我需要补充另一个答案，因为就像Craig Glennie一样，由于网上有许多提到这个问题的帖子，我进行了一次徒劳的追逐。

我正在使用MacPorts，我最初认为的Python问题实际上是MacPorts问题:它在安装openssl时没有安装根证书。解决方案是移植安装curl-ca-bundle，如本文所述。

Craig Glennie的回答是:

MacOs Sierra上的Python 3.6.1

在bash终端中输入这个可以解决问题:

pip install certifi
/Applications/Python\ 3.6/Install\ Certificates.command

如果你有私人证书要处理，比如你的组织自己的CA根和链的中间部分，那么最好将证书添加到CA文件中，即cacert。pem，而不是绕过整个安全设备(verify=False)。下面的代码让你在2.7+和3+

考虑添加整个证书链，当然您只需要这样做一次。

import certifi

cafile=certifi.where() # cacert file
with open ('rootca.pem','rb') as infile:
    customca=infile.read()
    with open(cafile,'ab') as outfile:
        outfile.write(customca)
with open ('interca.pem','rb') as infile:
    customca=infile.read()
    with open(cafile,'ab') as outfile:
        outfile.write(customca)
with open ('issueca.pem','rb') as infile:
    customca=infile.read()
    with open(cafile,'ab') as outfile:
        outfile.write(customca)

那这个应该能让你振作起来

import requests
response = requests.request("GET", 'https://yoursecuresite.com',  data = {})
print(response.text.encode('utf8'))

希望这能有所帮助

在我的情况下，我得到这个错误，因为请求和urllib3版本不兼容，在安装期间给出以下错误:

ERROR: requests 2.21.0 has requirement urllib3<1.25,>=1.21.1, but you'll have urllib3 1.25 which is incompatible.

pip install 'urllib3<1.25' --force-reinstall

成功了。

我有点羞愧地低下头，因为我也遇到了同样的问题，只不过在我的情况下，我点击的URL是有效的，证书是有效的。无效的是我的网络连接。我未能将代理详细信息添加到浏览器(在这种情况下是IE)。这阻止了验证过程的正确进行。 添加了代理细节，我的python非常高兴。

The SSL: CERTIFICATE_VERIFY_FAILED error could also occur because an Intermediate Certificate is missing in the ca-certificates package on Linux. For example, in my case the intermediate certificate "DigiCert SHA2 Secure Server CA" was missing in the ca-certificates package even though the Firefox browser includes it. You can find out which certificate is missing by directly running the wget command on the URL causing this error. Then you can search for the corresponding link to the CRT file for this certificate from the official website (e.g. https://www.digicert.com/digicert-root-certificates.htm in my case) of the Certificate Authority. Now, to include the certificate that is missing in your case, you may run the below commands using your CRT file download link instead:

wget https://cacerts.digicert.com/DigiCertSHA2SecureServerCA.crt

mv DigiCertSHA2SecureServerCA.crt DigiCertSHA2SecureServerCA.der

openssl x509 -inform DER -outform PEM -in DigiCertSHA2SecureServerCA.der -out DigicertSHA2SecureServerCA.pem.crt

sudo mkdir /usr/share/ca-certificates/extra

sudo cp DigicertSHA2SecureServerCA.pem.crt /usr/share/ca-certificates/extra/

sudo dpkg-reconfigure ca-certificates

在此之后，您可以再次使用wget测试URL，也可以使用python urllib包进行测试。详情请参考:https://bugs.launchpad.net/ubuntu/+source/ca-certificates/+bug/1795242