如果你需要玩游戏的话。正如本文https://www.learncodebygaming.com/blog/pyautogui-not-working-use-directinput中所解释的，像《我的世界》或《堡垒之夜》等游戏都有自己的鼠标/键盘事件注册方式。控制鼠标和键盘事件的方法是使用全新的PyDirectInput库。他们的github知识库是https://github.com/learncodebygaming/pydirectinput，有很多很棒的信息。 下面是一个快速的代码，执行鼠标循环，点击:

import pydirectinput  # pip install pydirectinput


pydirectinput.moveTo(0, 500)
pydirectinput.click()

import ctypes
from time import sleep

SetCursorPos = ctypes.windll.user32.SetCursorPos
print("Woohoo!\nTake Rest!\nMouse pointer will keep moving!\n\nPress ctrl+c to stop...!")
while True:
    SetCursorPos(300, 300)
    sleep(2)
    SetCursorPos(500, 500)
    sleep(4)

尝试使用PyAutoGUI模块。多平台。

pip install pyautogui

所以:

import pyautogui
pyautogui.click(100, 100)

它还有其他特点:

import pyautogui
pyautogui.moveTo(100, 150)
pyautogui.moveRel(0, 10)  # move mouse 10 pixels down
pyautogui.dragTo(100, 150)
pyautogui.dragRel(0, 10)  # drag mouse 10 pixels down

这比浏览win32con的所有东西要容易得多。

快速和肮脏的函数，在Windows 7上使用ctypes库左键点击。无需下载。

import ctypes

SetCursorPos = ctypes.windll.user32.SetCursorPos
mouse_event = ctypes.windll.user32.mouse_event

def left_click(x, y, clicks=1):
  SetCursorPos(x, y)
  for i in xrange(clicks):
   mouse_event(2, 0, 0, 0, 0)
   mouse_event(4, 0, 0, 0, 0)

left_click(200, 200) #left clicks at 200, 200 on your screen. Was able to send 10k clicks instantly.

测试在WinXP, Python 2.6(3。在安装pywin32(在我的情况下是pywin32-214.win32-py2.6.exe)后:

import win32api, win32con
def click(x,y):
    win32api.SetCursorPos((x,y))
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTDOWN,x,y,0,0)
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP,x,y,0,0)
click(10,10)

尝试Clicknium, https://www.clicknium.com/documents/references/python/mouse/ 它可以控制鼠标和键盘，并帮助您定位web浏览器和桌面应用程序中的UI元素。

这是一个沿着圆圈移动鼠标的示例

from time import sleep
import math
from clicknium import clicknium as cc
def circle():
    a,b = cc.mouse.position()
    w = 20  
    m = (2*math.pi)/w 
    r = 200      

    while 1:    
        for i in range(0, w+1):
            x = int(a+r*math.sin(m*i))  
            y = int(b+r*math.cos(m*i))
            cc.mouse.move(x,y)
            sleep(0.2)

if __name__ == "__main__":
    circle()