我尝试了Viachaslau的答案，因为我喜欢不移除按钮而是禁用它的想法，但由于某种原因，它并不总是有效:关闭按钮仍然被启用，但没有任何错误。

另一方面，这总是有效的(错误检查省略):

[DllImport( "user32.dll" )]
private static extern IntPtr GetSystemMenu( IntPtr hWnd, bool bRevert );
[DllImport( "user32.dll" )]
private static extern bool EnableMenuItem( IntPtr hMenu, uint uIDEnableItem, uint uEnable );

private const uint MF_BYCOMMAND = 0x00000000;
private const uint MF_GRAYED = 0x00000001;
private const uint SC_CLOSE = 0xF060;
private const int WM_SHOWWINDOW = 0x00000018;

protected override void OnSourceInitialized( EventArgs e )
{
  base.OnSourceInitialized( e );
  var hWnd = new WindowInteropHelper( this );
  var sysMenu = GetSystemMenu( hWnd.Handle, false );
  EnableMenuItem( sysMenu, SC_CLOSE, MF_BYCOMMAND | MF_GRAYED );
}

要设置的属性是=> WindowStyle="None"

<Window x:Class="mdaframework.MainWindow"
            xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
            xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
            Title="Start" Height="350" Width="525" ResizeMode="NoResize"  WindowStartupLocation="CenterScreen" WindowStyle="None">

我刚遇到类似的问题，乔怀特的解决方案似乎对我来说简单而干净。我重用了它，并将其定义为Window的附加属性

public class WindowBehavior
{
    private static readonly Type OwnerType = typeof (WindowBehavior);

    #region HideCloseButton (attached property)

    public static readonly DependencyProperty HideCloseButtonProperty =
        DependencyProperty.RegisterAttached(
            "HideCloseButton",
            typeof (bool),
            OwnerType,
            new FrameworkPropertyMetadata(false, new PropertyChangedCallback(HideCloseButtonChangedCallback)));

    [AttachedPropertyBrowsableForType(typeof(Window))]
    public static bool GetHideCloseButton(Window obj) {
        return (bool)obj.GetValue(HideCloseButtonProperty);
    }

    [AttachedPropertyBrowsableForType(typeof(Window))]
    public static void SetHideCloseButton(Window obj, bool value) {
        obj.SetValue(HideCloseButtonProperty, value);
    }

    private static void HideCloseButtonChangedCallback(DependencyObject d, DependencyPropertyChangedEventArgs e)
    {
        var window = d as Window;
        if (window == null) return;

        var hideCloseButton = (bool)e.NewValue;
        if (hideCloseButton && !GetIsHiddenCloseButton(window)) {
            if (!window.IsLoaded) {
                window.Loaded += HideWhenLoadedDelegate;
            }
            else {
                HideCloseButton(window);
            }
            SetIsHiddenCloseButton(window, true);
        }
        else if (!hideCloseButton && GetIsHiddenCloseButton(window)) {
            if (!window.IsLoaded) {
                window.Loaded -= ShowWhenLoadedDelegate;
            }
            else {
                ShowCloseButton(window);
            }
            SetIsHiddenCloseButton(window, false);
        }
    }

    #region Win32 imports

    private const int GWL_STYLE = -16;
    private const int WS_SYSMENU = 0x80000;
    [DllImport("user32.dll", SetLastError = true)]
    private static extern int GetWindowLong(IntPtr hWnd, int nIndex);
    [DllImport("user32.dll")]
    private static extern int SetWindowLong(IntPtr hWnd, int nIndex, int dwNewLong);

    #endregion

    private static readonly RoutedEventHandler HideWhenLoadedDelegate = (sender, args) => {
        if (sender is Window == false) return;
        var w = (Window)sender;
        HideCloseButton(w);
        w.Loaded -= HideWhenLoadedDelegate;
    };

    private static readonly RoutedEventHandler ShowWhenLoadedDelegate = (sender, args) => {
        if (sender is Window == false) return;
        var w = (Window)sender;
        ShowCloseButton(w);
        w.Loaded -= ShowWhenLoadedDelegate;
    };

    private static void HideCloseButton(Window w) {
        var hwnd = new WindowInteropHelper(w).Handle;
        SetWindowLong(hwnd, GWL_STYLE, GetWindowLong(hwnd, GWL_STYLE) & ~WS_SYSMENU);
    }

    private static void ShowCloseButton(Window w) {
        var hwnd = new WindowInteropHelper(w).Handle;
        SetWindowLong(hwnd, GWL_STYLE, GetWindowLong(hwnd, GWL_STYLE) | WS_SYSMENU);
    }

    #endregion

    #region IsHiddenCloseButton (readonly attached property)

    private static readonly DependencyPropertyKey IsHiddenCloseButtonKey =
        DependencyProperty.RegisterAttachedReadOnly(
            "IsHiddenCloseButton",
            typeof (bool),
            OwnerType,
            new FrameworkPropertyMetadata(false));

    public static readonly DependencyProperty IsHiddenCloseButtonProperty =
        IsHiddenCloseButtonKey.DependencyProperty;

    [AttachedPropertyBrowsableForType(typeof(Window))]
    public static bool GetIsHiddenCloseButton(Window obj) {
        return (bool)obj.GetValue(IsHiddenCloseButtonProperty);
    }

    private static void SetIsHiddenCloseButton(Window obj, bool value) {
        obj.SetValue(IsHiddenCloseButtonKey, value);
    }

    #endregion

}

然后在XAML中，你只需要这样设置:

<Window 
    x:Class="WafClient.Presentation.Views.SampleWindow"
    xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
    xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
    xmlns:u="clr-namespace:WafClient.Presentation.Behaviors"
    ResizeMode="NoResize"
    u:WindowBehavior.HideCloseButton="True">
    ...
</Window>

正如在其他答案中所述，您可以使用WindowStyle="None"来完全删除标题栏。

并且，正如其他答案的评论中所述，这阻止了窗口的可拖动性，因此很难将其从初始位置移动。

但是，你可以通过在窗口的代码后面文件的构造函数中添加一行代码来克服这个问题:

MouseDown += delegate { DragMove(); };

或者，如果你喜欢Lambda语法:

MouseDown += (sender, args) => DragMove();

这使得整个窗口可拖动。窗口中出现的任何交互控件，如按钮，仍将正常工作，不会作为窗口的拖拽句柄。

这就是你的问题所在。窗口框右上方的关闭按钮不是WPF窗口的一部分，但它属于由操作系统控制的窗口框的一部分。这意味着你必须使用Win32互操作来实现。

或者，您可以使用noframe并提供您自己的“框架”或根本没有框架。

在寻找了很多答案之后，我想出了这个简单的解决方法，我将在这里分享，希望它能帮助到其他人。

我设置WindowStyle=0x10000000。

这设置了窗口样式的WS_VISIBLE (0x10000000)和WS_OVERLAPPED (0x0)值。"Overlapped"是显示标题栏和窗口边框的必要值。通过从我的样式值中删除WS_MINIMIZEBOX (0x20000)、WS_MAXIMIZEBOX (0x10000)和WS_SYSMENU (0x80000)值，标题栏中的所有按钮都被删除了，包括关闭按钮。