对于iOS 9，你需要添加:

if([myTableView respondsToSelector:@selector(setCellLayoutMarginsFollowReadableWidth:)])
{
    myTableView.cellLayoutMarginsFollowReadableWidth = NO;
} 

详情请参阅问题。

迅速:

override func viewDidLoad() {
    super.viewDidLoad()

    if self.tableView.respondsToSelector("setSeparatorInset:") {
        self.tableView.separatorInset = UIEdgeInsetsZero
    }
    if self.tableView.respondsToSelector("setLayoutMargins:") {
        self.tableView.layoutMargins = UIEdgeInsetsZero
    }

    self.tableView.layoutIfNeeded()            // <--- this do the magic
}

override func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell {
     ...

    if cell.respondsToSelector("setSeparatorInset:") {
        cell.separatorInset = UIEdgeInsetsZero
    }
    if cell.respondsToSelector("setLayoutMargins:") {
        cell.layoutMargins = UIEdgeInsetsZero
    }

    return cell
}

XCode 7.1 iOS 7,8,9:

把这两行放到你的TabelViewCell中:

    self.layoutMargins = UIEdgeInsetsZero;
    self.preservesSuperviewLayoutMargins = false;

这对我很有用

Swift 3.0示例:

func tableView(_ tableView: UITableView, willDisplay cell: UITableViewCell, forRowAt indexPath: IndexPath) {
    // removing seperator inset
    if cell.responds(to: #selector(setter: UITableViewCell.separatorInset)) {
        cell.separatorInset = .zero
    }
    // prevent the cell from inheriting the tableView's margin settings
    if cell.responds(to: #selector(setter: UIView.preservesSuperviewLayoutMargins)) {
        cell.preservesSuperviewLayoutMargins = false
    }
    // explicitly setting cell's layout margins
    if cell.responds(to: #selector(setter: UITableViewCell.layoutMargins)) {
        cell.layoutMargins = .zero
    }
}

使用下面的代码片段避免不必要的填充问题UITableView在IOS 8和7。

-(void)tableView:(UITableView *)tableView willDisplayCell:(UITableViewCell *)cell forRowAtIndexPath:(NSIndexPath *)indexPath{

    if ([tableView respondsToSelector:@selector(setSeparatorInset:)])
    {
        [tableView setSeparatorInset:UIEdgeInsetsZero];
    }

    if ([tableView respondsToSelector:@selector(setLayoutMargins:)])
    {
        [tableView setLayoutMargins:UIEdgeInsetsZero];
    }

    if ([cell respondsToSelector:@selector(setLayoutMargins:)])
    {
        [cell setLayoutMargins:UIEdgeInsetsZero];
    }
}

至于cdstamper建议的表格视图，在单元格的layoutSubview方法中添加以下行对我来说是可行的。

- (void)layoutSubviews 
{
    [super layoutSubviews];

    if ([self respondsToSelector:@selector(setSeparatorInset:)])
                [self setSeparatorInset:UIEdgeInsetsZero];

        if ([self respondsToSelector:@selector(setPreservesSuperviewLayoutMargins:)])
        {
            [self setPreservesSuperviewLayoutMargins:NO];;
        }

        if ([self respondsToSelector:@selector(setLayoutMargins:)]) 
        {
            [self setLayoutMargins:UIEdgeInsetsZero];
        }
}