提问者几乎就说到了。像Python中的大多数事情一样，答案比您想象的要简单。

>>> line = "H E?.LL!/;O:: "  
>>> for char in ' ?.!/;:':  
...  line = line.replace(char,'')  
...
>>> print line
HELLO

你不需要做嵌套的if/for循环，但你确实需要单独检查每个字符。

你可以使用re模块的正则表达式替换。使用^表达式可以准确地从字符串中选择想要的内容。

    import re
    text = "This is absurd!"
    text = re.sub("[^a-zA-Z]","",text) # Keeps only Alphabets
    print(text)

输出结果将是“这是荒谬的”。只有在^符号之后指定的内容才会出现。

>>> line = "abc#@!?efg12;:?"
>>> ''.join( c for c in line if  c not in '?:!/;' )
'abc#@efg12'

这是我的Python 2/3兼容版本。因为翻译api已经改变了。

def remove(str_, chars):
    """Removes each char in `chars` from `str_`.

    Args:
        str_: String to remove characters from
        chars: String of to-be removed characters

    Returns:
        A copy of str_ with `chars` removed

    Example:
            remove("What?!?: darn;", " ?.!:;") => 'Whatdarn'
    """
    try:
        # Python2.x
        return str_.translate(None, chars)
    except TypeError:
        # Python 3.x
        table = {ord(char): None for char in chars}
        return str_.translate(table)

我是不是错过了重点，或者仅仅是以下几点:

string = "ab1cd1ef"
string = string.replace("1", "") 

print(string)
# result: "abcdef"

把它放入循环:

a = "a!b@c#d$"
b = "!@#$"
for char in b:
    a = a.replace(char, "")

print(a)
# result: "abcd"

>>> s = 'a1b2c3'
>>> ''.join(c for c in s if c not in '123')
'abc'