Pynput是我发现的最好的解决方案，无论是Windows还是Mac。超级容易编程，工作得非常好。

例如,

from pynput.mouse import Button, Controller

mouse = Controller()

# Read pointer position
print('The current pointer position is {0}'.format(
    mouse.position))

# Set pointer position
mouse.position = (10, 20)
print('Now we have moved it to {0}'.format(
    mouse.position))

# Move pointer relative to current position
mouse.move(5, -5)

# Press and release
mouse.press(Button.left)
mouse.release(Button.left)

# Double click; this is different from pressing and releasing
# twice on Mac OSX
mouse.click(Button.left, 2)

# Scroll two steps down
mouse.scroll(0, 2)

查看跨平台PyMouse: https://github.com/pepijndevos/PyMouse/

另一种选择是使用跨平台AutoPy包。这个包有两个不同的选项来移动鼠标:

这段代码片段将立即将光标移动到(200,200)位置:

import autopy
autopy.mouse.move(200,200)

如果你想让光标在屏幕上移动到一个给定的位置，你可以使用smooth_move命令:

import autopy
autopy.mouse.smooth_move(200,200)

快速和肮脏的函数，在Windows 7上使用ctypes库左键点击。无需下载。

import ctypes

SetCursorPos = ctypes.windll.user32.SetCursorPos
mouse_event = ctypes.windll.user32.mouse_event

def left_click(x, y, clicks=1):
  SetCursorPos(x, y)
  for i in xrange(clicks):
   mouse_event(2, 0, 0, 0, 0)
   mouse_event(4, 0, 0, 0, 0)

left_click(200, 200) #left clicks at 200, 200 on your screen. Was able to send 10k clicks instantly.

尝试使用pyautogui，简单，也可以模拟键盘上的按键

测试在WinXP, Python 2.6(3。在安装pywin32(在我的情况下是pywin32-214.win32-py2.6.exe)后:

import win32api, win32con
def click(x,y):
    win32api.SetCursorPos((x,y))
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTDOWN,x,y,0,0)
    win32api.mouse_event(win32con.MOUSEEVENTF_LEFTUP,x,y,0,0)
click(10,10)