有人使用bootstrap-sass (v3)，下面是使用bootstrap混合的5列的简单代码:

  .col-xs-5ths {
     @include make-xs-column(2.4);
  }

  @media (min-width: $screen-sm-min) {
     .col-sm-5ths {
        @include make-sm-column(2.4);
     }
  }

  @media (min-width: $screen-md-min) {
     .col-md-5ths {
        @include make-md-column(2.4);
     }
  }

  @media (min-width: $screen-lg-min) {
     .col-lg-5ths {
        @include make-lg-column(2.4);
     }
  }

确保你已经包括:

@import "bootstrap/variables";
@import "bootstrap/mixins";

对于@lightswitch的回答，如果我们需要使用更少迭代的5列网格

.make-fifth-col(@index) when (@index > 0) {
  @class-name: ~".col-md-5th-@{index}";

  @{class-name} {
    .make-md-column(1.2*@index);
  }

  .make-fifth-col(@index - 1);
}

.make-fifth-col(10);

这将生成css类。col-md-5th-1, col-md-5th-2, col-md-5th-3，等等，对应10%，20%，30%…分别

保持原始的12列引导，不要自定义它。你唯一需要做的修改是一些css之后的原始引导响应css，像这样:

下面的代码已经为Bootstrap 2.3.2进行了测试:

<style type="text/css">
/* start of modification for 5 columns */
@media (min-width: 768px){
    .fivecolumns .span2 {
        width: 18.297872340425532%;
        *width: 18.2234042553191494%;
    }
}
@media (min-width: 1200px) {
    .fivecolumns .span2 {
        width: 17.9487179487179488%;
        *width: 17.87424986361156592%;
    }
}
@media (min-width: 768px) and (max-width: 979px) {
    .fivecolumns .span2 {
        width: 17.79005524861878448%;
        *width: 17.7155871635124022%;
    }
}
/* end of modification for 5 columns */
</style>

和html:

<div class="row-fluid fivecolumns">
    <div class="span2">
        <h2>Heading</h2>
        <p>Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p>
        <p><a class="btn" href="#">View details &raquo;</a></p>
    </div>
    <div class="span2">
        <h2>Heading</h2>
        <p>Donec id elit non mi porta gravida at eget metus. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus. Etiam porta sem malesuada magna mollis euismod. Donec sed odio dui. </p>
        <p><a class="btn" href="#">View details &raquo;</a></p>
    </div>
    <div class="span2">
        <h2>Heading</h2>
        <p>Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Vestibulum id ligula porta felis euismod semper. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus.</p>
        <p><a class="btn" href="#">View details &raquo;</a></p>
    </div>
    <div class="span2">
        <h2>Heading</h2>
        <p>Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Vestibulum id ligula porta felis euismod semper. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus.</p>
        <p><a class="btn" href="#">View details &raquo;</a></p>
    </div>
    <div class="span2">
        <h2>Heading</h2>
        <p>Donec sed odio dui. Cras justo odio, dapibus ac facilisis in, egestas eget quam. Vestibulum id ligula porta felis euismod semper. Fusce dapibus, tellus ac cursus commodo, tortor mauris condimentum nibh, ut fermentum massa justo sit amet risus.</p>
        <p><a class="btn" href="#">View details &raquo;</a></p>
    </div>
</div>

注意:即使span2乘以5不等于12列，你明白了吧:)

可以在这里找到一个工作示例http://jsfiddle.net/v3Uy5/6/

我对Mafnah的答案进行了投票，但再看一遍，如果你保持默认的边际，我建议下面的答案更好。

<div class="equal row-fluid">
    <div class="span2"></div>
    <div class="span2"></div>
    <div class="span2"></div>
    <div class="span2"></div>
    <div class="span2"></div>
</div>

.equal .span2 {
    width: 17.9%;
}

var cols = $(".container .item").length;
if (cols == 5){
    $('div.item').removeClass('col-md-2..etc').addClass('col-md-3').css('width', '20%');
 }

Jquery和完成!框架!

.col-xs-2-4 { position: relative; float: left; width: 20%; min-height: 1px; padding-left: 15px; padding-right: 15px; } .col-sm-2-4 { position: relative; min-height: 1px; padding-left: 15px; padding-right: 15px; } @media (min-width: 768px) { .col-sm-2-4 { float: left; width: 20%; } } .col-md-2-4 { position: relative; min-height: 1px; padding-left: 15px; padding-right: 15px; } @media (min-width: 992px) { .col-md-2-4 { float: left; width: 20%; } } .col-lg-2-4 { position: relative; min-height: 1px; padding-left: 15px; padding-right: 15px; } @media (min-width: 1200px) { .col-lg-2-4 { float: left; width: 20%; } }