你可以看看TextWriter类。

//Open File
TextWriter tw = new StreamWriter("file.txt");

//Write to file
tw.WriteLine("test info");

//Close File
tw.Close();

我们可以用

public StreamWriter(string path, bool append);

在打开文件时

string path="C:\\MyFolder\\Notes.txt"
StreamWriter writer = new StreamWriter(path, true);

第一个参数是保存完整文件路径的字符串 第二个参数是Append Mode，在本例中为true

写入文件可以通过:

writer.Write(字符串)

or

writer.WriteLine(字符串)

示例代码

private void WriteAndAppend()
{
            string Path = Application.StartupPath + "\\notes.txt";
            FileInfo fi = new FileInfo(Path);
            StreamWriter SW;
            StreamReader SR;
            if (fi.Exists)
            {
                SR = new StreamReader(Path);
                string Line = "";
                while (!SR.EndOfStream) // Till the last line
                {
                    Line = SR.ReadLine();
                }
                SR.Close();
                int x = 0;
                if (Line.Trim().Length <= 0)
                {
                    x = 0;
                }
                else
                {
                    x = Convert.ToInt32(Line.Substring(0, Line.IndexOf('.')));
                }
                x++;
                SW = new StreamWriter(Path, true);
                SW.WriteLine("-----"+string.Format("{0:dd-MMM-yyyy hh:mm:ss tt}", DateTime.Now));
                SW.WriteLine(x.ToString() + "." + textBox1.Text);

            }
            else
            {
                SW = new StreamWriter(Path);
                SW.WriteLine("-----" + string.Format("{0:dd-MMM-yyyy hh:mm:ss tt}", DateTime.Now));
                SW.WriteLine("1." + textBox1.Text);
            }
            SW.Flush();
            SW.Close();
        }

//display sample reg form in notepad.txt
using (StreamWriter stream = new FileInfo("D:\\tt.txt").AppendText())//ur file location//.AppendText())
{
   stream.WriteLine("Name :" + textBox1.Text);//display textbox data in notepad
   stream.WriteLine("DOB : " + dateTimePicker1.Text);//display datepicker data in notepad
   stream.WriteLine("DEP:" + comboBox1.SelectedItem.ToString());
   stream.WriteLine("EXM :" + listBox1.SelectedItem.ToString());
}

技术上最好的方法可能是这样的:

private static async Task AppendLineToFileAsync([NotNull] string path, string line)
{
    if (string.IsNullOrWhiteSpace(path)) 
        throw new ArgumentOutOfRangeException(nameof(path), path, "Was null or whitepsace.");

    if (!File.Exists(path)) 
        throw new FileNotFoundException("File not found.", nameof(path));

    using (var file = File.Open(path, FileMode.Append, FileAccess.Write))
    using (var writer = new StreamWriter(file))
    {
        await writer.WriteLineAsync(line);
        await writer.FlushAsync();
    }
}

您可以使用File。它的AppendAllText:

File.AppendAllText(@"c:\path\file.txt", "text content" + Environment.NewLine);

或者您可以使用File。AppendAllLines(字符串,IEnumerable <字符串>)

File.AppendAllLines(@"C:\Path\file.txt", new[] { "my text content" });