用signal注册你的处理程序。信号是这样的:

#!/usr/bin/env python
import signal
import sys

def signal_handler(sig, frame):
    print('You pressed Ctrl+C!')
    sys.exit(0)

signal.signal(signal.SIGINT, signal_handler)
print('Press Ctrl+C')
signal.pause()

代码改编自这里。

更多关于信号的文档可以在这里找到。  

你可以像对待其他异常一样对待它(KeyboardInterrupt)。创建一个新文件，并在shell中运行它，包含以下内容，看看我的意思:

import time, sys

x = 1
while True:
    try:
        print x
        time.sleep(.3)
        x += 1
    except KeyboardInterrupt:
        print "Bye"
        sys.exit()

你可以通过捕获KeyboardInterrupt异常来处理CTRL+C。您可以在异常处理程序中实现任何清理代码。

感谢已有的答案，但添加了signal.getsignal()

import signal

# store default handler of signal.SIGINT
default_handler = signal.getsignal(signal.SIGINT)
catch_count = 0

def handler(signum, frame):
    global default_handler, catch_count
    catch_count += 1
    print ('wait:', catch_count)
    if catch_count > 3:
        # recover handler for signal.SIGINT
        signal.signal(signal.SIGINT, default_handler)
        print('expecting KeyboardInterrupt')

signal.signal(signal.SIGINT, handler)
print('Press Ctrl+c here')

while True:
    pass

如果你想确保你的清理过程完成，我将通过使用SIG_IGN添加到Matt J的答案，这样进一步的SIGINT将被忽略，这将防止你的清理被打断。

import signal
import sys

def signal_handler(signum, frame):
    signal.signal(signum, signal.SIG_IGN) # ignore additional signals
    cleanup() # give your process a chance to clean up
    sys.exit(0)

signal.signal(signal.SIGINT, signal_handler) # register the signal with the signal handler first
do_stuff()

来自Python的文档:

import signal
import time

def handler(signum, frame):
    print 'Here you go'

signal.signal(signal.SIGINT, handler)

time.sleep(10) # Press Ctrl+c here