如果你想要更多的控制，你可能想检查TextPaint类。下面是如何使用它:

final ClickableSpan clickableSpan = new ClickableSpan() {
    @Override
    public void onClick(final View textView) {
        //Your onClick code here
    }

    @Override
    public void updateDrawState(final TextPaint textPaint) {
        textPaint.setColor(yourContext.getResources().getColor(R.color.orange));
        textPaint.setUnderlineText(true);
    }
};

这是一个帮助函数。当你有多种语言的时候非常有用!

private void setColor(TextView view, String fulltext, String subtext, int color) {
    view.setText(fulltext, TextView.BufferType.SPANNABLE);
    Spannable str = (Spannable) view.getText();
    int i = fulltext.indexOf(subtext);
    str.setSpan(new ForegroundColorSpan(color), i, i + subtext.length(), Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
}

设置你的TextView的文本跨度，并为你的文本定义一个ForegroundColorSpan。

TextView textView = (TextView)findViewById(R.id.mytextview01);    
Spannable wordtoSpan = new SpannableString("I know just how to whisper, And I know just how to cry,I know just where to find the answers");          
wordtoSpan.setSpan(new ForegroundColorSpan(Color.BLUE), 15, 30, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);    
textView.setText(wordtoSpan);

如果你想要更多的控制，你可能想检查TextPaint类。下面是如何使用它:

final ClickableSpan clickableSpan = new ClickableSpan() {
    @Override
    public void onClick(final View textView) {
        //Your onClick code here
    }

    @Override
    public void updateDrawState(final TextPaint textPaint) {
        textPaint.setColor(yourContext.getResources().getColor(R.color.orange));
        textPaint.setUnderlineText(true);
    }
};

当我试图理解一个新概念时，我总是发现视觉例子很有帮助。

背景颜色

SpannableString spannableString = new SpannableString("Hello World!");
BackgroundColorSpan backgroundSpan = new BackgroundColorSpan(Color.YELLOW);
spannableString.setSpan(backgroundSpan, 0, spannableString.length(), Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
textView.setText(spannableString);

前景颜色

SpannableString spannableString = new SpannableString("Hello World!");
ForegroundColorSpan foregroundSpan = new ForegroundColorSpan(Color.RED);
spannableString.setSpan(foregroundSpan, 0, spannableString.length(), Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
textView.setText(spannableString);

结合

SpannableString spannableString = new SpannableString("Hello World!");
ForegroundColorSpan foregroundSpan = new ForegroundColorSpan(Color.RED);
BackgroundColorSpan backgroundSpan = new BackgroundColorSpan(Color.YELLOW);
spannableString.setSpan(foregroundSpan, 0, 8, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
spannableString.setSpan(backgroundSpan, 3, spannableString.length(), Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);
textView.setText(spannableString);

进一步的研究

解释SPAN_EXCLUSIVE_EXCLUSIVE等Span标志的含义 Android Spanned, SpannedString, Spannable, SpannableString和CharSequence

另一个答案将非常相似，但不需要设置TextView的文本两次

TextView TV = (TextView)findViewById(R.id.mytextview01);

Spannable wordtoSpan = new SpannableString("I know just how to whisper, And I know just how to cry,I know just where to find the answers");        

wordtoSpan.setSpan(new ForegroundColorSpan(Color.BLUE), 15, 30, Spannable.SPAN_EXCLUSIVE_EXCLUSIVE);

TV.setText(wordtoSpan);