这将执行高质量的调整大小:

/// <summary>
/// Resize the image to the specified width and height.
/// </summary>
/// <param name="image">The image to resize.</param>
/// <param name="width">The width to resize to.</param>
/// <param name="height">The height to resize to.</param>
/// <returns>The resized image.</returns>
public static Bitmap ResizeImage(Image image, int width, int height)
{
    var destRect = new Rectangle(0, 0, width, height);
    var destImage = new Bitmap(width, height);

    destImage.SetResolution(image.HorizontalResolution, image.VerticalResolution);

    using (var graphics = Graphics.FromImage(destImage))
    {
        graphics.CompositingMode = CompositingMode.SourceCopy;
        graphics.CompositingQuality = CompositingQuality.HighQuality;
        graphics.InterpolationMode = InterpolationMode.HighQualityBicubic;
        graphics.SmoothingMode = SmoothingMode.HighQuality;
        graphics.PixelOffsetMode = PixelOffsetMode.HighQuality;

        using (var wrapMode = new ImageAttributes())
        {
            wrapMode.SetWrapMode(WrapMode.TileFlipXY);
            graphics.DrawImage(image, destRect, 0, 0, image.Width,image.Height, GraphicsUnit.Pixel, wrapMode);
        }
    }

    return destImage;
}

wrapMode.SetWrapMode(WrapMode.TileFlipXY) prevents ghosting around the image borders -- naïve resizing will sample transparent pixels beyond the image boundaries, but by mirroring the image we can get a better sample (this setting is very noticeable) destImage.SetResolution maintains DPI regardless of physical size -- may increase quality when reducing image dimensions or when printing Compositing controls how pixels are blended with the background -- might not be needed since we're only drawing one thing. graphics.CompositingMode determines whether pixels from a source image overwrite or are combined with background pixels. SourceCopy specifies that when a color is rendered, it overwrites the background color. graphics.CompositingQuality determines the rendering quality level of layered images. graphics.InterpolationMode determines how intermediate values between two endpoints are calculated graphics.SmoothingMode specifies whether lines, curves, and the edges of filled areas use smoothing (also called antialiasing) -- probably only works on vectors graphics.PixelOffsetMode affects rendering quality when drawing the new image

保持纵横比是留给读者的练习(实际上，我只是不认为这个函数的工作是为您做这件事)。

此外，这是一篇很好的文章，描述了调整图像大小的一些陷阱。上面的函数将涵盖其中的大部分，但您仍然需要担心保存。

在我做的应用程序中，有必要创建一个具有多个选项的函数。它相当大，但它可以调整图像的大小，可以保持纵横比，并可以切割边缘，只返回图像的中心:

/// <summary>
    /// Resize image with a directory as source
    /// </summary>
    /// <param name="OriginalFileLocation">Image location</param>
    /// <param name="heigth">new height</param>
    /// <param name="width">new width</param>
    /// <param name="keepAspectRatio">keep the aspect ratio</param>
    /// <param name="getCenter">return the center bit of the image</param>
    /// <returns>image with new dimentions</returns>
    public Image resizeImageFromFile(String OriginalFileLocation, int heigth, int width, Boolean keepAspectRatio, Boolean getCenter)
    {
        int newheigth = heigth;
        System.Drawing.Image FullsizeImage = System.Drawing.Image.FromFile(OriginalFileLocation);

        // Prevent using images internal thumbnail
        FullsizeImage.RotateFlip(System.Drawing.RotateFlipType.Rotate180FlipNone);
        FullsizeImage.RotateFlip(System.Drawing.RotateFlipType.Rotate180FlipNone);

