").reverse();
    var newstr = '';
    var count = 0;
    for (x in chars) {
        count++;
        if(count%3 == 1 && count != 1) {
            newstr = chars[x] + ',' + newstr;
        } else {
            newstr = chars[x] + newstr;
        }
    }
    return newstr + "." + p[1];
}

YUI代码库使用以下格式：

format: function(nData, oConfig) {
    oConfig = oConfig || {};

    if(!YAHOO.lang.isNumber(nData)) {
        nData *= 1;
    }

    if(YAHOO.lang.isNumber(nData)) {
        var sOutput = nData + "";
        var sDecimalSeparator = (oConfig.decimalSeparator) ? oConfig.decimalSeparator : ".";
        var nDotIndex;

        // Manage decimals
        if(YAHOO.lang.isNumber(oConfig.decimalPlaces)) {
            // Round to the correct decimal place
            var nDecimalPlaces = oConfig.decimalPlaces;
            var nDecimal = Math.pow(10, nDecimalPlaces);
            sOutput = Math.round(nData*nDecimal)/nDecimal + "";
            nDotIndex = sOutput.lastIndexOf(".");

            if(nDecimalPlaces > 0) {
                // Add the decimal separator
                if(nDotIndex < 0) {
                    sOutput += sDecimalSeparator;
                    nDotIndex = sOutput.length-1;
                }
                // Replace the "."
                else if(sDecimalSeparator !== "."){
                    sOutput = sOutput.replace(".",sDecimalSeparator);
                }
                // Add missing zeros
                while((sOutput.length - 1 - nDotIndex) < nDecimalPlaces) {
                    sOutput += "0";
                }
            }
        }

        // Add the thousands separator
        if(oConfig.thousandsSeparator) {
            var sThousandsSeparator = oConfig.thousandsSeparator;
            nDotIndex = sOutput.lastIndexOf(sDecimalSeparator);
            nDotIndex = (nDotIndex > -1) ? nDotIndex : sOutput.length;
            var sNewOutput = sOutput.substring(nDotIndex);
            var nCount = -1;
            for (var i=nDotIndex; i>0; i--) {
                nCount++;
                if ((nCount%3 === 0) && (i !== nDotIndex)) {
                    sNewOutput = sThousandsSeparator + sNewOutput;
                }
                sNewOutput = sOutput.charAt(i-1) + sNewOutput;
            }
            sOutput = sNewOutput;
        }

        // Prepend prefix
        sOutput = (oConfig.prefix) ? oConfig.prefix + sOutput : sOutput;

        // Append suffix
        sOutput = (oConfig.suffix) ? sOutput + oConfig.suffix : sOutput;

        return sOutput;
    }
    // Still not a number. Just return it unaltered
    else {
        return nData;
    }
}

它需要编辑，因为YUI库是可配置的，比如用“.”替换oConfig.decimalSeparator。

我主要基于VisionN的回答：

function format (val) {
  val = (+val).toLocaleString();
  val = (+val).toFixed(2);
  val += "";
  return val.replace(/(\d)(?=(\d{3})+(?:\.\d+)?$)/g, "$1" + format.thousands);
}

(function (isUS) {
  format.decimal =   isUS ? "." : ",";
  format.thousands = isUS ? "," : ".";
}(("" + (+(0.00).toLocaleString()).toFixed(2)).indexOf(".") > 0));

我用输入进行了测试：

[   ""
  , "1"
  , "12"
  , "123"
  , "1234"
  , "12345"
  , "123456"
  , "1234567"
  , "12345678"
  , "123456789"
  , "1234567890"
  , ".12"
  , "1.12"
  , "12.12"
  , "123.12"
  , "1234.12"
  , "12345.12"
  , "123456.12"
  , "1234567.12"
  , "12345678.12"
  , "123456789.12"
  , "1234567890.12"
  , "1234567890.123"
  , "1234567890.125"
].forEach(function (item) {
  console.log(format(item));
});

得到了这些结果：

0.00
1.00
12.00
123.00
1,234.00
12,345.00
123,456.00
1,234,567.00
12,345,678.00
123,456,789.00
1,234,567,890.00
0.12
1.12
12.12
123.12
1,234.12
12,345.12
123,456.12
1,234,567.12
12,345,678.12
123,456,789.12
1,234,567,890.12
1,234,567,890.12
1,234,567,890.13

只是为了好玩。

这可能有点晚了，但这是我刚刚为同事准备的一个方法，可以为所有数字添加一个支持区域设置的.toCurrencyString（）函数。内部化仅用于数字分组，而不是货币符号-如果您输出美元，请使用提供的“$”，因为日本或中国的123 4567美元与美国的1234567美元相同。如果您输出欧元等，请将货币符号从“$”改为“$”。

在HTML＜head＞部分的任何地方或在需要使用它之前的任何地方声明：

  Number.prototype.toCurrencyString = function(prefix, suffix) {
    if (typeof prefix === 'undefined') { prefix = '$'; }
    if (typeof suffix === 'undefined') { suffix = ''; }
    var _localeBug = new RegExp((1).toLocaleString().replace(/^1/, '').replace(/\./, '\\.') + "$");
    return prefix + (~~this).toLocaleString().replace(_localeBug, '') + (this % 1).toFixed(2).toLocaleString().replace(/^[+-]?0+/,'') + suffix;
  }

那你就完了！在需要将数字输出为货币的任何位置使用（number）.toCurrencyString（）。

var MyNumber = 123456789.125;
alert(MyNumber.toCurrencyString()); // alerts "$123,456,789.13"
MyNumber = -123.567;
alert(MyNumber.toCurrencyString()); // alerts "$-123.57"

另一种方式：

function centsToDollaString(x){
  var cents = x + ""
  while(cents.length < 4){
    cents = "0" + cents;
  }
  var dollars = cents.substr(0,cents.length - 2)
  var decimal = cents.substr(cents.length - 2, 2)
  while(dollars.length % 3 != 0){
    dollars = "0" + dollars;
  }
  str = dollars.replace(/(\d{3})(?=\d)/g, "$1" + ",").replace(/^0*(?=.)/, "");
  return "$" + str + "." + decimal;
}

乔纳森·M的代码对我来说太复杂了，所以我重写了它，在Firefox v30上获得了30%的速度提升，在Chrome v35上获得了60%的速度提升(http://jsperf.com/number-formating2):

Number.prototype.formatNumber = function(decPlaces, thouSeparator, decSeparator) {
    decPlaces = isNaN(decPlaces = Math.abs(decPlaces)) ? 2 : decPlaces;
    decSeparator = decSeparator == undefined ? "." : decSeparator;
    thouSeparator = thouSeparator == undefined ? "," : thouSeparator;

    var n = this.toFixed(decPlaces);
    if (decPlaces) {
        var i = n.substr(0, n.length - (decPlaces + 1));
        var j = decSeparator + n.substr(-decPlaces);
    } else {
        i = n;
        j = '';
    }

    function reverse(str) {
        var sr = '';
        for (var l = str.length - 1; l >= 0; l--) {
            sr += str.charAt(l);
        }
        return sr;
    }

    if (parseInt(i)) {
        i = reverse(reverse(i).replace(/(\d{3})(?=\d)/g, "$1" + thouSeparator));
    }
    return i + j;
};

用法：

var sum = 123456789.5698;
var formatted = '$' + sum.formatNumber(2, ',', '.'); // "$123,456,789.57"