一切都很好，但这也应该在env中工作:

PROCESSOR_ARCHITECTURE=x86

..

PROCESSOR_ARCHITECTURE=AMD64

可能太简单了;-)

这是一个基于微软http://1code.codeplex.com/SourceControl/changeset/view/39074#842775代码的解决方案。它使用扩展方法方便代码重用。

下面是一些可能的用法:

bool bIs64BitOS = System.Environment.OSVersion.IsWin64BitOS();

bool bIs64BitProc = System.Diagnostics.Process.GetCurrentProcess().Is64BitProc();

//Hosts the extension methods  
public static class OSHelperTools  
{  
    /// <summary>     
    /// The function determines whether the current operating system is a      
    /// 64-bit operating system.     
    /// </summary>     
    /// <returns>     
    /// The function returns true if the operating system is 64-bit;      
    /// otherwise, it returns false.     
    /// </returns>    
    public static bool IsWin64BitOS(this OperatingSystem os)  
    {  
        if (IntPtr.Size == 8)  
        // 64-bit programs run only on Win64           
            return true;   
        else// 32-bit programs run on both 32-bit and 64-bit Windows     
        {   // Detect whether the current process is a 32-bit process                
            // running on a 64-bit system.               
            return Process.GetCurrentProcess().Is64BitProc();  
        }  
    }  

    /// <summary>  
    /// Checks if the process is 64 bit  
    /// </summary>  
    /// <param name="os"></param>  
    /// <returns>  
    /// The function returns true if the process is 64-bit;        
    /// otherwise, it returns false.  
    /// </returns>    
    public static bool Is64BitProc(this System.Diagnostics.Process p)  
    {  
        // 32-bit programs run on both 32-bit and 64-bit Windows           
        // Detect whether the current process is a 32-bit process                
        // running on a 64-bit system.               
        bool result;  
        return ((DoesWin32MethodExist("kernel32.dll", "IsWow64Process") && IsWow64Process(p.Handle, out result)) && result);  
    }  

    /// <summary>     
    /// The function determins whether a method exists in the export      
    /// table of a certain module.     
    /// </summary>     
    /// <param name="moduleName">The name of the module</param>     
    /// <param name="methodName">The name of the method</param>     
    /// <returns>     
    /// The function returns true if the method specified by methodName      
    /// exists in the export table of the module specified by moduleName.     
    /// </returns>       
    static bool DoesWin32MethodExist(string moduleName, string methodName)  
    {  
        IntPtr moduleHandle = GetModuleHandle(moduleName);  
        if (moduleHandle == IntPtr.Zero)  
            return false;    
        return (GetProcAddress(moduleHandle, methodName) != IntPtr.Zero);   
    }  
    [DllImport("kernel32.dll")]  
    static extern IntPtr GetCurrentProcess();  

    [DllImport("kernel32.dll", CharSet = CharSet.Auto)]  
    static extern IntPtr GetModuleHandle(string moduleName);  

    [DllImport("kernel32", CharSet = CharSet.Auto, SetLastError = true)]  
    static extern IntPtr GetProcAddress(IntPtr hModule, [MarshalAs(UnmanagedType.LPStr)]string procName);  

    [DllImport("kernel32.dll", CharSet = CharSet.Auto, SetLastError = true)]  
    [return: MarshalAs(UnmanagedType.Bool)]  
    static extern bool IsWow64Process(IntPtr hProcess, out bool wow64Process);  
}

最快的方式:

if(IntPtr.Size == 8) {
    // 64 bit machine
} else if(IntPtr.Size == 4)  {
    // 32 bit machine
} 

注意:这是非常直接的，只有当程序不强制作为32位进程执行时(例如，在项目设置中通过<Prefer32Bit>true</Prefer32Bit>)，才能在64位上正确工作。

使用dotPeek有助于了解框架是如何实际执行的。考虑到这一点，以下是我的想法:

public static class EnvironmentHelper
{
    [DllImport("kernel32.dll")]
    static extern IntPtr GetCurrentProcess();

    [DllImport("kernel32.dll")]
    static extern IntPtr GetModuleHandle(string moduleName);

    [DllImport("kernel32")]
    static extern IntPtr GetProcAddress(IntPtr hModule, string procName);

    [DllImport("kernel32.dll")]
    static extern bool IsWow64Process(IntPtr hProcess, out bool wow64Process);

    public static bool Is64BitOperatingSystem()
    {
        // Check if this process is natively an x64 process. If it is, it will only run on x64 environments, thus, the environment must be x64.
        if (IntPtr.Size == 8)
            return true;
        // Check if this process is an x86 process running on an x64 environment.
        IntPtr moduleHandle = GetModuleHandle("kernel32");
        if (moduleHandle != IntPtr.Zero)
        {
            IntPtr processAddress = GetProcAddress(moduleHandle, "IsWow64Process");
            if (processAddress != IntPtr.Zero)
            {
                bool result;
                if (IsWow64Process(GetCurrentProcess(), out result) && result)
                    return true;
            }
        }
        // The environment must be an x86 environment.
        return false;
    }
}

使用示例:

EnvironmentHelper.Is64BitOperatingSystem();

对不起，是VB的代码。NET，但是很容易移植到c#。 它可以在Win7, x64和.Net Framework 4.8上正常工作:

Dim r As String = ""
Using searcher As ManagementObjectSearcher = New System.Management.ManagementObjectSearcher("SELECT * FROM Win32_OperatingSystem")
    Dim Information As ManagementObjectCollection = searcher.Get()
    If Information IsNot Nothing Then
        For Each obj As ManagementObject In Information
            r = obj("Caption").ToString() & _
            " - " & _
            obj("OSArchitecture").ToString() ' <--- !!! "64-bit" shown here
        Next
    End If
    MessageBox.Show(r)
End Using

我在许多操作系统上都成功地使用了这个检查:

private bool Is64BitSystem
{
   get
   {
      return Directory.Exists(Environment.ExpandEnvironmentVariables(@"%windir%\SysWOW64"));
   }
}

不管操作系统的语言是什么，这个文件夹总是命名为“SysWOW64”。这适用于。net Framework 1.1或更高版本。