        if (keepAspectRatio || getCenter)
        {
            int bmpY = 0;
            double resize = (double)FullsizeImage.Width / (double)width;//get the resize vector
            if (getCenter)
            {
                bmpY = (int)((FullsizeImage.Height - (heigth * resize)) / 2);// gives the Y value of the part that will be cut off, to show only the part in the center
                Rectangle section = new Rectangle(new Point(0, bmpY), new Size(FullsizeImage.Width, (int)(heigth * resize)));// create the section to cut of the original image
                //System.Console.WriteLine("the section that will be cut off: " + section.Size.ToString() + " the Y value is minimized by: " + bmpY);
                Bitmap orImg = new Bitmap((Bitmap)FullsizeImage);//for the correct effect convert image to bitmap.
                FullsizeImage.Dispose();//clear the original image
                using (Bitmap tempImg = new Bitmap(section.Width, section.Height))
                {
                    Graphics cutImg = Graphics.FromImage(tempImg);//              set the file to save the new image to.
                    cutImg.DrawImage(orImg, 0, 0, section, GraphicsUnit.Pixel);// cut the image and save it to tempImg
                    FullsizeImage = tempImg;//save the tempImg as FullsizeImage for resizing later
                    orImg.Dispose();
                    cutImg.Dispose();
                    return FullsizeImage.GetThumbnailImage(width, heigth, null, IntPtr.Zero);
                }
            }
            else newheigth = (int)(FullsizeImage.Height / resize);//  set the new heigth of the current image
        }//return the image resized to the given heigth and width
        return FullsizeImage.GetThumbnailImage(width, newheigth, null, IntPtr.Zero);
    }

为了更容易访问函数，可以添加一些重载函数:

/// <summary>
    /// Resize image with a directory as source
    /// </summary>
    /// <param name="OriginalFileLocation">Image location</param>
    /// <param name="heigth">new height</param>
    /// <param name="width">new width</param>
    /// <returns>image with new dimentions</returns>
    public Image resizeImageFromFile(String OriginalFileLocation, int heigth, int width)
    {
        return resizeImageFromFile(OriginalFileLocation, heigth, width, false, false);
    }

    /// <summary>
    /// Resize image with a directory as source
    /// </summary>
    /// <param name="OriginalFileLocation">Image location</param>
    /// <param name="heigth">new height</param>
    /// <param name="width">new width</param>
    /// <param name="keepAspectRatio">keep the aspect ratio</param>
    /// <returns>image with new dimentions</returns>
    public Image resizeImageFromFile(String OriginalFileLocation, int heigth, int width, Boolean keepAspectRatio)
    {
        return resizeImageFromFile(OriginalFileLocation, heigth, width, keepAspectRatio, false);
    }

现在是最后两个可选的布尔值。 像这样调用函数:

System.Drawing.Image ResizedImage = resizeImageFromFile(imageLocation, 800, 400, true, true);

这将执行高质量的调整大小:

/// <summary>
/// Resize the image to the specified width and height.
/// </summary>
/// <param name="image">The image to resize.</param>
/// <param name="width">The width to resize to.</param>
/// <param name="height">The height to resize to.</param>
/// <returns>The resized image.</returns>
public static Bitmap ResizeImage(Image image, int width, int height)
{
    var destRect = new Rectangle(0, 0, width, height);
    var destImage = new Bitmap(width, height);

    destImage.SetResolution(image.HorizontalResolution, image.VerticalResolution);

    using (var graphics = Graphics.FromImage(destImage))
    {
        graphics.CompositingMode = CompositingMode.SourceCopy;
        graphics.CompositingQuality = CompositingQuality.HighQuality;
        graphics.InterpolationMode = InterpolationMode.HighQualityBicubic;
        graphics.SmoothingMode = SmoothingMode.HighQuality;
        graphics.PixelOffsetMode = PixelOffsetMode.HighQuality;

        using (var wrapMode = new ImageAttributes())
        {
            wrapMode.SetWrapMode(WrapMode.TileFlipXY);
            graphics.DrawImage(image, destRect, 0, 0, image.Width,image.Height, GraphicsUnit.Pixel, wrapMode);
        }
    }

