一个简单的选项，通过先反转字符串和基本正则表达式来正确放置逗号。

String.prototype.reverse = function() {
    return this.split('').reverse().join('');
};

Number.prototype.toCurrency = function( round_decimal /*boolean*/ ) {       
     // format decimal or round to nearest integer
     var n = this.toFixed( round_decimal ? 0 : 2 );

     // convert to a string, add commas every 3 digits from left to right 
     // by reversing string
     return (n + '').reverse().replace( /(\d{3})(?=\d)/g, '$1,' ).reverse();
};

String.prototype.toPrice = function () {
    var v;
    if (/^\d+(,\d+)$/.test(this))
        v = this.replace(/,/, '.');
    else if (/^\d+((,\d{3})*(\.\d+)?)?$/.test(this))
        v = this.replace(/,/g, "");
    else if (/^\d+((.\d{3})*(,\d+)?)?$/.test(this))
        v = this.replace(/\./g, "").replace(/,/, ".");
    var x = parseFloat(v).toFixed(2).toString().split("."),
    x1 = x[0],
    x2 = ((x.length == 2) ? "." + x[1] : ".00"),
    exp = /^([0-9]+)(\d{3})/;
    while (exp.test(x1))
        x1 = x1.replace(exp, "$1" + "," + "$2");
    return x1 + x2;
}

alert("123123".toPrice()); //123,123.00
alert("123123,316".toPrice()); //123,123.32
alert("12,312,313.33213".toPrice()); //12,312,313.33
alert("123.312.321,32132".toPrice()); //123,312,321.32

这里有一个普通JavaScript的简单格式化程序：

function numberFormatter (num) {
    console.log(num)
    var wholeAndDecimal = String(num.toFixed(2)).split(".");
    console.log(wholeAndDecimal)
    var reversedWholeNumber = Array.from(wholeAndDecimal[0]).reverse();
    var formattedOutput = [];

    reversedWholeNumber.forEach( (digit, index) => {
        formattedOutput.push(digit);
        if ((index + 1) % 3 === 0 && index < reversedWholeNumber.length - 1) {
            formattedOutput.push(",");
        }
    })

    formattedOutput = formattedOutput.reverse().join('') + "." + wholeAndDecimal[1];

    return formattedOutput;
}

一种仅满足原始要求的极简方法：

function formatMoney(n) {
    return "$ " + (Math.round(n * 100) / 100).toLocaleString();
}

@丹尼尔·马格廖拉：你说得对。以上是一个仓促而不完整的实施。以下是正确的实施方式：

function formatMoney(n) {
    return "$ " + n.toLocaleString().split(".")[0] + "."
        + n.toFixed(2).split(".")[1];
}

此答案符合以下标准：

不依赖于外部依赖项。支持本地化。有测试/证明。使用简单和最佳的编码实践（没有复杂的正则表达式，使用标准的编码模式）。

此代码基于其他答案中的概念。如果这是一个问题的话，它的执行速度应该是最好的。

var decimalCharacter = Number("1.1").toLocaleString().substr(1,1);
var defaultCurrencyMarker = "$";
function formatCurrency(number, currencyMarker) {
    if (typeof number != "number")
        number = parseFloat(number, 10);

    // if NaN is passed in or comes from the parseFloat, set it to 0.
    if (isNaN(number))
        number = 0;

    var sign = number < 0 ? "-" : "";
    number = Math.abs(number);    // so our signage goes before the $ symbol.

    var integral = Math.floor(number);
    var formattedIntegral = integral.toLocaleString();

    // IE returns "##.00" while others return "##"
    formattedIntegral = formattedIntegral.split(decimalCharacter)[0];

    var decimal = Math.round((number - integral) * 100);
    return sign + (currencyMarker || defaultCurrencyMarker) +
        formattedIntegral  +
        decimalCharacter +
        decimal.toString() + (decimal < 10 ? "0" : "");
}

这些测试仅适用于美国语言环境机器。做出这个决定是为了简单，因为这可能会导致糟糕的输入（错误的自动定位），从而导致糟糕的输出问题。

var tests = [
    // [ input, expected result ]
    [123123, "$123,123.00"],    // no decimal
    [123123.123, "$123,123.12"],    // decimal rounded down
    [123123.126, "$123,123.13"],    // decimal rounded up
    [123123.4, "$123,123.40"],    // single decimal
    ["123123", "$123,123.00"],    // repeat subset of the above using string input.
    ["123123.123", "$123,123.12"],
    ["123123.126", "$123,123.13"],
    [-123, "-$123.00"]    // negatives
];

for (var testIndex=0; testIndex < tests.length; testIndex++) {
    var test = tests[testIndex];
    var formatted = formatCurrency(test[0]);
    if (formatted == test[1]) {
        console.log("Test passed, \"" + test[0] + "\" resulted in \"" + formatted + "\"");
    } else {
        console.error("Test failed. Expected \"" + test[1] + "\", got \"" + formatted + "\"");
    }
}

Intl.NumberFormat（国际数字格式）

var number = 3500;
alert(new Intl.NumberFormat().format(number));
// → "3,500" if in US English locale

或者JavaScript中的PHP的number_format。