来自Python的文档:

import signal
import time

def handler(signum, frame):
    print 'Here you go'

signal.signal(signal.SIGINT, handler)

time.sleep(10) # Press Ctrl+c here

作为一个上下文管理器:

import signal

class GracefulInterruptHandler(object):

    def __init__(self, sig=signal.SIGINT):
        self.sig = sig

    def __enter__(self):

        self.interrupted = False
        self.released = False

        self.original_handler = signal.getsignal(self.sig)

        def handler(signum, frame):
            self.release()
            self.interrupted = True

        signal.signal(self.sig, handler)

        return self

    def __exit__(self, type, value, tb):
        self.release()

    def release(self):

        if self.released:
            return False

        signal.signal(self.sig, self.original_handler)

        self.released = True

        return True

使用方法:

with GracefulInterruptHandler() as h:
    for i in xrange(1000):
        print "..."
        time.sleep(1)
        if h.interrupted:
            print "interrupted!"
            time.sleep(2)
            break

嵌套的处理程序:

with GracefulInterruptHandler() as h1:
    while True:
        print "(1)..."
        time.sleep(1)
        with GracefulInterruptHandler() as h2:
            while True:
                print "\t(2)..."
                time.sleep(1)
                if h2.interrupted:
                    print "\t(2) interrupted!"
                    time.sleep(2)
                    break
        if h1.interrupted:
            print "(1) interrupted!"
            time.sleep(2)
            break

网址:https://gist.github.com/2907502

用signal注册你的处理程序。信号是这样的:

#!/usr/bin/env python
import signal
import sys

def signal_handler(sig, frame):
    print('You pressed Ctrl+C!')
    sys.exit(0)

signal.signal(signal.SIGINT, signal_handler)
print('Press Ctrl+C')
signal.pause()

代码改编自这里。

更多关于信号的文档可以在这里找到。  

如果你想确保你的清理过程完成，我将通过使用SIG_IGN添加到Matt J的答案，这样进一步的SIGINT将被忽略，这将防止你的清理被打断。

import signal
import sys

def signal_handler(signum, frame):
    signal.signal(signum, signal.SIG_IGN) # ignore additional signals
    cleanup() # give your process a chance to clean up
    sys.exit(0)

signal.signal(signal.SIGINT, signal_handler) # register the signal with the signal handler first
do_stuff()

感谢已有的答案，但添加了signal.getsignal()

import signal

# store default handler of signal.SIGINT
default_handler = signal.getsignal(signal.SIGINT)
catch_count = 0

def handler(signum, frame):
    global default_handler, catch_count
    catch_count += 1
    print ('wait:', catch_count)
    if catch_count > 3:
        # recover handler for signal.SIGINT
        signal.signal(signal.SIGINT, default_handler)
        print('expecting KeyboardInterrupt')

signal.signal(signal.SIGINT, handler)
print('Press Ctrl+c here')

while True:
    pass

你可以像对待其他异常一样对待它(KeyboardInterrupt)。创建一个新文件，并在shell中运行它，包含以下内容，看看我的意思:

import time, sys

x = 1
while True:
    try:
        print x
        time.sleep(.3)
        x += 1
    except KeyboardInterrupt:
        print "Bye"
        sys.exit()