补充Matt Frear的回答-这将是一个asp.net Core的选择，直接从流读取文件，而不需要保存和从磁盘读取:

public ActionResult OnPostUpload(List<IFormFile> files)
    {
        try
        {
            var file = files.FirstOrDefault();
            var inputstream = file.OpenReadStream();

            XSSFWorkbook workbook = new XSSFWorkbook(stream);

            var FIRST_ROW_NUMBER = {{firstRowWithValue}};

            ISheet sheet = workbook.GetSheetAt(0);
            // Example: var firstCellRow = (int)sheet.GetRow(0).GetCell(0).NumericCellValue;

            for (int rowIdx = 2; rowIdx <= sheet.LastRowNum; rowIdx++)
               {
                  IRow currentRow = sheet.GetRow(rowIdx);

                  if (currentRow == null || currentRow.Cells == null || currentRow.Cells.Count() < FIRST_ROW_NUMBER) break;

                  var df = new DataFormatter();                

                  for (int cellNumber = {{firstCellWithValue}}; cellNumber < {{lastCellWithValue}}; cellNumber++)
                      {
                         //business logic & saving data to DB                        
                      }               
                }
        }
        catch(Exception ex)
        {
            throw new FileFormatException($"Error on file processing - {ex.Message}");
        }
    }

API控制器:

[HttpPost]
public HttpResponseMessage Post()
{
    var httpRequest = System.Web.HttpContext.Current.Request;

    if (System.Web.HttpContext.Current.Request.Files.Count < 1)
    {
        //TODO
    }
    else
    {

    try
    { 
        foreach (string file in httpRequest.Files)
        { 
            var postedFile = httpRequest.Files[file];
            BinaryReader binReader = new BinaryReader(postedFile.InputStream);
            byte[] byteArray = binReader.ReadBytes(postedFile.ContentLength);

        }

    }
    catch (System.Exception e)
    {
        //TODO
    }

    return Request.CreateResponse(HttpStatusCode.Created);
}

下面是一个快速而简单的解决方案，它从HTTP正文中获取上传的文件内容并将其写入文件。我为文件上传包含了一个“骨架”HTML/JS片段。

Web API方法:

[Route("api/myfileupload")]        
[HttpPost]
public string MyFileUpload()
{
    var request = HttpContext.Current.Request;
    var filePath = "C:\\temp\\" + request.Headers["filename"];
    using (var fs = new System.IO.FileStream(filePath, System.IO.FileMode.Create))
    {
        request.InputStream.CopyTo(fs);
    }
    return "uploaded";
}

HTML文件上传:

<form>
    <input type="file" id="myfile"/>  
    <input type="button" onclick="uploadFile();" value="Upload" />
</form>
<script type="text/javascript">
    function uploadFile() {        
        var xhr = new XMLHttpRequest();                 
        var file = document.getElementById('myfile').files[0];
        xhr.open("POST", "api/myfileupload");
        xhr.setRequestHeader("filename", file.name);
        xhr.send(file);
    }
</script>

请参阅http://www.asp.net/web-api/overview/formats-and-model-binding/html-forms-and-multipart-mime#multipartmime，尽管我认为这篇文章让它看起来比实际情况更复杂。

基本上,

public Task<HttpResponseMessage> PostFile() 
{ 
    HttpRequestMessage request = this.Request; 
    if (!request.Content.IsMimeMultipartContent()) 
    { 
        throw new HttpResponseException(HttpStatusCode.UnsupportedMediaType); 
    } 

    string root = System.Web.HttpContext.Current.Server.MapPath("~/App_Data/uploads"); 
    var provider = new MultipartFormDataStreamProvider(root); 

    var task = request.Content.ReadAsMultipartAsync(provider). 
        ContinueWith<HttpResponseMessage>(o => 
    { 

        string file1 = provider.BodyPartFileNames.First().Value;
        // this is the file name on the server where the file was saved 

        return new HttpResponseMessage() 
        { 
            Content = new StringContent("File uploaded.") 
        }; 
    } 
    ); 
    return task; 
} 

在我更新webapi mvc4项目中的所有nuget之前，我使用了Mike Wasson的答案。一旦我这样做了，我必须重写文件上传操作:

    public Task<HttpResponseMessage> Upload(int id)
    {
        HttpRequestMessage request = this.Request;
        if (!request.Content.IsMimeMultipartContent())
        {
            throw new HttpResponseException(new HttpResponseMessage(HttpStatusCode.UnsupportedMediaType));
        }

        string root = System.Web.HttpContext.Current.Server.MapPath("~/App_Data/uploads");
        var provider = new MultipartFormDataStreamProvider(root);

        var task = request.Content.ReadAsMultipartAsync(provider).
            ContinueWith<HttpResponseMessage>(o =>
            {
                FileInfo finfo = new FileInfo(provider.FileData.First().LocalFileName);

                string guid = Guid.NewGuid().ToString();

                File.Move(finfo.FullName, Path.Combine(root, guid + "_" + provider.FileData.First().Headers.ContentDisposition.FileName.Replace("\"", "")));

                return new HttpResponseMessage()
                {
                    Content = new StringContent("File uploaded.")
                };
            }
        );
        return task;
    }

显然BodyPartFileNames在MultipartFormDataStreamProvider中不再可用。

[HttpPost]
public JsonResult PostImage(HttpPostedFileBase file)
{
    try
    {
        if (file != null && file.ContentLength > 0 && file.ContentLength<=10485760)
        {
            var fileName = Path.GetFileName(file.FileName);                                        

            var path = Path.Combine(Server.MapPath("~/") + "HisloImages" + "\\", fileName);

            file.SaveAs(path);
            #region MyRegion
            ////save imag in Db
            //using (MemoryStream ms = new MemoryStream())
            //{
            //    file.InputStream.CopyTo(ms);
            //    byte[] array = ms.GetBuffer();
            //} 
            #endregion
            return Json(JsonResponseFactory.SuccessResponse("Status:0 ,Message: OK"), JsonRequestBehavior.AllowGet);
        }
        else
        {
            return Json(JsonResponseFactory.ErrorResponse("Status:1 , Message: Upload Again and File Size Should be Less Than 10MB"), JsonRequestBehavior.AllowGet);
        }
    }
    catch (Exception ex)
    {

        return Json(JsonResponseFactory.ErrorResponse(ex.Message), JsonRequestBehavior.AllowGet);

    }
}