这里有一些解决方案，人们建议编写精确的布局css类，使用伪元素伪造最后一项，使用非flexbox方法等。

一个大问题是邻居之间的间隙(大小写对齐的按钮包装到多行)。在这种情况下，你不希望物品相互接触，就需要有空隙。我只是想添加一个适当的解决方案，尊重差距，并适用于任何数量的项目。它也是基于假的最后一个元素的想法，但更普遍。有关详细信息，请参阅代码片段注释。

html { font-size: 1px; } .container { font-size: 16rem; display: flex; flex-wrap: wrap; justify-content: space-between; } .item { background-color: orange; border-radius: 10rem; box-sizing: border-box; color: white; margin-bottom: 10rem; padding: 15rem 10rem; text-align: center; } <!-- Our setup from design (example) used later in calculations: container-width: 100%; (can be any) max-per-row = 4; total = 6; desired-hor-gap = 10rem; (equal to vert. gap) If you go dynamic (drawing html according to the coming data either in a backend template or in a frontend template), you have to calculate and then set exact properties inline. <i> (or any real html element) is needed to set inline styles to arrange the last row properly. "2" in <i> calc function - is 6 % 4 since calc doesn't allow for "%" operator. But in real life you will calculate these numbers in JS or some backend template anyway. Formulas written in elements' calc functions. Seem to be self-descriptive, but the idea is to set for the last fake item the remainder width + hypothetical gaps. --> <div class="container"> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <div style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4);" class="item">do stuff</div> <i style="flex: 0 1 calc((100% - (4 - 1) * 10rem) / 4 * (4 - 2) + ( 4 - 2 - 1) * 10rem);"></i> </div>

你不能。Flexbox不是一个网格系统。它没有实现您所要求的功能的语言结构，至少在使用justify-content: space between时是这样。使用Flexbox最接近的方法是使用列方向，这需要设置显式的高度:

http://cssdeck.com/labs/pvsn6t4z(注:不包括前缀)

ul {
  display: flex;
  flex-flow: column wrap;
  align-content: space-between;
  height: 4em;
}

然而，只使用列会更简单，它有更好的支撑，不需要设置特定的高度:

http://cssdeck.com/labs/dwq3x6vr(注:不包括前缀)

ul {
  columns: 15em;
}

我发现了一个有效的解决方案，证明内容也可以居中/空间均匀/等等…(如果你知道单行中的条目数):

HTML:

<section class="container">
    <div class="flex-item"></div>
    <div class="flex-item"></div>
    <div class="flex-item"></div>
    <div class="flex-item"></div>
    <div class="flex-item"></div>

    <p aria-hidden="true"></p>
    <p aria-hidden="true"></p>
    <p aria-hidden="true"></p>
  </section>

<p>标签的数量(它可以是任何其他标签)是每行中的项目数量减1。对于不同的屏幕尺寸，您可以使用媒体查询操作它。

CSS:

.container {
  display: flex;
  flex-wrap: wrap;
  justify-content: center;
  gap: 20px;
}

.flex-item {
  width: 300px;
  height: 300px;
  background: #21BA45;
}

.container > p {
  width: 300px;
  height: 300px;
}

我喜欢@Dan Andreasson和@Robin的简单回答Métral..然而，它并不完全适用于我。

所以不要:

.grid {
display: flex;
flex-flow: row wrap;
justify-content: space-between;
}
.grid::after {
content: "";
flex: auto;
}

我使用:

.grid {
display: flex;
flex-flow: row wrap;
justify-content: space-between;
}
.grid::after {
content: "";
width: calc(100%/3 - 20px); /* whatever width grid items are */
}

到目前为止，这似乎是预期的效果。

这很老套，但对我来说很管用。我试图达到一致的间距/边距。

.grid {
  width: 1024px;
  display: flex;
  flex-flow: row wrap;
  padding: 32px;
  background-color: #ddd;  

  &:after {
    content: "";
    flex: auto;
    margin-left:-1%;
  }

  .item {
    flex: 1 0 24.25%;
    max-width: 24.25%;
    margin-bottom: 10px;
    text-align: center;
    background-color: #bbb;

    &:nth-child(4n+2),
    &:nth-child(4n+3),
    &:nth-child(4n+4) {
      margin-left: 1%;
    }

    &:nth-child(4n+1):nth-last-child(-n+4),
      &:nth-child(4n+1):nth-last-child(-n+4) ~ .item {
        margin-bottom: 0;
    }    

  }
}

http://codepen.io/rustydev/pen/f7c8920e0beb0ba9a904da7ebd9970ae/

没有任何额外的标记，只是添加::after为我指定列的宽度。

.grid {
  display:flex;
  justify-content:space-between;
  flex-wrap:wrap;
}
.grid::after{
  content: '';
  width: 10em // Same width of .grid__element
}
.grid__element{
  width:10em;
}

使用这样的HTML:

<div class=grid">
   <div class="grid__element"></div>
   <div class="grid__element"></div>
   <div class="grid__element"></div>
</div>