    return destImage;
}

wrapMode.SetWrapMode(WrapMode.TileFlipXY) prevents ghosting around the image borders -- naïve resizing will sample transparent pixels beyond the image boundaries, but by mirroring the image we can get a better sample (this setting is very noticeable) destImage.SetResolution maintains DPI regardless of physical size -- may increase quality when reducing image dimensions or when printing Compositing controls how pixels are blended with the background -- might not be needed since we're only drawing one thing. graphics.CompositingMode determines whether pixels from a source image overwrite or are combined with background pixels. SourceCopy specifies that when a color is rendered, it overwrites the background color. graphics.CompositingQuality determines the rendering quality level of layered images. graphics.InterpolationMode determines how intermediate values between two endpoints are calculated graphics.SmoothingMode specifies whether lines, curves, and the edges of filled areas use smoothing (also called antialiasing) -- probably only works on vectors graphics.PixelOffsetMode affects rendering quality when drawing the new image

保持纵横比是留给读者的练习(实际上，我只是不认为这个函数的工作是为您做这件事)。

此外，这是一篇很好的文章，描述了调整图像大小的一些陷阱。上面的函数将涵盖其中的大部分，但您仍然需要担心保存。

这是我为特定要求编写的代码，即:目的地总是在景观比例。这会给你一个好的开始。

public Image ResizeImage(Image source, RectangleF destinationBounds)
{
    RectangleF sourceBounds = new RectangleF(0.0f,0.0f,(float)source.Width, (float)source.Height);
    RectangleF scaleBounds = new RectangleF();

    Image destinationImage = new Bitmap((int)destinationBounds.Width, (int)destinationBounds.Height);
    Graphics graph = Graphics.FromImage(destinationImage);
    graph.InterpolationMode =
        System.Drawing.Drawing2D.InterpolationMode.HighQualityBicubic;

    // Fill with background color
    graph.FillRectangle(new SolidBrush(System.Drawing.Color.White), destinationBounds);

    float resizeRatio, sourceRatio;
    float scaleWidth, scaleHeight;

    sourceRatio = (float)source.Width / (float)source.Height;

    if (sourceRatio >= 1.0f)
    {
        //landscape
        resizeRatio = destinationBounds.Width / sourceBounds.Width;
        scaleWidth = destinationBounds.Width;
        scaleHeight = sourceBounds.Height * resizeRatio;
        float trimValue = destinationBounds.Height - scaleHeight;
        graph.DrawImage(source, 0, (trimValue / 2), destinationBounds.Width, scaleHeight);
    }
    else
    {
        //portrait
        resizeRatio = destinationBounds.Height/sourceBounds.Height;
        scaleWidth = sourceBounds.Width * resizeRatio;
        scaleHeight = destinationBounds.Height;
        float trimValue = destinationBounds.Width - scaleWidth;
        graph.DrawImage(source, (trimValue / 2), 0, scaleWidth, destinationBounds.Height);
    }

    return destinationImage;

}

为什么不用System.Drawing.Image.GetThumbnailImage方法呢?

public Image GetThumbnailImage(
    int thumbWidth, 
    int thumbHeight, 
    Image.GetThumbnailImageAbort callback, 
    IntPtr callbackData)

例子:

Image originalImage = System.Drawing.Image.FromStream(inputStream, true, true);
Image resizedImage = originalImage.GetThumbnailImage(newWidth, (newWidth * originalImage.Height) / originalWidth, null, IntPtr.Zero);
resizedImage.Save(imagePath, ImageFormat.Png);

来源: http://msdn.microsoft.com/en-us/library/system.drawing.image.getthumbnailimage.aspx

注意:这将不适用于ASP。因为WebImage依赖于系统。Web，但在以前版本的ASP。我在Net中多次使用了这个片段，它很有用。

String ThumbfullPath = Path.GetFileNameWithoutExtension(file.FileName) + "80x80.jpg";
var ThumbfullPath2 = Path.Combine(ThumbfullPath, fileThumb);
using (MemoryStream stream = new MemoryStream(System.IO.File.ReadAllBytes(fullPath)))
{
      var thumbnail = new WebImage(stream).Resize(80, 80);
      thumbnail.Save(ThumbfullPath2, "jpg");
}