迅速:

override func viewDidLoad() {
    super.viewDidLoad()

    if self.tableView.respondsToSelector("setSeparatorInset:") {
        self.tableView.separatorInset = UIEdgeInsetsZero
    }
    if self.tableView.respondsToSelector("setLayoutMargins:") {
        self.tableView.layoutMargins = UIEdgeInsetsZero
    }

    self.tableView.layoutIfNeeded()            // <--- this do the magic
}

override func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell {
     ...

    if cell.respondsToSelector("setSeparatorInset:") {
        cell.separatorInset = UIEdgeInsetsZero
    }
    if cell.respondsToSelector("setLayoutMargins:") {
        cell.layoutMargins = UIEdgeInsetsZero
    }

    return cell
}

简单地把这两行放在cellForRowAtIndexPath方法中

如果你想要所有的分隔线都从0开始 (细胞setSeparatorInset: UIEdgeInsetsZero); (细胞setLayoutMargins: UIEdgeInsetsZero);

如果你想特定的分隔线是从0开始假设这是最后一行是从0开始

if (indexPath.row == array.count-1) 
{
   [cell setSeparatorInset:UIEdgeInsetsZero];
   [cell setLayoutMargins:UIEdgeInsetsZero];
}
else
   tblView.separatorInset=UIEdgeInsetsMake(0, 10, 0, 0);

你可以使用一次UIAppearance，在你的应用程序启动时(在UI被加载之前)，把它设置为默认的全局设置:

// iOS 7:
[[UITableView appearance] setSeparatorStyle:UITableViewCellSeparatorStyleSingleLine];
[[UITableView appearance] setSeparatorInset:UIEdgeInsetsZero];

[[UITableViewCell appearance] setSeparatorInset:UIEdgeInsetsZero];

// iOS 8:
if ([UITableView instancesRespondToSelector:@selector(setLayoutMargins:)]) {

    [[UITableView appearance] setLayoutMargins:UIEdgeInsetsZero];
    [[UITableViewCell appearance] setLayoutMargins:UIEdgeInsetsZero];
    [[UITableViewCell appearance] setPreservesSuperviewLayoutMargins:NO];

}

这样，你可以保持你的UIViewController的代码干净，如果你想重写它。

iOS 8及更高版本。Swift 2.0及更高版本:

override func tableView(tableView: UITableView, willDisplayCell cell: UITableViewCell, forRowAtIndexPath indexPath: NSIndexPath) {
    cell.separatorInset = UIEdgeInsetsZero
    if #available(iOS 8.0, *) {
        cell.layoutMargins = UIEdgeInsetsZero
    } else {
        // Fallback on earlier versions
    }
}

而不是每次单元格滚动时更新preservessuperviewlayoutmargin和layoutmargin(使用willDisplayCell)，我建议在cellForRowAtIndexPath::

override func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell {

    let cell = super.tableView(tableView, cellForRowAtIndexPath: indexPath)

    cell.preservesSuperviewLayoutMargins = false
    cell.layoutMargins = UIEdgeInsetsZero

    return cell

}

在3楼看到答案后，我试图弄清楚设置TableView和TableViewCell之间的分隔符是什么关系，并做了一些测试。以下是我的结论:

we can consider that setting the cell's separator to zero has to move the separator in two steps: first step is to set cell's separatorinset to zero. second step is to set cell's marginlayout to zero. set the TableView's separatorinset and marginlayout can affect the Cell's separatorinset. However, from the test, I find that the TableView's separatorinset seem to be useless, TableView's marginlayout can actually affect cell's marginlayout. set Cell's PreservesSuperviewLayoutMargins = false, can cut off TableView's marginlayout effect on Cells. one of the solutions: func tableView(tableView: UITableView, cellForRowAtIndexPath indexPath: NSIndexPath) -> UITableViewCell { var cell = UITableViewCell() cell.preservesSuperviewLayoutMargins = false cell.separatorInset = UIEdgeInsetsZero cell.layoutMargins = UIEdgeInsetsZero return cell }