如果你需要玩游戏的话。正如本文https://www.learncodebygaming.com/blog/pyautogui-not-working-use-directinput中所解释的，像《我的世界》或《堡垒之夜》等游戏都有自己的鼠标/键盘事件注册方式。控制鼠标和键盘事件的方法是使用全新的PyDirectInput库。他们的github知识库是https://github.com/learncodebygaming/pydirectinput，有很多很棒的信息。 下面是一个快速的代码，执行鼠标循环，点击:

import pydirectinput  # pip install pydirectinput


pydirectinput.moveTo(0, 500)
pydirectinput.click()

快速和肮脏的函数，在Windows 7上使用ctypes库左键点击。无需下载。

import ctypes

SetCursorPos = ctypes.windll.user32.SetCursorPos
mouse_event = ctypes.windll.user32.mouse_event

def left_click(x, y, clicks=1):
  SetCursorPos(x, y)
  for i in xrange(clicks):
   mouse_event(2, 0, 0, 0, 0)
   mouse_event(4, 0, 0, 0, 0)

left_click(200, 200) #left clicks at 200, 200 on your screen. Was able to send 10k clicks instantly.

Linux

from Xlib import X, display
d = display.Display()
s = d.screen()
root = s.root
root.warp_pointer(300,300)
d.sync()

来源:Python鼠标移动5行代码(仅适用于Linux)。

Pynput是我发现的最好的解决方案，无论是Windows还是Mac。超级容易编程，工作得非常好。

例如,

from pynput.mouse import Button, Controller

mouse = Controller()

# Read pointer position
print('The current pointer position is {0}'.format(
    mouse.position))

# Set pointer position
mouse.position = (10, 20)
print('Now we have moved it to {0}'.format(
    mouse.position))

# Move pointer relative to current position
mouse.move(5, -5)

# Press and release
mouse.press(Button.left)
mouse.release(Button.left)

# Double click; this is different from pressing and releasing
# twice on Mac OSX
mouse.click(Button.left, 2)

# Scroll two steps down
mouse.scroll(0, 2)

另一种选择是使用跨平台AutoPy包。这个包有两个不同的选项来移动鼠标:

这段代码片段将立即将光标移动到(200,200)位置:

import autopy
autopy.mouse.move(200,200)

如果你想让光标在屏幕上移动到一个给定的位置，你可以使用smooth_move命令:

import autopy
autopy.mouse.smooth_move(200,200)

查看跨平台PyMouse: https://github.com/pepijndevos/PyMouse/