我发现这是检查系统平台和流程的最佳方法:

bool 64BitSystem = Environment.Is64BitOperatingSystem;
bool 64BitProcess = Environment.Is64BitProcess;

第一个属性对于64位系统返回true，对于32位系统返回false。 第二个属性对于64位进程返回true，对于32位进程返回false。

需要这两个属性是因为您可以在64位系统上运行32位进程，因此需要检查系统和进程。

我使用:

Dim drivelet As String = Application.StartupPath.ToString
If Directory.Exists(drivelet(0) & ":\Program Files (x86)") Then
    MsgBox("64bit")
Else
    MsgBox("32bit")
End if

这将获取应用程序启动的路径，以防您将其安装在计算机上的不同位置。此外，你也可以只使用一般的C:\路径，因为99.9%的计算机都在C:\中安装了Windows。

我需要这样做，但我也需要能够作为一个管理员远程做到这一点，无论是哪种情况下，这似乎很适合我:

    public static bool is64bit(String host)
    {
        using (var reg = RegistryKey.OpenRemoteBaseKey(RegistryHive.LocalMachine, host))
        using (var key = reg.OpenSubKey(@"Software\Microsoft\Windows\CurrentVersion\"))
        {
            return key.GetValue("ProgramFilesDir (x86)") !=null;
        }
    }

微软为此提供了一个代码示例:

http://1code.codeplex.com/SourceControl/changeset/view/39074#842775

它是这样的:

    /// <summary>
    /// The function determines whether the current operating system is a 
    /// 64-bit operating system.
    /// </summary>
    /// <returns>
    /// The function returns true if the operating system is 64-bit; 
    /// otherwise, it returns false.
    /// </returns>
    public static bool Is64BitOperatingSystem()
    {
        if (IntPtr.Size == 8)  // 64-bit programs run only on Win64
        {
            return true;
        }
        else  // 32-bit programs run on both 32-bit and 64-bit Windows
        {
            // Detect whether the current process is a 32-bit process 
            // running on a 64-bit system.
            bool flag;
            return ((DoesWin32MethodExist("kernel32.dll", "IsWow64Process") &&
                IsWow64Process(GetCurrentProcess(), out flag)) && flag);
        }
    }

    /// <summary>
    /// The function determins whether a method exists in the export 
    /// table of a certain module.
    /// </summary>
    /// <param name="moduleName">The name of the module</param>
    /// <param name="methodName">The name of the method</param>
    /// <returns>
    /// The function returns true if the method specified by methodName 
    /// exists in the export table of the module specified by moduleName.
    /// </returns>
    static bool DoesWin32MethodExist(string moduleName, string methodName)
    {
        IntPtr moduleHandle = GetModuleHandle(moduleName);
        if (moduleHandle == IntPtr.Zero)
        {
            return false;
        }
        return (GetProcAddress(moduleHandle, methodName) != IntPtr.Zero);
    }

    [DllImport("kernel32.dll")]
    static extern IntPtr GetCurrentProcess();

    [DllImport("kernel32.dll", CharSet = CharSet.Auto)]
    static extern IntPtr GetModuleHandle(string moduleName);

    [DllImport("kernel32", CharSet = CharSet.Auto, SetLastError = true)]
    static extern IntPtr GetProcAddress(IntPtr hModule,
        [MarshalAs(UnmanagedType.LPStr)]string procName);

    [DllImport("kernel32.dll", CharSet = CharSet.Auto, SetLastError = true)]
    [return: MarshalAs(UnmanagedType.Bool)]
    static extern bool IsWow64Process(IntPtr hProcess, out bool wow64Process);

还有一个可用的WMI版本(用于测试远程机器)。

这只是Bruno Lopez上面建议的一个实现，但适用于Win2k +所有的WinXP服务包。我只是想把它贴出来这样别人就不用亲手卷了。(本可以作为评论发布，但我是一个新用户!)

[DllImport("kernel32", SetLastError = true, CallingConvention = CallingConvention.Winapi)]
public extern static IntPtr LoadLibrary(string libraryName);

[DllImport("kernel32", SetLastError = true, CallingConvention = CallingConvention.Winapi)]
public extern static IntPtr GetProcAddress(IntPtr hwnd, string procedureName);

private delegate bool IsWow64ProcessDelegate([In] IntPtr handle, [Out] out bool isWow64Process);

public static bool IsOS64Bit()
{
    if (IntPtr.Size == 8 || (IntPtr.Size == 4 && Is32BitProcessOn64BitProcessor()))
    {
        return true;
    }
    else
    {
        return false;
    }
}

private static IsWow64ProcessDelegate GetIsWow64ProcessDelegate()
{
  IntPtr handle = LoadLibrary("kernel32");

  if ( handle != IntPtr.Zero)
  {
    IntPtr fnPtr = GetProcAddress(handle, "IsWow64Process");

    if (fnPtr != IntPtr.Zero)
    {
      return (IsWow64ProcessDelegate)Marshal.GetDelegateForFunctionPointer((IntPtr)fnPtr, typeof(IsWow64ProcessDelegate));
    }
  }

  return null;
}

private static bool Is32BitProcessOn64BitProcessor()
{
  IsWow64ProcessDelegate fnDelegate = GetIsWow64ProcessDelegate();

  if (fnDelegate == null)
  {
    return false;
  }

  bool isWow64;
  bool retVal = fnDelegate.Invoke(Process.GetCurrentProcess().Handle, out isWow64);

  if (retVal == false)
  {
    return false;
  }

  return isWow64;
}

使用dotPeek有助于了解框架是如何实际执行的。考虑到这一点，以下是我的想法:

public static class EnvironmentHelper
{
    [DllImport("kernel32.dll")]
    static extern IntPtr GetCurrentProcess();

    [DllImport("kernel32.dll")]
    static extern IntPtr GetModuleHandle(string moduleName);

    [DllImport("kernel32")]
    static extern IntPtr GetProcAddress(IntPtr hModule, string procName);

    [DllImport("kernel32.dll")]
    static extern bool IsWow64Process(IntPtr hProcess, out bool wow64Process);

    public static bool Is64BitOperatingSystem()
    {
        // Check if this process is natively an x64 process. If it is, it will only run on x64 environments, thus, the environment must be x64.
        if (IntPtr.Size == 8)
            return true;
        // Check if this process is an x86 process running on an x64 environment.
        IntPtr moduleHandle = GetModuleHandle("kernel32");
        if (moduleHandle != IntPtr.Zero)
        {
            IntPtr processAddress = GetProcAddress(moduleHandle, "IsWow64Process");
            if (processAddress != IntPtr.Zero)
            {
                bool result;
                if (IsWow64Process(GetCurrentProcess(), out result) && result)
                    return true;
            }
        }
        // The environment must be an x86 environment.
        return false;
    }
}

使用示例:

EnvironmentHelper.Is64BitOperatingSystem();